ID   VSR_PVMG                Reviewed;         108 AA.
AC   Q01687;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   23-FEB-2022, entry version 52.
DE   RecName: Full=RNA silencing suppressor;
DE   AltName: Full=12 kDa protein;
DE   AltName: Full=Cysteine-rich protein;
DE            Short=CRP;
DE   AltName: Full=Nucleic acid-binding regulatory protein;
DE   AltName: Full=PR12;
OS   Potato virus M (strain German) (PVM).
OC   Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes;
OC   Tymovirales; Betaflexiviridae; Quinvirinae; Carlavirus.
OX   NCBI_TaxID=31710;
OH   NCBI_TaxID=4113; Solanum tuberosum (Potato).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=2265707; DOI=10.1016/0014-5793(90)80500-i;
RA   Gramstat A., Courtpozanis A., Rohde W.;
RT   "The 12 kDa protein of potato virus M displays properties of a nucleic
RT   acid-binding regulatory protein.";
RL   FEBS Lett. 276:34-38(1990).
RN   [2]
RP   FUNCTION.
RX   PubMed=21752911; DOI=10.1128/jvi.05273-11;
RA   Senshu H., Yamaji Y., Minato N., Shiraishi T., Maejima K., Hashimoto M.,
RA   Miura C., Neriya Y., Namba S.;
RT   "A dual strategy for the suppression of host antiviral silencing: two
RT   distinct suppressors for viral replication and viral movement encoded by
RT   potato virus M.";
RL   J. Virol. 85:10269-10278(2011).
CC   -!- FUNCTION: Suppressor of viral-induced RNA silencing. The potential
CC       mechanism of action is based on sequestering siRNAs.
CC       {ECO:0000269|PubMed:21752911}.
CC   -!- SIMILARITY: Belongs to the carlaviruses nucleic acid-binding protein
CC       family. {ECO:0000305}.
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DR   EMBL; X57440; CAA40689.1; -; Genomic_RNA.
DR   PIR; S12976; S12976.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR002568; Carla-bd.
DR   Pfam; PF01623; Carla_C4; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Suppressor of RNA silencing; Zinc; Zinc-finger.
FT   CHAIN           1..108
FT                   /note="RNA silencing suppressor"
FT                   /id="PRO_0000222656"
FT   ZN_FING         57..78
FT                   /note="C4-type"
FT                   /evidence="ECO:0000255"
FT   REGION          47..50
FT                   /note="Basic"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   108 AA;  12119 MW;  86E80F8DC0B376E8 CRC64;
     MKDVTKVALL IARAMCTSSG TFVFELAFSI AECAGRPLGG GRSKYARRRR AISIARCHRC
     YRLWPPTVFT TRCDNKYCVP GISYNVRVAQ FIDEGVTEVI PSVINKRE