ID   VSX1_BOVIN              Reviewed;         365 AA.
AC   Q9GMA3;
DT   08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 132.
DE   RecName: Full=Visual system homeobox 1;
DE   AltName: Full=Homeodomain protein RINX;
DE   AltName: Full=Retinal inner nuclear layer homeobox protein;
DE   AltName: Full=Transcription factor VSX1;
GN   Name=VSX1; Synonyms=RINX;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Retina;
RX   PubMed=10903837; DOI=10.1006/geno.2000.6248;
RA   Hayashi T., Huang J., Deeb S.S.;
RT   "RINX(VSX1), a novel homeobox gene expressed in the inner nuclear layer of
RT   the adult retina.";
RL   Genomics 67:128-139(2000).
CC   -!- FUNCTION: Binds to the 37-bp core of the locus control region (LCR) of
CC       the red/green visual pigment gene cluster (By similarity). May regulate
CC       the activity of the LCR and the cone opsin genes at earlier stages of
CC       development (By similarity). Dispensable in early retinal development
CC       (By similarity). {ECO:0000250|UniProtKB:Q91V10}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q91V10}.
CC   -!- TISSUE SPECIFICITY: Expressed in a subset of cells in the inner nuclear
CC       layer of the retina.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000305}.
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DR   EMBL; AF251032; AAF99655.1; -; mRNA.
DR   RefSeq; NP_777192.1; NM_174767.2.
DR   AlphaFoldDB; Q9GMA3; -.
DR   SMR; Q9GMA3; -.
DR   STRING; 9913.ENSBTAP00000004329; -.
DR   PaxDb; Q9GMA3; -.
DR   GeneID; 286802; -.
DR   KEGG; bta:286802; -.
DR   CTD; 30813; -.
DR   eggNOG; KOG0494; Eukaryota.
DR   HOGENOM; CLU_049243_1_0_1; -.
DR   InParanoid; Q9GMA3; -.
DR   OrthoDB; 1348807at2759; -.
DR   TreeFam; TF350743; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0048666; P:neuron development; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR023339; CVC.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS51496; CVC; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Sensory transduction; Transcription; Transcription regulation; Vision.
FT   CHAIN           1..365
FT                   /note="Visual system homeobox 1"
FT                   /id="PRO_0000049354"
FT   DOMAIN          224..277
FT                   /note="CVC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00829"
FT   DNA_BIND        164..223
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..65
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          114..169
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          294..365
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           31..38
FT                   /note="Octapeptide motif"
FT   MOTIF           161..166
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        136..156
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        325..341
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   365 AA;  38526 MW;  18B2CC0CA801713A CRC64;
     MTGRDALSDG RARSRALVPG GPSTGSRPRG FAITDLLGLE AELPAPEGPG PGSGCEGPAA
     APRAGPGLGG SCPARGALPL GLGLLCGFGA QPPAAARAPC LLLADVPFLP PEGPEPLAPR
     FPGRPPPSAA RQKRSESVST SDEDSPSEDR SDRKASPAPS KRKKRRHRTV FTAHQLEELE
     KAFSEAHYPD VYAREMLAMK TELPEDRIQV WFQNRRAKWR KREKRWGGSS VMAEYGLYGA
     MVRHCIPLPD SVLGSGEGGL LGSCAPWLLG MHKKSAGTIR KAESEEKLAG LWGSDHLKEG
     SSPHQAGPQR GLEEGSPVSG VEDVVIDLSS STRQETDRAQ QGVGAQGRPD SEGLEGLQPG
     KEGAL