ID   VSR_PCV87               Reviewed;         124 AA.
AC   Q84688;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   23-FEB-2022, entry version 43.
DE   RecName: Full=Suppressor of RNA silencing;
DE   AltName: Full=15kD cysteine rich protein;
DE            Short=P15;
GN   ORFNames=ORF2;
OS   Peanut clump virus (isolate 87/TGTA2) (PCV).
OC   Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes;
OC   Martellivirales; Virgaviridae; Pecluvirus.
OX   NCBI_TaxID=652837;
OH   NCBI_TaxID=3818; Arachis hypogaea (Peanut).
OH   NCBI_TaxID=4555; Setaria italica (Foxtail millet) (Panicum italicum).
OH   NCBI_TaxID=91525; Sorghum arundinaceum.
OH   NCBI_TaxID=4558; Sorghum bicolor (Sorghum) (Sorghum vulgare).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=7964624; DOI=10.1099/0022-1317-75-11-3147;
RA   Herzog E., Guilley H., Manohar S.K., Dollet M., Richards K., Fritsch C.,
RA   Jonard G.;
RT   "Complete nucleotide sequence of peanut clump virus RNA 1 and relationships
RT   with other fungus-transmitted rod-shaped viruses.";
RL   J. Gen. Virol. 75:3147-3155(1994).
RN   [2]
RP   RETRACTED PAPER.
RX   PubMed=11874569; DOI=10.1046/j.0960-7412.2001.01242.x;
RA   Dunoyer P., Pfeffer S., Fritsch C., Hemmer O., Voinnet O., Richards K.E.;
RT   "Identification, subcellular localization and some properties of a
RT   cysteine-rich suppressor of gene silencing encoded by peanut clump virus.";
RL   Plant J. 29:555-567(2002).
RN   [3]
RP   RETRACTION NOTICE OF PUBMED:11874569.
RX   PubMed=32202019; DOI=10.1111/tpj.14702;
RA   Dunoyer P., Pfeffer S., Fritsch C., Hemmer O., Voinnet O., Richards K.E.;
RL   Plant J. 101:1249-1249(2020).
CC   -!- FUNCTION: Suppressor of RNA-mediated gene silencing, also known as
CC       post-transcriptional gene silencing (PTGS), a mechanism of plant viral
CC       defense that limits the accumulation of viral RNAs. Promotes viral
CC       cell-to-cell long distance movement. {ECO:0000250|UniProtKB:Q80874}.
CC   -!- SUBUNIT: Homooligomer. {ECO:0000250|UniProtKB:Q80874}.
CC   -!- SUBCELLULAR LOCATION: Host chloroplast envelope
CC       {ECO:0000250|UniProtKB:Q80874}. Host endoplasmic reticulum
CC       {ECO:0000250|UniProtKB:Q80874}. Host cell junction, host plasmodesma
CC       {ECO:0000250|UniProtKB:Q80874}.
CC   -!- DOMAIN: The domains BM and C2 are involved in zinc-binding. Zinc-
CC       binding of each of the motifs is critical for the biological activity.
CC       {ECO:0000250|UniProtKB:Q80874}.
CC   -!- DOMAIN: The coiled coil domain is probably involved in
CC       homooligomerization. {ECO:0000250|UniProtKB:Q80874}.
CC   -!- PTM: Phosphorylated at Ser-79 by a host PKA-like kinase; the
CC       phosphorylation at this site seems to suppress host cell death.
CC       {ECO:0000250|UniProtKB:Q80874}.
CC   -!- SIMILARITY: Belongs to the virgaviridae suppressor of RNA silencing
CC       family. {ECO:0000305}.
CC   -!- CAUTION: The publication has been retracted because some figures
CC       presented signs of inappropriate manipulation.
CC       {ECO:0000305|PubMed:32202019}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X78602; CAA55336.1; -; Genomic_RNA.
DR   RefSeq; NP_620041.1; NC_003672.1.
DR   SMR; Q84688; -.
DR   GeneID; 991044; -.
DR   KEGG; vg:991044; -.
DR   Proteomes; UP000001668; Genome.
DR   GO; GO:0044165; C:host cell endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0044219; C:host cell plasmodesma; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR007609; Viral_P18.
DR   Pfam; PF04521; Viral_P18; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Host cell junction; Host endoplasmic reticulum; Metal-binding;
KW   Phosphoprotein; Reference proteome; Suppressor of RNA silencing; Zinc.
FT   CHAIN           1..124
FT                   /note="Suppressor of RNA silencing"
FT                   /id="PRO_0000409148"
FT   REGION          1..14
FT                   /note="Basic motif (BM)"
FT   REGION          30..68
FT                   /note="C-2"
FT                   /evidence="ECO:0000250|UniProtKB:Q80874"
FT   COILED          72..124
FT                   /evidence="ECO:0000255"
FT   MOD_RES         79
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q80874"
SQ   SEQUENCE   124 AA;  14573 MW;  45E9761A9A744A14 CRC64;
     MPKSEFFREE RKRRVALLGE DAVCKLNGVC GYSCGMPPAV EKVSVPADTE EDVYMLIFPY
     EQFCGEKHFK LYESLKDVSD DELKLRRLER QRETLLASFQ QKLKRYDEKI ALLSEKFKNL
     RSKL