ID   VTA1_PONAB              Reviewed;         307 AA.
AC   Q5R5W5;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Vacuolar protein sorting-associated protein VTA1 homolog;
GN   Name=VTA1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the endosomal multivesicular bodies (MVB)
CC       pathway. MVBs contain intraluminal vesicles (ILVs) that are generated
CC       by invagination and scission from the limiting membrane of the endosome
CC       and mostly are delivered to lysosomes enabling degradation of membrane
CC       proteins, such as stimulated growth factor receptors, lysosomal enzymes
CC       and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes
CC       disassembles membrane-associated ESCRT-III assemblies. Involved in the
CC       sorting and down-regulation of EGFR (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with VPS4B. Interacts with CHMP1B. Interacts with
CC       CHMP2A; the interaction probably involves the open conformation of
CC       (polymerized) CHMP2A. Interacts with CHMP3. Interacts with CHMP5; the
CC       interaction involves soluble CHMP5. Interacts with IST1 (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Endosome membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the VTA1 family. {ECO:0000305}.
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DR   EMBL; CR860737; CAH92851.1; -; mRNA.
DR   RefSeq; NP_001126666.1; NM_001133194.1.
DR   AlphaFoldDB; Q5R5W5; -.
DR   BMRB; Q5R5W5; -.
DR   SMR; Q5R5W5; -.
DR   STRING; 9601.ENSPPYP00000019097; -.
DR   Ensembl; ENSPPYT00000019850; ENSPPYP00000019097; ENSPPYG00000017055.
DR   GeneID; 100173666; -.
DR   KEGG; pon:100173666; -.
DR   CTD; 51534; -.
DR   eggNOG; KOG0917; Eukaryota.
DR   GeneTree; ENSGT00390000011342; -.
DR   HOGENOM; CLU_030378_1_0_1; -.
DR   InParanoid; Q5R5W5; -.
DR   OMA; AYWCEYH; -.
DR   OrthoDB; 1450538at2759; -.
DR   TreeFam; TF105917; -.
DR   Proteomes; UP000001595; Chromosome 6.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0008022; F:protein C-terminus binding; IEA:Ensembl.
DR   GO; GO:0032511; P:late endosome to vacuole transport via multivesicular body sorting pathway; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0046755; P:viral budding; IEA:Ensembl.
DR   Gene3D; 1.25.40.270; -; 1.
DR   InterPro; IPR044538; Vta1-like.
DR   InterPro; IPR039431; Vta1/CALS_N.
DR   InterPro; IPR023175; Vta1/CALS_N_sf.
DR   InterPro; IPR041212; Vta1_C.
DR   PANTHER; PTHR46009; PTHR46009; 1.
DR   Pfam; PF04652; Vta1; 1.
DR   Pfam; PF18097; Vta1_C; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cytoplasm; Endosome; Membrane; Protein transport;
KW   Reference proteome; Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NP79"
FT   CHAIN           2..307
FT                   /note="Vacuolar protein sorting-associated protein VTA1
FT                   homolog"
FT                   /id="PRO_0000289143"
FT   REGION          2..186
FT                   /note="Interaction with IST1"
FT                   /evidence="ECO:0000250"
FT   REGION          2..75
FT                   /note="Interaction with CHMP5"
FT                   /evidence="ECO:0000250"
FT   REGION          160..233
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          198..307
FT                   /note="Interaction with VPS4B"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        184..210
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NP79"
SQ   SEQUENCE   307 AA;  33879 MW;  060E79BD5A9FB1CB CRC64;
     MAALAPLPPL PAQFKSIQHH LRTAQEHDKR DPVVAYYCRL YAMQTGMKID SKTPECRKFL
     SKLMDQLEAL KKQLGDNEAI TQEIVGCAHL ENYALKMFLY ADNEDRAGRF HKNMIKSFYT
     ASLLIDVITV FGELTDENVK HRKYARWKAT YIHNCLKNGE TPQAGPVGIE EDNDVEENED
     AGAASLPTQP TQPSSSSTYD PSNMPSGNYT GIQIPPGAHA PANTPAEVPH STGVASNTIQ
     PTPQTIPAID PALFNTISQG DIRLTPEDFA RAQKYCKYAG SALQYEDVST AVQNLQKALK
     LLTTGRE