ID   VTF3L_MONPZ             Reviewed;         382 AA.
AC   Q8V4V4;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   02-DEC-2020, entry version 45.
DE   RecName: Full=Intermediate transcription factor 3 large subunit;
DE   AltName: Full=VITF-3 45 kDa subunit;
GN   Name=VITF3L; ORFNames=A24R;
OS   Monkeypox virus (strain Zaire-96-I-16) (MPX).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=619591;
OH   NCBI_TaxID=45479; Cynomys gunnisoni (Gunnison's prairie dog).
OH   NCBI_TaxID=99825; Cynomys leucurus (White-tailed prairie dog).
OH   NCBI_TaxID=45480; Cynomys ludovicianus (Black-tailed prairie dog).
OH   NCBI_TaxID=99826; Cynomys mexicanus (Mexican prairie dog).
OH   NCBI_TaxID=99827; Cynomys parvidens (Utah prairie dog).
OH   NCBI_TaxID=30650; Gliridae (dormice).
OH   NCBI_TaxID=226685; Heliosciurus ruwenzorii (Ruwenzori sun squirrel).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=10090; Mus musculus (Mouse).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Zaire-96-I-16;
RX   PubMed=11734207; DOI=10.1016/s0014-5793(01)03144-1;
RA   Shchelkunov S.N., Totmenin A.V., Babkin I.V., Safronov P.F.,
RA   Ryazankina O.I., Petrov N.A., Gutorov V.V., Uvarova E.A., Mikheev M.V.,
RA   Sisler J.R., Esposito J.J., Jahrling P.B., Moss B., Sandakhchiev L.S.;
RT   "Human monkeypox and smallpox viruses: genomic comparison.";
RL   FEBS Lett. 509:66-70(2001).
CC   -!- FUNCTION: Acts with RNA polymerase to initiate transcription from
CC       intermediate gene promoters. {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of a 45 kDa and a 32 kDa subunit. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the poxviruses A23 family. {ECO:0000305}.
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DR   EMBL; AF380138; AAL40592.1; -; Genomic_DNA.
DR   RefSeq; NP_536561.1; NC_003310.1.
DR   GeneID; 928978; -.
DR   KEGG; vg:928978; -.
DR   Proteomes; UP000101269; Genome.
DR   InterPro; IPR008789; Poxvirus_intermed-TF.
DR   Pfam; PF05718; Pox_int_trans; 1.
PE   3: Inferred from homology;
KW   Activator; Transcription; Transcription regulation.
FT   CHAIN           1..382
FT                   /note="Intermediate transcription factor 3 large subunit"
FT                   /id="PRO_0000099188"
SQ   SEQUENCE   382 AA;  44523 MW;  311C37A271E87353 CRC64;
     MDNLFTFLHE IEDRYARTIF NFHLISCDEI GDIYGLMKER ISSEDMFDNI VYNKDIHPAI
     KKLVYCDIQL TKHIINQNTY PVFNDSSQVK CCHYFDINSD NSNISSRTVE IFESEKSSLV
     SYIKTTNKKR KVNYGEIKKT VHGGTNANYF SGKKSDEYLS TTVRSNINQP WIKTISKRMR
     VDIINHSIVT RGKSSILQTI EIIFTNRTCV KIFKDSTMHI ILSKDKDEKG CINMIDKLFY
     VYYNLFLLFE DIIQNEYFKE VANVVNHVLM ATALDEKLFL IKKMAEHDVY GVSNFKIGMF
     NLTFIKSLDH TVFPSLLDED SKIKFFKGKK LNIVALRSLE DCTNYVTKSE NMIEMMKERS
     TILNSIDIET ESVDRLKELL LK