ID   VSWB_TRYBR              Reviewed;         487 AA.
AC   P20947;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Variant surface glycoprotein WRATAT B;
DE            Short=VSG;
DE   Flags: Precursor;
OS   Trypanosoma brucei rhodesiense.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=31286;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=WRATat 1;
RX   PubMed=2357229; DOI=10.1016/0006-291x(90)90392-z;
RA   Reddy L.V., Hall T., Donelson J.E.;
RT   "Sequences of three VSG mRNAs expressed in a mixed population of
RT   Trypanosoma brucei rhodesiense.";
RL   Biochem. Biophys. Res. Commun. 169:730-736(1990).
CC   -!- FUNCTION: VSG forms a coat on the surface of the parasite. The
CC       trypanosome evades the immune response of the host by expressing a
CC       series of antigenically distinct VSGs from an estimated 1000 VSG genes.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor. Note=A
CC       soluble form is released from ruptured cells by the action of a PI-PLC.
CC       {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M33824; AAA30317.1; -; mRNA.
DR   PIR; B35480; B35480.
DR   AlphaFoldDB; P20947; -.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR025932; Trypano_VSG_B_N_dom.
DR   InterPro; IPR027446; VSG_C_dom_sf.
DR   Pfam; PF13206; VSG_B; 1.
DR   SUPFAM; SSF118251; SSF118251; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane; Signal;
KW   Trypanosomiasis.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..470
FT                   /note="Variant surface glycoprotein WRATAT B"
FT                   /id="PRO_0000036449"
FT   PROPEP          471..487
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000036450"
FT   REGION          443..468
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           470
FT                   /note="GPI-anchor amidated serine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        71
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        84
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        418
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        465
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   487 AA;  52724 MW;  7710C7B130BA39DA CRC64;
     MWIILALLTL AGSRVAHGAG KNVNGVEFNL FCHIANMLNA EKIEDDKTDG LDRQAAEAWT
     AIDSIFTVTA NESYYSEGPA SAANTTDENQ DAKPERVAKW VQKRNQIDKI AAPGNEKNGK
     YARRPRDRMS AATGAKLDTV FTLASEARVR LMQIDTEIAT NKQEIRQQLG LHCSEGQGKG
     QSRNQHPDNA AFASDYSTAC KGSTGPGKSL ANDLVCICST DTSQAQSTLQ MCTSIDDANS
     LFSTLHKRSQ CQGDFPCPHR VCAKTAETSE LTETNINNCV TAFTATLGRH TKSSATNEGA
     YVFGSGQNSG DECNGGAATG QSCVSYHDLI TAKSGTTLSG AITRLKQLQI AKAKLKARRL
     LLQNRERQQT RLMALADKMQ ELYQEALHDE VQLRKEAQNK PQETPDSDKQ KACEKYHNKS
     KECKENGCQW SGTEETIGKC EAKPKAGTEA ATTGPGERDA GATANTTGSS NSFVIKTSPL
     LFAFLLF