ID   VT2_MYXVL               Reviewed;         326 AA.
AC   P29825;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Tumor necrosis factor soluble receptor;
DE   AltName: Full=Protein T2;
DE   Flags: Precursor;
GN   OrderedLocusNames=m002L; ORFNames=T2;
OS   Myxoma virus (strain Lausanne) (MYXV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Leporipoxvirus.
OX   NCBI_TaxID=31530;
OH   NCBI_TaxID=9986; Oryctolagus cuniculus (Rabbit).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1651597; DOI=10.1016/0042-6822(91)90853-4;
RA   Upton C., Macen J.L., Schreiber M., McFadden G.;
RT   "Myxoma virus expresses a secreted protein with homology to the tumor
RT   necrosis factor receptor gene family that contributes to viral virulence.";
RL   Virology 184:370-382(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10562494; DOI=10.1006/viro.1999.0001;
RA   Cameron C., Hota-Mitchell S., Chen L., Barrett J.W., Cao J.-X.,
RA   Macaulay C., Willer D.O., Evans D.H., McFadden G.;
RT   "The complete DNA sequence of myxoma virus.";
RL   Virology 264:298-318(1999).
CC   -!- FUNCTION: Binds to TNF-alpha and beta. Probably prevents TNF to reach
CC       cellular target and thereby deampening the potential antiviral effects
CC       of the cytokine.
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DR   EMBL; M95181; AAA46632.1; -; Genomic_DNA.
DR   EMBL; AF170726; AAF15046.1; -; Genomic_DNA.
DR   EMBL; AF170726; AAF14887.1; -; Genomic_DNA.
DR   PIR; A40566; GQVZML.
DR   RefSeq; NP_051713.1; NC_001132.2.
DR   RefSeq; NP_051879.1; NC_001132.2.
DR   SMR; P29825; -.
DR   PRIDE; P29825; -.
DR   GeneID; 1670230; -.
DR   GeneID; 932138; -.
DR   KEGG; vg:1670230; -.
DR   KEGG; vg:932138; -.
DR   Proteomes; UP000000867; Genome.
DR   GO; GO:0005031; F:tumor necrosis factor receptor activity; IEA:InterPro.
DR   CDD; cd15839; TNFRSF_viral; 1.
DR   InterPro; IPR010806; Poxvirus_TNF-rcpt-II_C.
DR   InterPro; IPR011172; Poxvirus_TNF_rcpt-II.
DR   InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR   InterPro; IPR034059; TNFRSF_N_viral.
DR   Pfam; PF07190; DUF1406; 1.
DR   Pfam; PF00020; TNFR_c6; 2.
DR   PIRSF; PIRSF001790; TNF_C22L; 1.
DR   SMART; SM00208; TNFR; 3.
DR   PROSITE; PS00652; TNFR_NGFR_1; 2.
DR   PROSITE; PS50050; TNFR_NGFR_2; 2.
PE   3: Inferred from homology;
KW   Disulfide bond; Glycoprotein; Receptor; Reference proteome; Repeat; Signal;
KW   Virulence.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..326
FT                   /note="Tumor necrosis factor soluble receptor"
FT                   /id="PRO_0000034613"
FT   REPEAT          27..62
FT                   /note="TNFR-Cys 1"
FT   REPEAT          63..104
FT                   /note="TNFR-Cys 2"
FT   REPEAT          105..147
FT                   /note="TNFR-Cys 3"
FT   REPEAT          148..186
FT                   /note="TNFR-Cys 4"
FT   CARBOHYD        66
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        181
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        205
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        238
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   DISULFID        28..39
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        40..53
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        43..61
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        64..79
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        82..96
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        86..104
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        106..120
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        123..146
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        129..149
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        164..185
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
SQ   SEQUENCE   326 AA;  35208 MW;  ABBF027E947292FF CRC64;
     MFRLTLLLAY VACVYGGGAP YGADRGKCRG NDYEKDGLCC TSCPPGSYAS RLCGPGSDTV
     CSPCKNETFT ASTNHAPACV SCRGRCTGHL SESQSCDKTR DRVCDCSAGN YCLLKGQEGC
     RICAPKTKCP AGYGVSGHTR TGDVLCTKCP RYTYSDAVSS TETCTSSFNY ISVEFNLYPV
     NDTSCTTTAG PNEVVKTSEF SVTLNHTDCD PVFHTEYYGT SGSEGAGGFF TGMDRYQNTT
     KMCTLNIEIR CVEGDAVRTI PRTSDGVGVL SHSETITVIG GCLSDVNVDI EYSDSNHPEE
     VDDFVEYHWG TRLRLFPSPK RCRLVS