ID   VSR_PMTVS               Reviewed;          68 AA.
AC   Q779L9;
DT   14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   23-FEB-2022, entry version 16.
DE   RecName: Full=Suppressor of RNA silencing;
DE   AltName: Full=8kD cysteine rich protein;
DE            Short=P8;
GN   Name=8K protein;
OS   Potato mop-top virus (isolate Potato/Sweden/Sw) (PMTV).
OC   Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes;
OC   Martellivirales; Virgaviridae; Pomovirus.
OX   NCBI_TaxID=652839;
OH   NCBI_TaxID=4112; Solanum nigrum (Black nightshade).
OH   NCBI_TaxID=4113; Solanum tuberosum (Potato).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RA   Savenkov E.I., Sandgren M., Germundsson A.;
RT   "Complete sequence of RNA2 from Potato mop-top virus (PMTV-Sw).";
RL   Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=16186244; DOI=10.1099/vir.0.81099-0;
RA   Lukhovitskaya N.I., Yelina N.E., Zamyatnin A.A. Jr., Schepetilnikov M.V.,
RA   Solovyev A.G., Sandgren M., Morozov S.Y., Valkonen J.P., Savenkov E.I.;
RT   "Expression, localization and effects on virulence of the cysteine-rich 8
RT   kDa protein of Potato mop-top virus.";
RL   J. Gen. Virol. 86:2879-2889(2005).
RN   [3]
RP   FUNCTION.
RX   PubMed=31299487; DOI=10.1016/j.virol.2019.06.018;
RA   Kalyandurg P.B., Tahmasebi A., Vetukuri R.R., Kushwaha S.K., Lezzhov A.A.,
RA   Solovyev A.G., Grenville-Briggs L.J., Savenkov E.I.;
RT   "Efficient RNA silencing suppression activity of Potato Mop-Top Virus 8K
RT   protein is driven by variability and positive selection.";
RL   Virology 535:111-121(2019).
CC   -!- FUNCTION: Suppressor of RNA-mediated gene silencing, also known as
CC       post-transcriptional gene silencing (PTGS), a mechanism of plant viral
CC       defense that performs sequence-specific inhibition of viral mRNAs
CC       expression (PubMed:16186244, PubMed:31299487). The RNA silencing
CC       suppression activity is variable depending on the origin of the isolate
CC       (PubMed:31299487). {ECO:0000269|PubMed:16186244,
CC       ECO:0000269|PubMed:31299487}.
CC   -!- SUBCELLULAR LOCATION: Host endoplasmic reticulum membrane
CC       {ECO:0000269|PubMed:16186244}; Single-pass membrane protein
CC       {ECO:0000269|PubMed:16186244}. Note=Localizes to host ER-derived
CC       membranes. {ECO:0000269|PubMed:16186244}.
CC   -!- SIMILARITY: Belongs to the virgaviridae suppressor of RNA silencing
CC       family. {ECO:0000305}.
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DR   EMBL; AJ277556; CAB91104.1; -; Genomic_RNA.
DR   RefSeq; NP_620441.1; NC_003725.1.
DR   GeneID; 991173; -.
DR   KEGG; vg:991173; -.
DR   Proteomes; UP000006715; Genome.
DR   GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Host endoplasmic reticulum; Host membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..68
FT                   /note="Suppressor of RNA silencing"
FT                   /id="PRO_0000414119"
FT   TRANSMEM        23..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   68 AA;  7970 MW;  27DF4690ECB4DFB5 CRC64;
     MERRFIVYYN CSDCACGRYV SSLLTMSGAY VNVCVCIVFF ILVYLSSCYN MRVLGFLRVC
     IYLYKLCR