ID   VSR_GVAIS               Reviewed;          90 AA.
AC   Q67708;
DT   02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 2.
DT   07-OCT-2020, entry version 40.
DE   RecName: Full=RNA silencing suppressor;
GN   Name=ORF5;
OS   Grapevine virus A (isolate Is 151) (GVA).
OC   Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes;
OC   Tymovirales; Betaflexiviridae; Trivirinae; Vitivirus.
OX   NCBI_TaxID=651358;
OH   NCBI_TaxID=29760; Vitis vinifera (Grape).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RA   Minafra A.;
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION.
RX   PubMed=16847135; DOI=10.1099/vir.0.81893-0;
RA   Zhou Z.S., Dell'Orco M., Saldarelli P., Turturo C., Minafra A.,
RA   Martelli G.P.;
RT   "Identification of an RNA-silencing suppressor in the genome of Grapevine
RT   virus A.";
RL   J. Gen. Virol. 87:2387-2395(2006).
CC   -!- FUNCTION: Suppressor of viral-induced RNA silencing. The potential
CC       mechanism of action is based on sequestering siRNAs.
CC       {ECO:0000269|PubMed:16847135}.
CC   -!- SIMILARITY: Belongs to the carlaviruses nucleic acid-binding protein
CC       family. {ECO:0000305}.
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DR   EMBL; X75433; CAA53186.2; -; Genomic_RNA.
DR   PIR; S44999; S44999.
DR   RefSeq; NP_619666.2; NC_003604.2.
DR   GeneID; 940185; -.
DR   KEGG; vg:940185; -.
DR   Proteomes; UP000000679; Genome.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR008891; Viral_NABP.
DR   Pfam; PF05515; Viral_NABP; 1.
PE   3: Inferred from homology;
KW   Reference proteome; RNA-binding; Suppressor of RNA silencing.
FT   CHAIN           1..90
FT                   /note="RNA silencing suppressor"
FT                   /id="PRO_0000401093"
FT   REGION          15..18
FT                   /note="Basic"
SQ   SEQUENCE   90 AA;  10528 MW;  6994403FA9ADD452 CRC64;
     MDDPSFLTGR STFAKRRRAR RMNVCKCGAI MHNNKDCKSS SISSHKLDRL RFVKEGRVAL
     TGETPVYRTW VKWVETEYHI YIVETSDDED