ID   VTF3S_VAR67             Reviewed;         288 AA.
AC   P0DSP9; P33834;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2019, sequence version 1.
DT   23-FEB-2022, entry version 6.
DE   RecName: Full=Intermediate transcription factor 3 small subunit;
DE   AltName: Full=VITF-3 32 kDa subunit;
DE   AltName: Full=VITF-3 small subunit;
GN   Name=VITF3S; ORFNames=A8R;
OS   Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=587200;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1666548;
RA   Shchelkunov S.N., Marennikova S.S., Totmenin A.V., Blinov V.M.,
RA   Chizhikov V.E., Gutorov V.V., Safronov P.F., Pozdnyakov S.G.,
RA   Shelukhina E.M., Gashnikov P.V., Anjaparidze O.G., Sandakhchiev L.S.;
RT   "Creation of a clone library of fragments from the natural variola virus
RT   and study of the structural and functional organization of viral genes from
RT   a circle of hosts.";
RL   Dokl. Akad. Nauk SSSR 321:402-406(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8384129; DOI=10.1016/0014-5793(93)80041-r;
RA   Shchelkunov S.N., Blinov V.M., Sandakhchiev L.S.;
RT   "Genes of variola and vaccinia viruses necessary to overcome the host
RT   protective mechanisms.";
RL   FEBS Lett. 319:80-83(1993).
CC   -!- FUNCTION: Acts with RNA polymerase to initiate transcription from
CC       intermediate gene promoters. {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of a 45 kDa (A23R) and a 32 kDa (A8R) subunit to
CC       form the virus intermediate transcription factor (VITF)-3.
CC       {ECO:0000250}.
CC   -!- INDUCTION: Expressed in the early phase of the viral replicative cycle.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae A8 family. {ECO:0000305}.
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DR   EMBL; X69198; CAA49053.1; -; Genomic_DNA.
DR   EMBL; X67116; CAA47519.1; -; Genomic_DNA.
DR   PIR; I36848; I36848.
DR   RefSeq; NP_042156.1; NC_001611.1.
DR   GeneID; 1486538; -.
DR   KEGG; vg:1486538; -.
DR   Proteomes; UP000002060; Genome.
DR   InterPro; IPR006834; Pox_A8.
DR   Pfam; PF04745; Pox_A8; 1.
PE   2: Evidence at transcript level;
KW   Activator; Early protein; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..288
FT                   /note="Intermediate transcription factor 3 small subunit"
FT                   /id="PRO_0000099193"
SQ   SEQUENCE   288 AA;  33554 MW;  A2C2F80F45149935 CRC64;
     MFEPVPDLNL EASVELGEVN IDQTTPMIKE NIGFISRSRR LFAHRSKDDE RKLALRFFLQ
     RLYFLDHREI HYLFRCVDAV KDVTITKKNN IIVAPYIALL TIASKGCKLT ETMIEAFFPE
     LYNEHSKKFK FNSQVSIIQE KLGYQSGNYH VYDFEPYYST VALAIRDEHS SGIFNIRQES
     YLVSSLSEIT YRFYLINLKS DLVQWSASTG AVINQMVNTV LITVYEKLQL VIENDSQFIC
     SLAVESELPI KLLKDRNELF TKFINELKKT SSFKISKRDK DTLLKYFT