VSSGP_EBOZM
ID VSSGP_EBOZM Reviewed; 298 AA.
AC Q9YMG2;
DT 09-FEB-2010, integrated into UniProtKB/Swiss-Prot.
DT 09-FEB-2010, sequence version 2.
DT 02-JUN-2021, entry version 56.
DE RecName: Full=Super small secreted glycoprotein;
DE Short=SsGP;
DE Flags: Precursor;
GN Name=GP;
OS Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus).
OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC Monjiviricetes; Mononegavirales; Filoviridae; Ebolavirus.
OX NCBI_TaxID=128952;
OH NCBI_TaxID=77231; Epomops franqueti (Franquet's epauleted fruit bat).
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=77243; Myonycteris torquata (Little collared fruit bat).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Mayinga;
RX PubMed=9576958; DOI=10.1073/pnas.95.10.5762;
RA Volchkov V.E., Feldmann H., Volchkova V.A., Klenk H.-D.;
RT "Processing of the Ebola virus glycoprotein by the proprotein convertase
RT furin.";
RL Proc. Natl. Acad. Sci. U.S.A. 95:5762-5767(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Mayinga;
RX PubMed=8482365; DOI=10.1016/0014-5793(93)81107-b;
RA Bukreyev A.A., Volchkov V.E., Blinov V.M., Netesov S.V.;
RT "The VP35 and VP40 proteins of filoviruses. Homology between Marburg and
RT Ebola viruses.";
RL FEBS Lett. 322:41-46(1993).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Mayinga;
RX PubMed=8553543; DOI=10.1006/viro.1995.0052;
RA Volchkov V.E., Becker S., Volchkova V.A., Ternovoj V.A., Kotov A.N.,
RA Netesov S.V., Klenk H.-D.;
RT "GP mRNA of Ebola virus is edited by the Ebola virus polymerase and by T7
RT and vaccinia virus polymerases.";
RL Virology 214:421-430(1995).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Mayinga;
RX PubMed=9614872; DOI=10.1006/viro.1998.9143;
RA Volchkov V.E., Volchkova V.A., Slenczka W., Klenk H.-D., Feldmann H.;
RT "Release of viral glycoproteins during Ebola virus infection.";
RL Virology 245:110-119(1998).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Mayinga;
RX PubMed=10073695; DOI=10.1099/0022-1317-80-2-355;
RA Volchkov V.E., Volchkova V.A., Chepurnov A.A., Blinov V.M., Netesov S.V.,
RA Feldmann H.;
RT "Characterization of the L gene and 5' trailer region of Ebola virus.";
RL J. Gen. Virol. 80:355-362(1999).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Mayinga;
RA Volchkov V.E.;
RL Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Mayinga;
RA Subbotina E.L., Kachko A.V., Dadaeva A.A., Chepurnov A.A.;
RT "Experimental study of molecular determinants of Ebola virus virulence in
RT guinea pigs.";
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- RNA EDITING: Modified_positions=295; Note=Partially edited. RNA editing
CC at this position consists of an insertion of one or two adenine
CC nucleotides. The sequence displayed here is the super small secreted
CC glycoprotein ssGP, derived from the +2A edited RNA. The unedited RNA
CC gives rise to the small secreted glycoprotein sGP (AC P60170), the +1A
CC edited RNA gives rise to the full-length transmembrane glycoprotein GP
CC (AC Q05320).;
CC -!- SIMILARITY: Belongs to the filoviruses glycoprotein family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD14586.1; Type=Erroneous translation; Note=A lysine is missing at the editing site.; Evidence={ECO:0000305};
CC Sequence=ABX75369.1; Type=Erroneous translation; Note=A lysine is missing at the editing site.; Evidence={ECO:0000305};
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DR EMBL; AF086833; AAD14586.1; ALT_SEQ; Genomic_RNA.
DR EMBL; EU224440; ABX75369.1; ALT_SEQ; Viral_cRNA.
DR RefSeq; NP_066248.1; NC_002549.1.
DR SMR; Q9YMG2; -.
DR DNASU; 911829; -.
DR GeneID; 911829; -.
DR Proteomes; UP000007209; Genome.
DR Proteomes; UP000116327; Genome.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR002561; GPC_filovir-type_extra_dom.
DR Pfam; PF01611; Filo_glycop; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Glycoprotein; Reference proteome; RNA editing; Secreted;
KW Signal.
FT SIGNAL 1..32
FT /evidence="ECO:0000255"
FT CHAIN 33..298
FT /note="Super small secreted glycoprotein"
FT /id="PRO_0000391494"
FT CARBOHYD 40
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 204
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 228
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 238
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 257
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 268
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT DISULFID 53
FT /note="Interchain"
FT /evidence="ECO:0000250"
FT DISULFID 108..135
FT /evidence="ECO:0000250"
FT DISULFID 121..147
FT /evidence="ECO:0000250"
SQ SEQUENCE 298 AA; 33520 MW; 584B65414512A61E CRC64;
MGVTGILQLP RDRFKRTSFF LWVIILFQRT FSIPLGVIHN STLQVSDVDK LVCRDKLSST
NQLRSVGLNL EGNGVATDVP SATKRWGFRS GVPPKVVNYE AGEWAENCYN LEIKKPDGSE
CLPAAPDGIR GFPRCRYVHK VSGTGPCAGD FAFHKEGAFF LYDRLASTVI YRGTTFAEGV
VAFLILPQAK KDFFSSHPLR EPVNATEDPS SGYYSTTIRY QATGFGTNET EYLFEVDNLT
YVQLESRFTP QFLLQLNETI YTSGKRSNTT GKLIWKVNPE IDTTIGEWAF WETKKKPH
