ID   VSY3_TRYCO              Reviewed;         413 AA.
AC   P20949;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Variant surface glycoprotein YnAT 1.3;
DE            Short=VSG;
DE   Flags: Precursor;
OS   Trypanosoma congolense.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Nannomonas.
OX   NCBI_TaxID=5692;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RC   STRAIN=YnAT 1.3;
RX   PubMed=3567147; DOI=10.1021/bi00377a021;
RA   Strickler J.E., Binder D.A., L'Italien J.J., Shimamoto G.T., Wait S.W.,
RA   Dalheim L.J., Novotny J., Radding J.A., Konigsberg W.H., Armstrong M.Y.K.,
RA   Richards F.F., Lalor T.M.;
RT   "Trypanosoma congolense: structure and molecular organization of the
RT   surface glycoproteins of two early bloodstream variants.";
RL   Biochemistry 26:796-805(1987).
CC   -!- FUNCTION: VSG forms a coat on the surface of the parasite. The
CC       trypanosome evades the immune response of the host by expressing a
CC       series of antigenically distinct VSGs from an estimated 1000 VSG genes.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor. Note=A
CC       soluble form is released from ruptured cells by the action of a PI-PLC.
CC       {ECO:0000250}.
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DR   EMBL; M15113; AAA30300.1; -; mRNA.
DR   PIR; B27539; B27539.
DR   AlphaFoldDB; P20949; -.
DR   VEuPathDB; TriTrypDB:TcIL3000.A.H_000164400; -.
DR   VEuPathDB; TriTrypDB:TcIL3000_0_58790; -.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR025932; Trypano_VSG_B_N_dom.
DR   Pfam; PF13206; VSG_B; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Direct protein sequencing; Glycoprotein; GPI-anchor;
KW   Lipoprotein; Membrane; Signal; Trypanosomiasis.
FT   SIGNAL          1..22
FT   CHAIN           23..379
FT                   /note="Variant surface glycoprotein YnAT 1.3"
FT                   /id="PRO_0000036455"
FT   PROPEP          380..413
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000036456"
FT   LIPID           379
FT                   /note="GPI-anchor amidated asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        91
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        361
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        379
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   413 AA;  44324 MW;  C6D5E747D587233B CRC64;
     MLDNSRARSI VHLLILLKAH VITQIIKNTQ EFTSLCTFVK VTLKATDGLT SAASKSQTDW
     ALGENPTSRI KKLITELETS SDRIRLGEEP NLTIQLPQGD PKQRLRRKLE VFLARAKYTE
     ELVRQAQGDV GGRCNEAKAE LEEAVTGRKG PDLETQATAA AAALHNKARG TACKVAGATT
     DTNFAGTSLV ADLMCLCAAE TNSREKHICG FESHASGVWA NAGTNSNAGE IWGKILDACK
     NREIQVEVTP QFLRIAITKF EGLLGAQAHK LTSNGNAGAW LLGYSMNAGS VTCDGQSSTN
     GICVDYKGSS DARGPIAWLG HIKNAITALE NRDKNLQRVR KLQRQAEAIL MSAEDALIEA
     NISLGGKDMV PASEVTVPNS SNPTSRQNSV VQEPTTVSAA AITPLILPWT LLI