VSXL2_MOUSE
ID VSXL2_MOUSE Reviewed; 776 AA.
AC A0A140LHF2;
DT 05-JUL-2017, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2016, sequence version 2.
DT 03-AUG-2022, entry version 27.
DE RecName: Full=V-set and immunoglobulin domain-containing protein 10-like 2 {ECO:0000250|UniProtKB:P0DP72};
DE Flags: Precursor;
GN Name=Vsig10l2 {ECO:0000250|UniProtKB:P0DP72};
GN Synonyms=Gm1113 {ECO:0000312|MGI:MGI:2685959};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC protein {ECO:0000255}.
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DR EMBL; AC118232; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A140LHF2; -.
DR GlyGen; A0A140LHF2; 2 sites.
DR ProteomicsDB; 297827; -.
DR Ensembl; ENSMUST00000183573; ENSMUSP00000146390; ENSMUSG00000098590.
DR MGI; MGI:2685959; Gm1113.
DR VEuPathDB; HostDB:ENSMUSG00000098590; -.
DR GeneTree; ENSGT00940000163088; -.
DR OMA; DPVNRTH; -.
DR PRO; PR:A0A140LHF2; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; A0A140LHF2; protein.
DR Bgee; ENSMUSG00000098590; Expressed in white adipose tissue.
DR GO; GO:0005911; C:cell-cell junction; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0050839; F:cell adhesion molecule binding; IBA:GO_Central.
DR GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; -; 5.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 4.
DR SUPFAM; SSF48726; SSF48726; 4.
DR SUPFAM; SSF49265; SSF49265; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50835; IG_LIKE; 4.
PE 3: Inferred from homology;
KW Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..28
FT /evidence="ECO:0000255"
FT CHAIN 29..776
FT /note="V-set and immunoglobulin domain-containing protein
FT 10-like 2"
FT /evidence="ECO:0000255"
FT /id="PRO_5008865835"
FT TRANSMEM 713..733
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 32..140
FT /note="Ig-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 150..234
FT /note="Ig-like 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 242..324
FT /note="Ig-like 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 399..498
FT /note="Ig-like 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 500..592
FT /note="Ig-like 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 608..708
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT CARBOHYD 611
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 637
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 56..122
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 169..217
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 268..308
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 435..480
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 521..576
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 776 AA; 83270 MW; 8F29475B99292826 CRC64;
MVGLSAHHRP LGCRLLILFC LLHPGASGQP YPTSNTAGEE ALSVQGVRGS SVELECRTGP
APMAVLWSFT PLGSLVLQPV AVTSGASSKV ESGALALGVV SLRNSSLVIE ELREGARGHF
LCQTLLVSGG QVHTAYLYLM LTVLVPVSKP RVQLNDPSPV EGVSVVATCA VREGTEPLTF
SWHHHMPQGP GEVLVGLSEP RLQLDPVNRT HLGWYTCSVS NVVNQLKSDG AFLDVIYGPD
KPVITVEPLG FSEDGFWASE REEVTLSCLA ASNPPSHYVW FRDDSQIHTG PTYIIASASR
THTGLYTCLA HNRHLDTHTQ TTVQLIIYYP PEGQPSCAVL PTLGVVTLLC TWPGGFPNAQ
LHWEGPQGIG PSASGNVTWS YTTTGLPNGS IFSCTGQHPT LAMPIFCRVT LWEPPGSPTC
WTTATVGDQY IMLSCEWPGG EPPAMLSWLD RQQSLGDLGS SQAVHLLQAQ SDLAGREFTC
QGSHPLTAPG SHCRLRLEVP QLTVAEPRVS VLEGEEAWLG CALQRGTPPA QLLWLGPQQQ
QLEGSTPGFI LHPEGTHLRL QVRDADPAHH RGTYQCVARN ALGNSSQSVL LEVLSECKGF
VCPCGYPTPP NVTISRLTYR RQRREVQLQW AIYGPGNLTG FLVQQRASVP SSEAGAWEVA
ASDIEPESRD RRLGGLDPGV LYAFRILAMN HHTAGYPSEV KTPVDPAFSA YPAVLGAAGT
GVVVALATSL LVFQYAARHP HTFPCTETAS TTSSSDPIQE SIDAPVNVTI TVTATP
