ID   VSR_PVMR                Reviewed;         108 AA.
AC   P17530;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 2.
DT   23-FEB-2022, entry version 73.
DE   RecName: Full=RNA silencing suppressor;
DE   AltName: Full=10.7 kDa protein;
DE   AltName: Full=Putative nucleic acid-binding protein;
OS   Potato virus M (strain Russian) (PVM).
OC   Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes;
OC   Tymovirales; Betaflexiviridae; Quinvirinae; Carlavirus.
OX   NCBI_TaxID=12168;
OH   NCBI_TaxID=4113; Solanum tuberosum (Potato).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=2738581; DOI=10.1099/0022-1317-70-7-1861;
RA   Rupasov V.V., Morozov S.Y., Kanyuka K.V., Zavriev S.K.;
RT   "Partial nucleotide sequence of potato virus M RNA shows similarities to
RT   protexviruses in gene arrangement and the encoded amino acid sequences.";
RL   J. Gen. Virol. 70:1861-1869(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=1990070; DOI=10.1099/0022-1317-72-1-9;
RA   Zavriev S.K., Kanyuka K.V., Levay K.E.;
RT   "The genome organization of potato virus M RNA.";
RL   J. Gen. Virol. 72:9-14(1991).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=1944258;
RA   Zavriev S.K., Kaniuka K.V., Levai K.E.;
RT   "Complete nucleotide sequence of genomic RNA of the potato M-virus.";
RL   Mol. Biol. (Mosk.) 25:761-769(1991).
RN   [4]
RP   FUNCTION.
RX   PubMed=21752911; DOI=10.1128/jvi.05273-11;
RA   Senshu H., Yamaji Y., Minato N., Shiraishi T., Maejima K., Hashimoto M.,
RA   Miura C., Neriya Y., Namba S.;
RT   "A dual strategy for the suppression of host antiviral silencing: two
RT   distinct suppressors for viral replication and viral movement encoded by
RT   potato virus M.";
RL   J. Virol. 85:10269-10278(2011).
CC   -!- FUNCTION: Suppressor of viral-induced RNA silencing. Increases the
CC       accumulation of viral RNA and enhances viral cell-to-cell movement by
CC       inhibiting RNA silencing. {ECO:0000269|PubMed:21752911}.
CC   -!- SIMILARITY: Belongs to the carlaviruses nucleic acid-binding protein
CC       family. {ECO:0000305}.
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DR   EMBL; D14449; BAA03344.1; -; Genomic_RNA.
DR   PIR; F54333; WMVYP5.
DR   RefSeq; NP_056772.1; NC_001361.2.
DR   PRIDE; P17530; -.
DR   GeneID; 1493994; -.
DR   KEGG; vg:1493994; -.
DR   Proteomes; UP000000677; Genome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR002568; Carla-bd.
DR   Pfam; PF01623; Carla_C4; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Reference proteome;
KW   Suppressor of RNA silencing; Zinc; Zinc-finger.
FT   CHAIN           1..108
FT                   /note="RNA silencing suppressor"
FT                   /id="PRO_0000222657"
FT   ZN_FING         57..78
FT                   /note="C4-type"
FT                   /evidence="ECO:0000255"
FT   REGION          47..50
FT                   /note="Basic"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        80..107
FT                   /note="PGISYNVRVAQFIDEGVTEVIPSVINKR -> LVSLTMCAWRNLLMK (in
FT                   Ref. 1)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   108 AA;  12183 MW;  00886E246A553B53 CRC64;
     MKDVTKVALL IARAMCASSG TFVFELAFSI TEYTGRPLGG GRSKYARRRR AISIARCHRC
     YRLWPPTVFT TRCDNKHCVP GISYNVRVAQ FIDEGVTEVI PSVINKRE