ID   VTA1_SCHPO              Reviewed;         389 AA.
AC   O13703;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   18-APR-2012, sequence version 2.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Vacuolar protein sorting-associated protein vts1;
DE   AltName: Full=VPS20-associated protein 1;
GN   Name=vts1; Synonyms=new6; ORFNames=SPAC13F5.04c, SPAC13F5.08;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   REVISION OF GENE MODEL.
RX   PubMed=21511999; DOI=10.1126/science.1203357;
RA   Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA   Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA   Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA   Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA   French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA   Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA   Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA   Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA   Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA   Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT   "Comparative functional genomics of the fission yeasts.";
RL   Science 332:930-936(2011).
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=21270388; DOI=10.1534/genetics.110.123497;
RA   Bitton D.A., Wood V., Scutt P.J., Grallert A., Yates T., Smith D.L.,
RA   Hagan I.M., Miller C.J.;
RT   "Augmented annotation of the Schizosaccharomyces pombe genome reveals
RT   additional genes required for growth and viability.";
RL   Genetics 187:1207-1217(2011).
CC   -!- FUNCTION: Has a role in the formation of the multivesicular body (MVB).
CC       Required for the sorting of lipids to form intralumenal vesicles and
CC       for fluid-phase transport to the vacuole. Required for sorting several
CC       plasma membrane proteins into the MVB (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer (in cytoplasm). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q06263}.
CC       Endosome membrane {ECO:0000250|UniProtKB:Q06263}; Peripheral membrane
CC       protein {ECO:0000250|UniProtKB:Q06263}.
CC   -!- SIMILARITY: Belongs to the VTA1 family. {ECO:0000305}.
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DR   EMBL; CU329670; CAB11767.2; -; Genomic_DNA.
DR   PIR; T37629; T37629.
DR   RefSeq; NP_593652.2; NM_001019084.2.
DR   AlphaFoldDB; O13703; -.
DR   SMR; O13703; -.
DR   BioGRID; 279336; 9.
DR   STRING; 4896.SPAC13F5.04c.1; -.
DR   iPTMnet; O13703; -.
DR   MaxQB; O13703; -.
DR   PaxDb; O13703; -.
DR   PRIDE; O13703; -.
DR   EnsemblFungi; SPAC13F5.04c.1; SPAC13F5.04c.1:pep; SPAC13F5.04c.
DR   GeneID; 2542892; -.
DR   KEGG; spo:SPAC13F5.04c; -.
DR   PomBase; SPAC13F5.04c; -.
DR   VEuPathDB; FungiDB:SPAC13F5.04c; -.
DR   eggNOG; KOG0917; Eukaryota.
DR   HOGENOM; CLU_877604_0_0_1; -.
DR   InParanoid; O13703; -.
DR   OMA; AYWCEYH; -.
DR   Reactome; R-SPO-917729; Endosomal Sorting Complex Required For Transport (ESCRT).
DR   PRO; PR:O13703; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005771; C:multivesicular body; ISO:PomBase.
DR   GO; GO:0032511; P:late endosome to vacuole transport via multivesicular body sorting pathway; ISO:PomBase.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.270; -; 1.
DR   InterPro; IPR044538; Vta1-like.
DR   InterPro; IPR039431; Vta1/CALS_N.
DR   InterPro; IPR023175; Vta1/CALS_N_sf.
DR   InterPro; IPR041212; Vta1_C.
DR   PANTHER; PTHR46009; PTHR46009; 1.
DR   Pfam; PF04652; Vta1; 1.
DR   Pfam; PF18097; Vta1_C; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Endosome; Lipid transport; Membrane; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..389
FT                   /note="Vacuolar protein sorting-associated protein vts1"
FT                   /id="PRO_0000372360"
FT   REGION          149..335
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        151..335
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   389 AA;  42305 MW;  E807E2D5065EB384 CRC64;
     MIQIDTIPKE LQSIQPFVRR FNELEAHNPV IAYWSLYWAA QMALSSSHGV SNECKDFLLS
     LIEHLEDLRK NLGENENVSD ETSAKAYVES FSLEVLVQAE RNSKNGKPDV QAYLAARDFL
     ELSRIWGPPT EQITKSIKFC KLRALQVANP QRKAKTPSNH ATEELQQSST NSTTLPTQEA
     AVETNASASH ETSFALPTTS PAASLSISPT KSAAVSSEPN VEADVKSLSS TPAAPQLNSP
     SHSYEPTTFP STTSITENLP TIDPTRSTRS SSHIQSLSPE SKQTSDGHRP PSPTSITTTS
     TSIDPSVAFS SKSTLATTRT NAPLSRPSQP TKASPLNKFS ALEAIQSARS HARYAYSALD
     YEDTTTAIHH LKSALKLLEE EEQGNHTAD