ID   VSTX2_GRARO             Reviewed;          32 AA.
AC   P0C2P4;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=Kappa-theraphotoxin-Gr2b;
DE            Short=Kappa-TRTX-Gr2b;
DE   AltName: Full=Voltage sensor toxin 2;
DE            Short=VSTX2;
OS   Grammostola rosea (Chilean rose tarantula) (Grammostola spatulata).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Mygalomorphae; Theraphosidae; Grammostola.
OX   NCBI_TaxID=432528;
RN   [1]
RP   PROTEIN SEQUENCE, AND FUNCTION.
RC   TISSUE=Venom;
RX   PubMed=15287735; DOI=10.1021/bi049463y;
RA   Ruta V., MacKinnon R.;
RT   "Localization of the voltage-sensor toxin receptor on KvAP.";
RL   Biochemistry 43:10071-10079(2004).
CC   -!- FUNCTION: Binds the voltage-sensor domain of the potassium channel KvAP
CC       (from the archaeon Aeropyrum pernix) and affects channel gating.
CC       {ECO:0000269|PubMed:15287735}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the neurotoxin 30 (phrixotoxin) family.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; P0C2P4; -.
DR   SMR; P0C2P4; -.
DR   ArachnoServer; AS000424; kappa-theraphotoxin-Gr2b.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Ion channel impairing toxin;
KW   Knottin; Neurotoxin; Potassium channel impairing toxin; Secreted; Toxin.
FT   PEPTIDE         1..32
FT                   /note="Kappa-theraphotoxin-Gr2b"
FT                   /id="PRO_0000283770"
FT   DISULFID        2..16
FT                   /evidence="ECO:0000250"
FT   DISULFID        9..21
FT                   /evidence="ECO:0000250"
FT   DISULFID        15..25
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   32 AA;  3986 MW;  7CE763EB84DE1AAC CRC64;
     YCQKWMWTCD EERKCCEGLV CRLWCKKKIE EG