VTI1B_BOVIN
ID VTI1B_BOVIN Reviewed; 232 AA.
AC Q2KIU0;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 07-MAR-2006, sequence version 1.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=Vesicle transport through interaction with t-SNAREs homolog 1B;
GN Name=VTI1B;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Testis;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: V-SNARE that mediates vesicle transport pathways through
CC interactions with t-SNAREs on the target membrane. These interactions
CC are proposed to mediate aspects of the specificity of vesicle
CC trafficking and to promote fusion of the lipid bilayers. May be
CC concerned with increased secretion of cytokines associated with
CC cellular senescence. {ECO:0000250|UniProtKB:Q9UEU0}.
CC -!- SUBUNIT: Forms a SNARE complex with STX7, STX8 and VAMP8 which
CC functions in the homotypic fusion of late endosomes. Component of the
CC SNARE complex composed of STX7, STX8, VAMP7 and VIT1B that is required
CC for heterotypic fusion of late endosomes with lysosomes (By
CC similarity). May interact with STX17. Interacts with CLINT1 (By
CC similarity). {ECO:0000250|UniProtKB:O88384,
CC ECO:0000250|UniProtKB:Q9UEU0}.
CC -!- SUBCELLULAR LOCATION: Early endosome membrane
CC {ECO:0000250|UniProtKB:Q9UEU0}; Single-pass type IV membrane protein
CC {ECO:0000255}. Late endosome membrane {ECO:0000250|UniProtKB:Q9UEU0};
CC Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q9UEU0}.
CC Lysosome membrane {ECO:0000250|UniProtKB:Q9UEU0}. Cytoplasmic granule
CC {ECO:0000250|UniProtKB:Q9UEU0}. Recycling endosome membrane
CC {ECO:0000250|UniProtKB:Q9UEU0}; Single-pass type IV membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the VTI1 family. {ECO:0000305}.
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DR EMBL; BC112511; AAI12512.1; -; mRNA.
DR RefSeq; NP_001073115.1; NM_001079647.2.
DR AlphaFoldDB; Q2KIU0; -.
DR SMR; Q2KIU0; -.
DR STRING; 9913.ENSBTAP00000002532; -.
DR PaxDb; Q2KIU0; -.
DR PRIDE; Q2KIU0; -.
DR GeneID; 780809; -.
DR KEGG; bta:780809; -.
DR CTD; 10490; -.
DR eggNOG; KOG1666; Eukaryota.
DR InParanoid; Q2KIU0; -.
DR OrthoDB; 1195966at2759; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031902; C:late endosome membrane; ISS:UniProtKB.
DR GO; GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
DR GO; GO:0055038; C:recycling endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031201; C:SNARE complex; IBA:GO_Central.
DR GO; GO:0005484; F:SNAP receptor activity; IBA:GO_Central.
DR GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR GO; GO:0006896; P:Golgi to vacuole transport; IBA:GO_Central.
DR GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0016236; P:macroautophagy; IBA:GO_Central.
DR GO; GO:1903076; P:regulation of protein localization to plasma membrane; IBA:GO_Central.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IBA:GO_Central.
DR GO; GO:0006906; P:vesicle fusion; IBA:GO_Central.
DR GO; GO:0048280; P:vesicle fusion with Golgi apparatus; IBA:GO_Central.
DR Gene3D; 1.20.58.400; -; 1.
DR InterPro; IPR010989; SNARE.
DR InterPro; IPR000727; T_SNARE_dom.
DR InterPro; IPR038407; v-SNARE_N_sf.
DR InterPro; IPR007705; Vesicle_trsprt_v-SNARE_N.
DR Pfam; PF05008; V-SNARE; 1.
DR SMART; SM00397; t_SNARE; 1.
DR SUPFAM; SSF47661; SSF47661; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Coiled coil; Endosome; Lysosome; Membrane; Methylation;
KW Phosphoprotein; Protein transport; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q9UEU0"
FT CHAIN 2..232
FT /note="Vesicle transport through interaction with t-SNAREs
FT homolog 1B"
FT /id="PRO_0000285575"
FT TOPO_DOM 2..208
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 209..229
FT /note="Helical; Anchor for type IV membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 230..232
FT /note="Vesicular"
FT /evidence="ECO:0000255"
FT REGION 2..23
FT /note="Interaction with CLINT1"
FT /evidence="ECO:0000250|UniProtKB:Q9UEU0"
FT REGION 69..73
FT /note="Interaction with CLINT1"
FT /evidence="ECO:0000250|UniProtKB:Q9UEU0"
FT COILED 35..98
FT /evidence="ECO:0000255"
FT COILED 161..198
FT /evidence="ECO:0000255"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q9UEU0"
FT MOD_RES 103
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9UEU0"
FT MOD_RES 107
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q9UEU0"
FT MOD_RES 138
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UEU0"
SQ SEQUENCE 232 AA; 26709 MW; 5652AEF15BCB5C47 CRC64;
MATSAASSEH FEKLHEIFRG LHEDLRGVPE RLLGMAGTEE KKKLIRDFDE KQQEANETLA
EMEEELRYAP LSFRNPMMSK LRTYRKDLAK LHREVRSTPL TATPGARGDM KYGTYAVENE
HMNRLQSQRA LLLQGTDSLN RATQSIERSH RIAAETDQIG SEIIEELGEQ RDQLERTKSR
LVNTSENLSK SRKILRSMSR KVTTNKLLLS IVILLELAIL GGLVYYKFLR RH
