ID   VTA1_BOVIN              Reviewed;         307 AA.
AC   Q32L63;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Vacuolar protein sorting-associated protein VTA1 homolog;
GN   Name=VTA1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the endosomal multivesicular bodies (MVB)
CC       pathway. MVBs contain intraluminal vesicles (ILVs) that are generated
CC       by invagination and scission from the limiting membrane of the endosome
CC       and mostly are delivered to lysosomes enabling degradation of membrane
CC       proteins, such as stimulated growth factor receptors, lysosomal enzymes
CC       and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes
CC       disassembles membrane-associated ESCRT-III assemblies. Involved in the
CC       sorting and down-regulation of EGFR (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with VPS4B. Interacts with CHMP1B. Interacts with
CC       CHMP2A; the interaction probably involves the open conformation of
CC       (polymerized) CHMP2A. Interacts with CHMP3. Interacts with CHMP5; the
CC       interaction involves soluble CHMP5. Interacts with IST1 (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Endosome membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the VTA1 family. {ECO:0000305}.
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DR   EMBL; BC109746; AAI09747.1; -; mRNA.
DR   AlphaFoldDB; Q32L63; -.
DR   BMRB; Q32L63; -.
DR   SMR; Q32L63; -.
DR   STRING; 9913.ENSBTAP00000007693; -.
DR   PaxDb; Q32L63; -.
DR   PRIDE; Q32L63; -.
DR   eggNOG; KOG0917; Eukaryota.
DR   InParanoid; Q32L63; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032511; P:late endosome to vacuole transport via multivesicular body sorting pathway; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.270; -; 1.
DR   InterPro; IPR044538; Vta1-like.
DR   InterPro; IPR039431; Vta1/CALS_N.
DR   InterPro; IPR023175; Vta1/CALS_N_sf.
DR   InterPro; IPR041212; Vta1_C.
DR   PANTHER; PTHR46009; PTHR46009; 1.
DR   Pfam; PF04652; Vta1; 1.
DR   Pfam; PF18097; Vta1_C; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cytoplasm; Endosome; Membrane; Protein transport;
KW   Reference proteome; Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NP79"
FT   CHAIN           2..307
FT                   /note="Vacuolar protein sorting-associated protein VTA1
FT                   homolog"
FT                   /id="PRO_0000289142"
FT   REGION          2..187
FT                   /note="Interaction with IST1"
FT                   /evidence="ECO:0000250"
FT   REGION          2..75
FT                   /note="Interaction with CHMP5"
FT                   /evidence="ECO:0000250"
FT   REGION          180..240
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          198..307
FT                   /note="Interaction with VPS4B"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        186..213
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NP79"
SQ   SEQUENCE   307 AA;  34016 MW;  A6326EE80B0B2B6E CRC64;
     MAALATLPPL PPQFKSIQHH LRTAQEHDKR DPVVAYYCRL YAMQTGMKID SKTPECRKFL
     SRLMDQLEAL KKQLGDNEAI TQEIVGSAHL ENYALKMFLY ADNEDRAGRF HKNMIKSFYT
     ASLLIDVITV FGELTDENVK HRKYARWKAT YIHNCLKNGE TPQAGPVGIE EDNVDVEEYE
     DAGATSLPTQ PLQPSSSTYD PSNMPSSSYT GIQIPPGAHA PANTPAEVPH STGVTSNTIQ
     PTPQTIPAID PALFSTVSQG DIRLTPEDFA RAQKYCKYAG SALQYEDVST AVQNLQKALK
     LLTTGRE