VSX1_DANRE
ID VSX1_DANRE Reviewed; 344 AA.
AC O42250;
DT 08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 2.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Visual system homeobox 1;
DE AltName: Full=Transcription factor VSX1;
GN Name=vsx1;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Retina;
RX PubMed=9770270;
RX DOI=10.1002/(sici)1520-6408(1998)23:2<128::aid-dvg5>3.0.co;2-8;
RA Passini M.A., Kurtzman A.L., Canger A.K., Asch W.S., Wray G.A.,
RA Raymond P.A., Schechter N.;
RT "Cloning of zebrafish vsx1: expression of a paired-like homeobox gene
RT during CNS development.";
RL Dev. Genet. 23:128-141(1998).
RN [2]
RP INTERACTION WITH UBE2I, SUBCELLULAR LOCATION, AND NUCLEAR LOCALIZATION
RP SIGNAL.
RX PubMed=11331779; DOI=10.1073/pnas.101129698;
RA Kurtzman A.L., Schechter N.;
RT "Ubc9 interacts with a nuclear localization signal and mediates nuclear
RT localization of the paired-like homeobox protein Vsx-1 independent of SUMO-
RT 1 modification.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:5602-5607(2001).
CC -!- FUNCTION: May be involved in maintenance as well as cellular
CC differentiation of retinal interneurons, such as bipolar cells. May
CC play a role in establishing interneuronal cell classes in nonsensory as
CC well as sensory systems.
CC -!- SUBUNIT: Interacts with UBE2I. {ECO:0000269|PubMed:11331779}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC ECO:0000269|PubMed:11331779}.
CC -!- TISSUE SPECIFICITY: Highly expressed in the central and outer tiers of
CC the inner nuclear layer of the retina.
CC -!- DEVELOPMENTAL STAGE: Significant levels were first detected at the 14-
CC somite stage (16 hours post-fertization; hpf) and increased by the
CC prim-11 stage (28 hpf). At 16 hpf expression is observed in a small
CC subset of neurons in the spinal cord and at 18 hpf in the developing
CC hindbrain. At 28-32 hpf, significant levels of expression is seen in
CC presumptive neurons along the rostral-caudal axis of the hindbrain and
CC the spinal cord. During later stages of development expression is
CC restricted to the developing retina and no longer detected in the
CC hindbrain or spinal cord.
CC -!- DOMAIN: The NLS interacts with UBE2I.
CC -!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000305}.
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DR EMBL; AF025348; AAB71611.2; -; mRNA.
DR RefSeq; NP_571408.1; NM_131333.1.
DR AlphaFoldDB; O42250; -.
DR SMR; O42250; -.
DR STRING; 7955.ENSDARP00000073224; -.
DR PaxDb; O42250; -.
DR GeneID; 30598; -.
DR KEGG; dre:30598; -.
DR CTD; 30813; -.
DR ZFIN; ZDB-GENE-990415-205; vsx1.
DR eggNOG; KOG0494; Eukaryota.
DR InParanoid; O42250; -.
DR OrthoDB; 1348807at2759; -.
DR PhylomeDB; O42250; -.
DR PRO; PR:O42250; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IDA:ZFIN.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IDA:ZFIN.
DR GO; GO:0048318; P:axial mesoderm development; IMP:ZFIN.
DR GO; GO:0030900; P:forebrain development; IMP:ZFIN.
DR GO; GO:0048329; P:negative regulation of axial mesodermal cell fate specification; IMP:ZFIN.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:ZFIN.
DR GO; GO:0048339; P:paraxial mesoderm development; IMP:ZFIN.
DR GO; GO:0048348; P:paraxial mesodermal cell fate specification; IMP:ZFIN.
DR GO; GO:0021501; P:prechordal plate formation; IMP:ZFIN.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR023339; CVC.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS51496; CVC; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Sensory transduction; Transcription; Transcription regulation; Vision.
FT CHAIN 1..344
FT /note="Visual system homeobox 1"
FT /id="PRO_0000049358"
FT DOMAIN 211..268
FT /note="CVC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00829"
FT DNA_BIND 151..210
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 37..44
FT /note="Octapeptide motif"
FT REGION 49..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 127..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 273..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 147..151
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000269|PubMed:11331779"
FT COMPBIAS 127..145
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 326..344
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 344 AA; 37872 MW; 5CA3C631D2F8E7F6 CRC64;
MTGREEATDE KPKVKLYPSF GIDKSRLNGS GFRSKGFAIT DLLGLESELQ PHQSGPGAGP
NGEGQSAAVG GFSFPGGSLP LGLGFLCSLA AQQPPGAPCF LPSHIPLLQS RTESHFMQNL
EQQRDVYSDD DCLSGDRNDG KNSGNSQKRK KRRHRTVFTS HQLEELEKAF NEAHYPDVYA
REMLAMKTEL PEDRIQVWFQ NRRAKWRKRE KCWGRSSVMA EYGLYGAMVR HSIPLPESII
NSAKSGMMGS CAPWLLGEPA GMHKKSMEIV KKAPGTPEST HSDTYSEEHK GKDSDTTWSS
GANGADDSED MAIDLSSTSK QENKSTLKRS PPRTENSSDS ENES
