ID   VSR_RHBVC               Reviewed;         203 AA.
AC   Q67897;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   02-JUN-2021, entry version 53.
DE   RecName: Full=Suppressor of RNA silencing p3;
DE   AltName: Full=Protein NS3;
DE   AltName: Full=Protein p3;
GN   ORFNames=p3;
OS   Rice hoja blanca virus (strain cr) (RHBV) (Rice hoja blanca virus (strain
OS   Costa Rica)).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC   Ellioviricetes; Bunyavirales; Phenuiviridae; Tenuivirus.
OX   NCBI_TaxID=480611;
OH   NCBI_TaxID=4530; Oryza sativa (Rice).
OH   NCBI_TaxID=52841; Oryza sp..
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=8046420; DOI=10.1099/0022-1317-75-8-2127;
RA   de Miranda J., Hernandez M., Hull R., Espinoza A.M.;
RT   "Sequence analysis of rice hoja blanca virus RNA 3.";
RL   J. Gen. Virol. 75:2127-2132(1994).
RN   [2]
RP   FUNCTION.
RX   PubMed=12502849; DOI=10.1128/jvi.77.2.1329-1336.2003;
RA   Bucher E., Sijen T., De Haan P., Goldbach R., Prins M.;
RT   "Negative-strand tospoviruses and tenuiviruses carry a gene for a
RT   suppressor of gene silencing at analogous genomic positions.";
RL   J. Virol. 77:1329-1336(2003).
CC   -!- FUNCTION: Acts as a suppressor of RNA-mediated gene silencing, also
CC       known as post-transcriptional gene silencing (PTGS), presumably through
CC       the binding of dsRNA. {ECO:0000250, ECO:0000269|PubMed:12502849}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the tenuiviruses p3 protein family.
CC       {ECO:0000305}.
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DR   EMBL; L07940; AAA53423.1; -; Genomic_RNA.
DR   PDB; 3AJF; X-ray; 2.00 A; A/B/C/D=21-114.
DR   PDBsum; 3AJF; -.
DR   SMR; Q67897; -.
DR   BRENDA; 3.6.4.13; 17130.
DR   EvolutionaryTrace; Q67897; -.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1440.190; -; 1.
DR   InterPro; IPR007974; Tenui_movmnt_prot.
DR   InterPro; IPR043105; Tenui_NS3.
DR   Pfam; PF05310; Tenui_NS3; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Host cytoplasm; RNA-binding; Suppressor of RNA silencing.
FT   CHAIN           1..203
FT                   /note="Suppressor of RNA silencing p3"
FT                   /id="PRO_0000312157"
FT   TURN            23..25
FT                   /evidence="ECO:0007829|PDB:3AJF"
FT   HELIX           37..50
FT                   /evidence="ECO:0007829|PDB:3AJF"
FT   HELIX           56..64
FT                   /evidence="ECO:0007829|PDB:3AJF"
FT   HELIX           69..84
FT                   /evidence="ECO:0007829|PDB:3AJF"
FT   HELIX           91..93
FT                   /evidence="ECO:0007829|PDB:3AJF"
FT   HELIX           94..105
FT                   /evidence="ECO:0007829|PDB:3AJF"
FT   HELIX           106..109
FT                   /evidence="ECO:0007829|PDB:3AJF"
SQ   SEQUENCE   203 AA;  23204 MW;  66F4B2D33C60ECE4 CRC64;
     MNVSLYYSGT PVSSHSLLSK NGLSNIVLTC KDLPIPIDLL SLFFDILNER HPSFDEHMFL
     QMIRKPDDPE NLSVFLKSAI WMLSHKRDLP GHYRLPLTCL VSTYSEYFVE LKPRQPSTKC
     WFCKIAKDGL PFRVEGVHGF PSEAELYIVP SKEHAIESFE VLSGKKLYRS PSKKKHGYLI
     ASNKPPLTSK YVEYDPSKPD TKP