VTA1_DICDI
ID VTA1_DICDI Reviewed; 550 AA.
AC Q55B11;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 75.
DE RecName: Full=Vacuolar protein sorting-associated protein VTA1 homolog;
GN Name=vta1; ORFNames=DDB_G0271488;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Involved in the endosomal multivesicular bodies (MVB)
CC pathway. MVBs contain intraluminal vesicles (ILVs) that are generated
CC by invagination and scission from the limiting membrane of the endosome
CC and are delivered to lysosomes enabling degradation of membrane
CC proteins. Thought to be a cofactor of VPS4, which catalyzes the
CC disassembly of membrane-associated ESCRT-III (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Endosome membrane
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the VTA1 family. {ECO:0000305}.
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DR EMBL; AAFI02000006; EAL71874.1; -; Genomic_DNA.
DR RefSeq; XP_645801.1; XM_640709.1.
DR AlphaFoldDB; Q55B11; -.
DR SMR; Q55B11; -.
DR STRING; 44689.DDB0234058; -.
DR PaxDb; Q55B11; -.
DR EnsemblProtists; EAL71874; EAL71874; DDB_G0271488.
DR GeneID; 8617993; -.
DR KEGG; ddi:DDB_G0271488; -.
DR dictyBase; DDB_G0271488; vta1.
DR eggNOG; KOG0917; Eukaryota.
DR HOGENOM; CLU_495612_0_0_1; -.
DR InParanoid; Q55B11; -.
DR OMA; KAGGNDQ; -.
DR Reactome; R-DDI-917729; Endosomal Sorting Complex Required For Transport (ESCRT).
DR PRO; PR:Q55B11; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005771; C:multivesicular body; IBA:GO_Central.
DR GO; GO:0032511; P:late endosome to vacuole transport via multivesicular body sorting pathway; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.270; -; 1.
DR InterPro; IPR044538; Vta1-like.
DR InterPro; IPR039431; Vta1/CALS_N.
DR InterPro; IPR023175; Vta1/CALS_N_sf.
DR InterPro; IPR041212; Vta1_C.
DR PANTHER; PTHR46009; PTHR46009; 2.
DR Pfam; PF04652; Vta1; 1.
DR Pfam; PF18097; Vta1_C; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Endosome; Membrane; Protein transport; Reference proteome;
KW Transport.
FT CHAIN 1..550
FT /note="Vacuolar protein sorting-associated protein VTA1
FT homolog"
FT /id="PRO_0000367443"
FT REGION 153..179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 220..460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 488..512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..272
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 280..349
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 370..393
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 425..460
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 488..509
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 550 AA; 61198 MW; AB4E180AC95C613F CRC64;
MDLASLPPAL KPIIPYLKQS QQLEKHDLLM AYYCRVHAIQ MAMDIKQKMG ASGSFLSIPI
VKILDQGDAD KAKLGSRLDE EDEAKYVEAF AMKAFSFADT QDRAGKANKA TSTTFYSAFL
FFNVLEHMGE VSEEVKLKKK YASWRSVDIN TAIKNGVAPS PPPSIDQNEE GGASGETEED
AQLKQLEMEL NLAKATLQQD NNNNNNMSSS TIITTNSVSE GMSSSLSFPS FPSIPNNNNN
NNNTTPSFPS FPSFPSPTNS DNNSNNNKPA FPSFPSFPSP PTTTNSDSAP SFPKFPSTPS
PTNSSSNNSQ QPSFPSFPSF TSPTNSNNNN NNSQQPSFPT FPNSTNQKRQ VFESDEEEEQ
EEVEDYSEKQ QQKSTSSSFP KFPSNSHNNE YNQPPPPAYE FKQSPPQQHK QSPPQQHHNS
HDNEALIKYQ QQVAQQNLTI QKQKHQNQML QDEVEQKQQQ IQLQQQQLQQ QQQQIQLLQK
QIQQQQKQLM SGGGGGGNMS MNLNHTPSDT DKASAEKYSK WVISSLQFDD VPSAVKNAKL
SLKYLTGEDS
