VSTM5_HUMAN
ID VSTM5_HUMAN Reviewed; 200 AA.
AC A8MXK1;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=V-set and transmembrane domain-containing protein 5;
DE Flags: Precursor;
GN Name=VSTM5; Synonyms=C11orf90;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Cell adhesion-like membrane protein of the central nervous
CC system (CNS) which modulates both the position and complexity of
CC central neurons by altering their membrane morphology and dynamics.
CC Involved in the formation of neuronal dendrites and protrusions
CC including dendritic filopodia. In synaptogenesis, regulates synapse
CC formation by altering dendritic spine morphology and actin
CC distribution. Promotes formation of unstable neuronal spines such as
CC thin and branched types. Regulates neuronal morphogenesis and migration
CC during cortical development in the brain.
CC {ECO:0000250|UniProtKB:Q9D806}.
CC -!- SUBUNIT: Can homooligomerize through cis interactions within the same
CC cell membrane. {ECO:0000250|UniProtKB:Q9D806}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9D806};
CC Single-pass type I membrane protein {ECO:0000305}. Cell projection,
CC dendrite {ECO:0000250|UniProtKB:Q9D806}. Cell projection, axon
CC {ECO:0000250|UniProtKB:Q9D806}.
CC -!- PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q9D806}.
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DR EMBL; AP001894; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471065; EAW66922.1; -; Genomic_DNA.
DR CCDS; CCDS44709.1; -.
DR RefSeq; NP_001138343.1; NM_001144871.1.
DR AlphaFoldDB; A8MXK1; -.
DR STRING; 9606.ENSP00000386607; -.
DR GlyGen; A8MXK1; 1 site.
DR iPTMnet; A8MXK1; -.
DR PhosphoSitePlus; A8MXK1; -.
DR BioMuta; VSTM5; -.
DR PaxDb; A8MXK1; -.
DR PRIDE; A8MXK1; -.
DR Antibodypedia; 31599; 22 antibodies from 11 providers.
DR DNASU; 387804; -.
DR Ensembl; ENST00000409977.2; ENSP00000386607.1; ENSG00000214376.6.
DR GeneID; 387804; -.
DR KEGG; hsa:387804; -.
DR MANE-Select; ENST00000409977.2; ENSP00000386607.1; NM_001144871.2; NP_001138343.1.
DR UCSC; uc010ruc.2; human.
DR CTD; 387804; -.
DR DisGeNET; 387804; -.
DR GeneCards; VSTM5; -.
DR HGNC; HGNC:34443; VSTM5.
DR HPA; ENSG00000214376; Tissue enhanced (brain, placenta).
DR neXtProt; NX_A8MXK1; -.
DR OpenTargets; ENSG00000214376; -.
DR PharmGKB; PA164716741; -.
DR VEuPathDB; HostDB:ENSG00000214376; -.
DR eggNOG; ENOG502S0GW; Eukaryota.
DR GeneTree; ENSGT00960000186634; -.
DR HOGENOM; CLU_118644_0_0_1; -.
DR InParanoid; A8MXK1; -.
DR OMA; CNRCAYK; -.
DR OrthoDB; 1260992at2759; -.
DR PhylomeDB; A8MXK1; -.
DR TreeFam; TF332950; -.
DR PathwayCommons; A8MXK1; -.
DR SignaLink; A8MXK1; -.
DR BioGRID-ORCS; 387804; 18 hits in 1061 CRISPR screens.
DR GenomeRNAi; 387804; -.
DR Pharos; A8MXK1; Tdark.
DR PRO; PR:A8MXK1; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; A8MXK1; protein.
DR Bgee; ENSG00000214376; Expressed in placenta and 94 other tissues.
DR ExpressionAtlas; A8MXK1; baseline and differential.
DR GO; GO:0030424; C:axon; ISS:UniProtKB.
DR GO; GO:0030425; C:dendrite; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0046847; P:filopodium assembly; ISS:UniProtKB.
DR GO; GO:1904891; P:positive regulation of excitatory synapse assembly; ISS:UniProtKB.
DR GO; GO:0051260; P:protein homooligomerization; ISS:UniProtKB.
DR GO; GO:0021517; P:ventral spinal cord development; IEA:Ensembl.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR SMART; SM00409; IG; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
PE 3: Inferred from homology;
KW Cell membrane; Cell projection; Developmental protein; Glycoprotein;
KW Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..28
FT /evidence="ECO:0000255"
FT CHAIN 29..200
FT /note="V-set and transmembrane domain-containing protein 5"
FT /id="PRO_0000340693"
FT TOPO_DOM 29..147
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 169..200
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 37..139
FT /note="Ig-like C2-type"
FT REGION 170..186
FT /note="Important for CDC42-dependent filopodia induction"
FT /evidence="ECO:0000250|UniProtKB:Q9D806"
FT CARBOHYD 102
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 200 AA; 22377 MW; 8B9EAF98C276CC89 CRC64;
MRPLPSGRRK TRGISLGLFA LCLAAARCLQ SQGVSLYIPQ ATINATVKED ILLSVEYSCH
GVPTIEWTYS SNWGTQKIVE WKPGTQANIS QSHKDRVCTF DNGSIQLFSV GVRDSGYYVI
TVTERLGSSQ FGTIVLHVSE ILYEDLHFVA VILAFLAAVA AVLISLMWVC NKCAYKFQRK
RRHKLKESTT EEIELEDVEC
