ID   VSX1_CARAU              Reviewed;         341 AA.
AC   Q90277;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Visual system homeobox 1;
DE   AltName: Full=Homeobox protein VSX-1;
DE   AltName: Full=Transcription factor VSX1;
GN   Name=vsx1;
OS   Carassius auratus (Goldfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Carassius.
OX   NCBI_TaxID=7957;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Retina;
RX   PubMed=7836564; DOI=10.1002/cne.903480409;
RA   Levine E.M., Hitchcock P.F., Glasgow E., Schechter N.;
RT   "Restricted expression of a new paired-class homeobox gene in normal and
RT   regenerating adult goldfish retina.";
RL   J. Comp. Neurol. 348:596-606(1994).
RN   [2]
RP   INTERACTION WITH UBE2I, AND NUCLEAR LOCALIZATION SIGNAL.
RX   PubMed=11331779; DOI=10.1073/pnas.101129698;
RA   Kurtzman A.L., Schechter N.;
RT   "Ubc9 interacts with a nuclear localization signal and mediates nuclear
RT   localization of the paired-like homeobox protein Vsx-1 independent of SUMO-
RT   1 modification.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:5602-5607(2001).
CC   -!- FUNCTION: May stabilize the differentiated state of a subset of cells
CC       in the inner nuclear layer and may be involved in cellular
CC       differentiation during retinal development and regeneration.
CC   -!- SUBUNIT: Interacts with UBE2I. {ECO:0000269|PubMed:11331779}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O42250}.
CC   -!- TISSUE SPECIFICITY: Restricted to the neural retina.
CC   -!- DOMAIN: The NLS interacts with UBE2I.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000305}.
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DR   EMBL; U07056; AAC24600.1; -; mRNA.
DR   AlphaFoldDB; Q90277; -.
DR   SMR; Q90277; -.
DR   Proteomes; UP000515129; Genome assembly.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR023339; CVC.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS51496; CVC; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   1: Evidence at protein level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Sensory transduction; Transcription; Transcription regulation; Vision.
FT   CHAIN           1..341
FT                   /note="Visual system homeobox 1"
FT                   /id="PRO_0000049359"
FT   DOMAIN          208..265
FT                   /note="CVC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00829"
FT   DNA_BIND        148..207
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          127..151
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          262..341
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           37..44
FT                   /note="Octapeptide motif"
FT   MOTIF           147..151
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000269|PubMed:11331779"
FT   COMPBIAS        127..142
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        323..341
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   341 AA;  37512 MW;  05680449D9399A14 CRC64;
     MTGREEAIDE KPKVKLYPSF GIDKARLNGS GFRSKGFAIT DLLGLESDLQ PHQSGSGAGA
     NGEGQSAALG GFAFPGGSLP IGLGFLCSLA AQQPPGAPCF LPSHIPLLQP RTESHFMQNL
     EQQRDAYSDD DCLSGDRNDG KNSQKRKKRR HRTVFTSHQL EELEKAFHEA HYPDVYAREM
     LAMKTELPED RIQVWFQNRR AKWRKREKCW GRSSVMAEYG LYGAMVRHSI PLPESIINSA
     KNGMMGSCAP WLLGEPAGMH KKSLEIGKNP PGTPESTHSD SYSEEHKVKD SDTTWSSGAN
     GADDSEDMAI DLSSTSKQES KSTLKRSPPH TEDSSDSETE S