ID   VSX2_ORYLA              Reviewed;         393 AA.
AC   Q9I9A3;
DT   08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Visual system homeobox 2;
DE   AltName: Full=Ceh-10 homeodomain-containing homolog;
DE   AltName: Full=Homeobox protein CHX10;
DE   AltName: Full=Transcription factor VSX2;
GN   Name=vsx2; Synonyms=chx10;
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=8090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Embryo;
RX   PubMed=10751179; DOI=10.1242/dev.127.9.1911;
RA   Winkler S., Loosli F., Henrich T., Wakamatsu Y., Wittbrodt J.;
RT   "The conditional medaka mutation eyeless uncouples patterning and
RT   morphogenesis of the eye.";
RL   Development 127:1911-1919(2000).
CC   -!- FUNCTION: Acts as a transcriptional regulator (By similarity). Mediates
CC       the differentiation of V2a interneurons (By similarity). Plays a role
CC       in eye development and organization of the neuroretina (By similarity).
CC       {ECO:0000250|UniProtKB:O42477, ECO:0000250|UniProtKB:Q61412}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q61412}.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AJ250404; CAB88702.1; -; mRNA.
DR   RefSeq; NP_001098336.1; NM_001104866.1.
DR   AlphaFoldDB; Q9I9A3; -.
DR   SMR; Q9I9A3; -.
DR   STRING; 8090.ENSORLP00000020883; -.
DR   Ensembl; ENSORLT00000020884; ENSORLP00000020883; ENSORLG00000016694.
DR   GeneID; 100049516; -.
DR   KEGG; ola:100049516; -.
DR   CTD; 338917; -.
DR   eggNOG; KOG0494; Eukaryota.
DR   GeneTree; ENSGT00940000157776; -.
DR   InParanoid; Q9I9A3; -.
DR   OrthoDB; 1348807at2759; -.
DR   Proteomes; UP000001038; Chromosome 22.
DR   Proteomes; UP000265180; Unplaced.
DR   Proteomes; UP000265200; Unplaced.
DR   Bgee; ENSORLG00000016694; Expressed in testis and 6 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR023339; CVC.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR003654; OAR_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF03826; OAR; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS51496; CVC; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS50803; OAR; 1.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; DNA-binding; Homeobox; Nucleus;
KW   Reference proteome; Repressor; Sensory transduction; Transcription;
KW   Transcription regulation; Vision.
FT   CHAIN           1..393
FT                   /note="Visual system homeobox 2"
FT                   /id="PRO_0000049361"
FT   DOMAIN          222..296
FT                   /note="CVC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00829"
FT   DNA_BIND        162..221
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          121..165
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          304..393
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           44..51
FT                   /note="Octapeptide motif"
FT   MOTIF           147..151
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   MOTIF           341..354
FT                   /note="OAR"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00138"
FT   COMPBIAS        126..140
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        317..343
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   393 AA;  42987 MW;  57ECB5B329A62E93 CRC64;
     MTGKQGVALS ESLNPAEKTS LVINGGSLQP KISATNPPPR CTGFGIQEIL GLNKEPATAP
     RSPLSALPAG AHLIAARSVL GPAGVGVGMG LIGPAGIPSF YSQPAFLETV LADGHDVRLQ
     PHNRSARPLD ANQSVSSDSE DLSSSERKLS KSSVNQSKKR KKRRHRTIFT SYQLEELEKA
     FNEAHYPDVY AREMLAMKTE LPEDRIQVWF QNRRAKWRKR EKCWGRSTVM AEYGLYGAMV
     RHSIPLPESI LKSAKDGIME SCAPWLLVQD GLPINRRYSK SEYPQLFAGM HKKSMEAANL
     PATAKCDAPQ QPSAQRSEDV EAEEKRSDGK STISKEEMRE NSIAALRAKA QEHSAKVLGT
     VSPGKLLEGK QEKQAVGEKV SEPPSPTEEQ KSP