ID   VSSGP_EBOSU             Reviewed;         319 AA.
AC   P0C772;
DT   09-FEB-2010, integrated into UniProtKB/Swiss-Prot.
DT   09-FEB-2010, sequence version 1.
DT   03-AUG-2022, entry version 32.
DE   RecName: Full=Super small secreted glycoprotein;
DE            Short=SsGP;
DE   Flags: Precursor;
GN   Name=GP;
OS   Sudan ebolavirus (strain Human/Uganda/Gulu/2000) (SEBOV) (Sudan Ebola
OS   virus).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Filoviridae; Ebolavirus.
OX   NCBI_TaxID=386033;
OH   NCBI_TaxID=77231; Epomops franqueti (Franquet's epauleted fruit bat).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=77243; Myonycteris torquata (Little collared fruit bat).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=15367603; DOI=10.1128/jvi.78.19.10370-10377.2004;
RA   Sanchez A., Lukwiya M., Bausch D., Mahanty S., Sanchez A.J., Wagoner K.D.,
RA   Rollin P.E.;
RT   "Analysis of human peripheral blood samples from fatal and nonfatal cases
RT   of Ebola (Sudan) hemorrhagic fever: cellular responses, virus load, and
RT   nitric oxide levels.";
RL   J. Virol. 78:10370-10377(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=15047846; DOI=10.1128/jvi.78.8.4330-4341.2004;
RA   Towner J.S., Rollin P.E., Bausch D.G., Sanchez A., Crary S.M., Vincent M.,
RA   Lee W.F., Spiropoulou C.F., Ksiazek T.G., Lukwiya M., Kaducu F.,
RA   Downing R., Nichol S.T.;
RT   "Rapid diagnosis of Ebola hemorrhagic fever by reverse transcription-PCR in
RT   an outbreak setting and assessment of patient viral load as a predictor of
RT   outcome.";
RL   J. Virol. 78:4330-4341(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=16139097; DOI=10.1016/j.virusres.2005.03.028;
RA   Sanchez A., Rollin P.E.;
RT   "Complete genome sequence of an Ebola virus (Sudan species) responsible for
RT   a 2000 outbreak of human disease in Uganda.";
RL   Virus Res. 113:16-25(2005).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- RNA EDITING: Modified_positions=295; Note=Partially edited. RNA editing
CC       at this position consists of an insertion of one or two adenine
CC       nucleotides. The sequence displayed here is the super small secreted
CC       glycoprotein ssGP, derived from the +2A edited RNA. The unedited RNA
CC       gives rise to the small secreted glycoprotein sGP (AC Q7T9E0), the +1A
CC       edited RNA gives rise to the full-length transmembrane glycoprotein GP
CC       (AC Q7T9D9).;
CC   -!- SIMILARITY: Belongs to the filoviruses glycoprotein family.
CC       {ECO:0000305}.
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DR   EMBL; AY316199; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR   EMBL; AY344234; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR   EMBL; AY729654; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR   SMR; P0C772; -.
DR   Proteomes; UP000000277; Genome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR002561; GPC_filovir-type_extra_dom.
DR   Pfam; PF01611; Filo_glycop; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Glycoprotein; RNA editing; Secreted; Signal.
FT   SIGNAL          1..32
FT                   /evidence="ECO:0000255"
FT   CHAIN           33..319
FT                   /note="Super small secreted glycoprotein"
FT                   /id="PRO_0000391496"
FT   CARBOHYD        40
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        204
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        208
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        238
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        257
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        268
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   DISULFID        53
FT                   /note="Interchain"
FT                   /evidence="ECO:0000250"
FT   DISULFID        108..135
FT                   /evidence="ECO:0000250"
FT   DISULFID        121..147
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   319 AA;  36274 MW;  05B814143DFEC827 CRC64;
     MGGLSLLQLP RDKFRKSSFF VWVIILFQKA FSMPLGVVTN STLEVTEIDQ LVCKDHLAST
     DQLKSVGLNL EGSGVSTDIP SATKRWGFRS GVPPKVVSYE AGEWAENCYN LEIKKPDGSE
     CLPPPPDGVR GFPRCRYVHK AQGTGPCPGD YAFHKDGAFF LYDRLASTVI YRGVNFAEGV
     IAFLILAKPK ETFLQSPPIR EAVNYTENTS SYYATSYLEY EIENFGAQHS TTLFKIDNNT
     FVRLDRPHTP QFLFQLNDTI HLHQQLSNTT GRLIWTLDAN INADIGEWAF WENKKKSLRT
     TTWRRAVFRS FIAQRDRRR