ID   VT2_RFVKA               Reviewed;         325 AA.
AC   P25943; Q77PB3;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1992, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Tumor necrosis factor soluble receptor;
DE   AltName: Full=Protein T2;
DE   Flags: Precursor;
GN   ORFNames=s002L, s002R, T2;
OS   Rabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain
OS   Kasza)).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Leporipoxvirus.
OX   NCBI_TaxID=10272;
OH   NCBI_TaxID=9986; Oryctolagus cuniculus (Rabbit).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2820128; DOI=10.1016/0042-6822(87)90039-0;
RA   Upton C., Delange A.M., McFadden G.;
RT   "Tumorigenic poxviruses: genomic organization and DNA sequence of the
RT   telomeric region of the Shope fibroma virus genome.";
RL   Virology 160:20-30(1987).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX   PubMed=1850261; DOI=10.1016/0006-291x(91)90929-2;
RA   Smith C.A., Davis T., Wignall J.M., Din W.S., Farrah T., Upton C.,
RA   McFadden G., Goodwin R.G.;
RT   "T2 open reading frame from the Shope fibroma virus encodes a soluble form
RT   of the TNF receptor.";
RL   Biochem. Biophys. Res. Commun. 176:335-342(1991).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1660196; DOI=10.1016/0042-6822(91)90529-k;
RA   Strayer D.S., Jerng H.H., O'Connor K.;
RT   "Sequence and analysis of a portion of the genomes of Shope fibroma virus
RT   and malignant rabbit fibroma virus that is important for viral replication
RT   in lymphocytes.";
RL   Virology 185:585-595(1991).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10562495; DOI=10.1006/viro.1999.0002;
RA   Willer D.O., McFadden G., Evans D.H.;
RT   "The complete genome sequence of shope (Rabbit) fibroma virus.";
RL   Virology 264:319-343(1999).
CC   -!- FUNCTION: Binds to TNF-alpha and beta. Probably prevents TNF to reach
CC       cellular target and thereby deampening the potential antiviral effects
CC       of the cytokine. {ECO:0000269|PubMed:1850261}.
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DR   EMBL; M17433; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AF170722; AAF17884.1; -; Genomic_DNA.
DR   EMBL; AF170722; AAF18043.1; -; Genomic_DNA.
DR   PIR; B43692; B43692.
DR   RefSeq; NP_051887.1; NC_001266.1.
DR   RefSeq; NP_052049.1; NC_001266.1.
DR   SMR; P25943; -.
DR   GeneID; 1486845; -.
DR   GeneID; 1487004; -.
DR   KEGG; vg:1486845; -.
DR   KEGG; vg:1487004; -.
DR   Proteomes; UP000000868; Genome.
DR   GO; GO:0005031; F:tumor necrosis factor receptor activity; IEA:InterPro.
DR   CDD; cd15839; TNFRSF_viral; 1.
DR   InterPro; IPR010806; Poxvirus_TNF-rcpt-II_C.
DR   InterPro; IPR011172; Poxvirus_TNF_rcpt-II.
DR   InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR   InterPro; IPR034059; TNFRSF_N_viral.
DR   Pfam; PF07190; DUF1406; 1.
DR   Pfam; PF00020; TNFR_c6; 2.
DR   PIRSF; PIRSF001790; TNF_C22L; 1.
DR   SMART; SM00208; TNFR; 3.
DR   PROSITE; PS00652; TNFR_NGFR_1; 2.
DR   PROSITE; PS50050; TNFR_NGFR_2; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Glycoprotein; Receptor; Reference proteome; Repeat; Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..325
FT                   /note="Tumor necrosis factor soluble receptor"
FT                   /id="PRO_0000034614"
FT   REPEAT          27..62
FT                   /note="TNFR-Cys 1"
FT   REPEAT          63..104
FT                   /note="TNFR-Cys 2"
FT   REPEAT          105..147
FT                   /note="TNFR-Cys 3"
FT   REPEAT          148..186
FT                   /note="TNFR-Cys 4"
FT   CARBOHYD        105
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        181
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        205
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        238
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   DISULFID        28..39
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        40..53
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        43..61
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        64..79
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        82..96
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        86..104
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        106..120
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        123..146
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        129..149
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        164..185
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
SQ   SEQUENCE   325 AA;  35132 MW;  810530339198A71E CRC64;
     MLRLIALLVC VVYVYGDDVP YSSNQGKCGG HDYEKDGLCC ASCHPGFYAS RLCGPGSNTV
     CSPCEDGTFT ASTNHAPACV SCRGPCTGHL SESQPCDRTH DRVCNCSTGN YCLLKGQNGC
     RICAPQTKCP AGYGVSGHTR AGDTLCEKCP PHTYSDSLSP TERCGTSFNY ISVGFNLYPV
     NETSCTTTAG HNEVIKTKEF TVTLNYTDCD PVFHTEYYAT SGKEGAGGFF TGTDIYQNTT
     KVCTLNVEIQ CSEGDDIHTL QKTNGGSTMP HSETITVVGS CLSDVNVDIM YSDTNHPGEV
     DDFVEYHWGT RLRFFPLPKR CTPVS