VSX2_CHICK
ID VSX2_CHICK Reviewed; 377 AA.
AC Q9IAL1;
DT 08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Visual system homeobox 2;
DE AltName: Full=Ceh-10 homeodomain-containing homolog;
DE AltName: Full=Homeobox protein CHX10;
GN Name=VSX2; Synonyms=CHX10;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10640715; DOI=10.1016/s0925-4773(99)00251-8;
RA Chen C.-M.A., Cepko C.L.;
RT "Expression of Chx10 and Chx10-1 in the developing chicken retina.";
RL Mech. Dev. 90:293-297(2000).
RN [2]
RP FUNCTION.
RX PubMed=27477290; DOI=10.1016/j.celrep.2016.06.100;
RA Clovis Y.M., Seo S.Y., Kwon J.S., Rhee J.C., Yeo S., Lee J.W., Lee S.,
RA Lee S.K.;
RT "Chx10 Consolidates V2a Interneuron Identity through Two Distinct Gene
RT Repression Modes.";
RL Cell Rep. 16:1642-1652(2016).
CC -!- FUNCTION: Acts as a transcriptional regulator (By similarity). Plays a
CC significant role in the specification and morphogenesis of the sensory
CC retina (By similarity). Mediates differentiation of V2a interneurons by
CC repression of motor neuron gene transcription, via competitively
CC binding to response elements that are activated by the ISL1-LHX3
CC complex (PubMed:27477290). May also participate in the development of
CC the cells of the inner nuclear layer, particularly bipolar cells (By
CC similarity). {ECO:0000250|UniProtKB:Q61412,
CC ECO:0000269|PubMed:27477290}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q61412}.
CC -!- TISSUE SPECIFICITY: Retina and spinal cord.
CC -!- DEVELOPMENTAL STAGE: Expressed throughout the invaginating optic
CC vesicles at stage 12, and uniformly throughout the neural retina from
CC stage 14 to stage 18. Expressed in the spinal cord from stage 15 to
CC stage 20.
CC -!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000305}.
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DR EMBL; AF178671; AAF40313.1; -; mRNA.
DR RefSeq; NP_990099.1; NM_204768.1.
DR AlphaFoldDB; Q9IAL1; -.
DR SMR; Q9IAL1; -.
DR STRING; 9031.ENSGALP00000016587; -.
DR PaxDb; Q9IAL1; -.
DR Ensembl; ENSGALT00000049214; ENSGALP00000048165; ENSGALG00000033517.
DR GeneID; 395536; -.
DR KEGG; gga:395536; -.
DR CTD; 338917; -.
DR VEuPathDB; HostDB:geneid_395536; -.
DR eggNOG; KOG0494; Eukaryota.
DR GeneTree; ENSGT00940000157776; -.
DR HOGENOM; CLU_049243_0_0_1; -.
DR InParanoid; Q9IAL1; -.
DR OMA; QDVHLQP; -.
DR OrthoDB; 1348807at2759; -.
DR PhylomeDB; Q9IAL1; -.
DR TreeFam; TF350743; -.
DR PRO; PR:Q9IAL1; -.
DR Proteomes; UP000000539; Chromosome 5.
DR ExpressionAtlas; Q9IAL1; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR023339; CVC.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR003654; OAR_dom.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF03826; OAR; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS51496; CVC; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS50803; OAR; 1.
PE 2: Evidence at transcript level;
KW Activator; Developmental protein; DNA-binding; Homeobox; Nucleus;
KW Reference proteome; Repressor; Sensory transduction; Transcription;
KW Transcription regulation; Vision.
FT CHAIN 1..377
FT /note="Visual system homeobox 2"
FT /id="PRO_0000049364"
FT DOMAIN 227..280
FT /note="CVC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00829"
FT DNA_BIND 167..226
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 129..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 285..377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 323..336
FT /note="OAR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00138"
FT COMPBIAS 21..39
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..145
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 285..317
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 348..377
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 377 AA; 40645 MW; 1FCD9EF4664A3C21 CRC64;
MTGKAGAALA PSLPGKPKPD GAAAAAPPPP PPAAGAKPSS GPTPPRCTGF GIQEILGLNK
EPPSHPRAAL DSLPAGHLLA ARSVLSPAGV GGVGMGLLGA GGIPGFYAQP TFLEVLSDPQ
SVHLQPLARA PGQLDSSQTA SSDSEDVSSS DRKMSKSSLN QSKKRKKRRH RTIFTSYQLE
ELEKAFNEAH YPDVYAREML AMKTELPEDR IQVWFQNRRA KWRKREKCWG RSSVMAEYGL
YGAMVRHSIP LPESILKSAK DGIMESCAPW LLGMHKKSLE AAAEAGRKTE VERQALPKLD
KGDKEERGSD PKTAISQEEL RENSIAALRA KAQEHSTKVL GTIAGDTPRK PEKGEEVAED
ERQTEKSSAS QKEEKLI
