ID   VTF3S_VARV              Reviewed;         288 AA.
AC   P0DSQ0; P33834;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2019, sequence version 1.
DT   23-FEB-2022, entry version 11.
DE   RecName: Full=Intermediate transcription factor 3 small subunit;
DE   AltName: Full=VITF-3 32 kDa subunit;
DE   AltName: Full=VITF-3 small subunit;
GN   Name=VITF3S; ORFNames=A8R;
OS   Variola virus.
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=10255;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Bangladesh-1975;
RX   PubMed=8264798; DOI=10.1038/366748a0;
RA   Massung R.F., Esposito J.J., Liu L.I., Qi J., Utterback T.R., Knight J.C.,
RA   Aubin L., Yuran T.E., Parsons J.M., Loparev V.N., Selivanov N.A.,
RA   Cavallaro K.F., Kerlavage A.R., Mahy B.W.J., Venter J.C.;
RT   "Potential virulence determinants in terminal regions of variola smallpox
RT   virus genome.";
RL   Nature 366:748-751(1993).
CC   -!- FUNCTION: Acts with RNA polymerase to initiate transcription from
CC       intermediate gene promoters. {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of a 45 kDa (A23R) and a 32 kDa (A8R) subunit to
CC       form the virus intermediate transcription factor (VITF)-3.
CC       {ECO:0000250}.
CC   -!- INDUCTION: Expressed in the early phase of the viral replicative cycle.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae A8 family. {ECO:0000305}.
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DR   EMBL; L22579; AAA60860.1; -; Genomic_DNA.
DR   PIR; T28550; T28550.
DR   RefSeq; NP_042156.1; NC_001611.1.
DR   GeneID; 1486538; -.
DR   KEGG; vg:1486538; -.
DR   Proteomes; UP000119805; Genome.
DR   InterPro; IPR006834; Pox_A8.
DR   Pfam; PF04745; Pox_A8; 1.
PE   2: Evidence at transcript level;
KW   Activator; Early protein; Transcription; Transcription regulation.
FT   CHAIN           1..288
FT                   /note="Intermediate transcription factor 3 small subunit"
FT                   /id="PRO_0000448140"
SQ   SEQUENCE   288 AA;  33554 MW;  A2C2F80F45149935 CRC64;
     MFEPVPDLNL EASVELGEVN IDQTTPMIKE NIGFISRSRR LFAHRSKDDE RKLALRFFLQ
     RLYFLDHREI HYLFRCVDAV KDVTITKKNN IIVAPYIALL TIASKGCKLT ETMIEAFFPE
     LYNEHSKKFK FNSQVSIIQE KLGYQSGNYH VYDFEPYYST VALAIRDEHS SGIFNIRQES
     YLVSSLSEIT YRFYLINLKS DLVQWSASTG AVINQMVNTV LITVYEKLQL VIENDSQFIC
     SLAVESELPI KLLKDRNELF TKFINELKKT SSFKISKRDK DTLLKYFT