ID   VSY1_TRYCO              Reviewed;         419 AA.
AC   P20948;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Variant surface glycoprotein YnAT 1.1;
DE            Short=VSG;
DE   Flags: Precursor;
OS   Trypanosoma congolense.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Nannomonas.
OX   NCBI_TaxID=5692;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RC   STRAIN=YnAT 1.1;
RX   PubMed=3567147; DOI=10.1021/bi00377a021;
RA   Strickler J.E., Binder D.A., L'Italien J.J., Shimamoto G.T., Wait S.W.,
RA   Dalheim L.J., Novotny J., Radding J.A., Konigsberg W.H., Armstrong M.Y.K.,
RA   Richards F.F., Lalor T.M.;
RT   "Trypanosoma congolense: structure and molecular organization of the
RT   surface glycoproteins of two early bloodstream variants.";
RL   Biochemistry 26:796-805(1987).
CC   -!- FUNCTION: VSG forms a coat on the surface of the parasite. The
CC       trypanosome evades the immune response of the host by expressing a
CC       series of antigenically distinct VSGs from an estimated 1000 VSG genes.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor. Note=A
CC       soluble form is released from ruptured cells by the action of a PI-PLC.
CC       {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M15112; AAA30298.1; -; mRNA.
DR   PIR; A27539; A27539.
DR   AlphaFoldDB; P20948; -.
DR   VEuPathDB; TriTrypDB:TcIL3000.A.H_000077000; -.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR025932; Trypano_VSG_B_N_dom.
DR   Pfam; PF13206; VSG_B; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Direct protein sequencing; Glycoprotein; GPI-anchor;
KW   Lipoprotein; Membrane; Signal; Trypanosomiasis.
FT   SIGNAL          1..28
FT   CHAIN           29..400
FT                   /note="Variant surface glycoprotein YnAT 1.1"
FT                   /id="PRO_0000036453"
FT   PROPEP          401..419
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000036454"
FT   REGION          369..405
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           400
FT                   /note="GPI-anchor amidated serine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        82
FT                   /note="N-linked (GlcNAc...) asparagine"
FT   CARBOHYD        358
FT                   /note="N-linked (GlcNAc...) asparagine"
FT   CARBOHYD        379
FT                   /note="N-linked (GlcNAc...) (high mannose) asparagine"
SQ   SEQUENCE   419 AA;  44767 MW;  F1BC1F8C639CDF02 CRC64;
     MKRVLSNVLK AWIFTIVAFH NFSTSVTADA PVNAAEYNAL CRLYNIARAG EGLKEEDWLP
     CAGKAACEKT AASIEDVFMK LNFSEPSAVV TTLDGTRVEL QNSASTRIKR AKLAKVLAAA
     ETIKAQQLKY HESSKSLLES AKANFTKAIV GGWGNPTTPD ESGLPTTFKT NRADDCKLAG
     GNGGKSLVFD IACLCTTSDS ASGSKYTCGP KSGDNGSGWL DNNGDNQGKP AAKEAWKNLR
     ADCRRQSAGV RVTPELISQS LVIFEGLIGT RAASGHDNAR YIFGTVATAQ SCGHSTATNK
     GSIDYKASNA QQRGDIEWEK NLRMAEGDLR GLLTAKQLVA ALQARAEHLE DAAFTIFNES
     VLETQIAWES SRPPSTDANT SQKGPLQRPE KSGESSHLPS GSSHGTKAIR SILHVALLM