VTI1_SCHPO
ID VTI1_SCHPO Reviewed; 214 AA.
AC P78768; O43039;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2001, sequence version 2.
DT 25-MAY-2022, entry version 143.
DE RecName: Full=Vesicle transport v-SNARE protein vti1;
GN Name=vti1; ORFNames=SPBC3B9.10;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=PR745;
RX PubMed=9501991; DOI=10.1093/dnares/4.6.363;
RA Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.;
RT "Identification of open reading frames in Schizosaccharomyces pombe
RT cDNAs.";
RL DNA Res. 4:363-369(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: V-SNARE that mediates vesicle transport pathways through
CC interactions with t-SNAREs on the target membrane. These interactions
CC are proposed to mediate aspects of the specificity of vesicle
CC trafficking and to promote fusion of the lipid bilayers (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type IV
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the VTI1 family. {ECO:0000305}.
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DR EMBL; D89116; BAA13778.1; -; mRNA.
DR EMBL; CU329671; CAA17790.1; -; Genomic_DNA.
DR PIR; T40349; T40349.
DR PIR; T42225; T42225.
DR RefSeq; NP_596668.1; NM_001022590.2.
DR AlphaFoldDB; P78768; -.
DR SMR; P78768; -.
DR BioGRID; 277486; 3.
DR STRING; 4896.SPBC3B9.10.1; -.
DR iPTMnet; P78768; -.
DR MaxQB; P78768; -.
DR PaxDb; P78768; -.
DR PRIDE; P78768; -.
DR EnsemblFungi; SPBC3B9.10.1; SPBC3B9.10.1:pep; SPBC3B9.10.
DR GeneID; 2540970; -.
DR KEGG; spo:SPBC3B9.10; -.
DR PomBase; SPBC3B9.10; vti1.
DR VEuPathDB; FungiDB:SPBC3B9.10; -.
DR eggNOG; KOG1666; Eukaryota.
DR HOGENOM; CLU_075474_0_1_1; -.
DR InParanoid; P78768; -.
DR OMA; RGRVESH; -.
DR PhylomeDB; P78768; -.
DR Reactome; R-SPO-114608; Platelet degranulation.
DR Reactome; R-SPO-6811440; Retrograde transport at the Trans-Golgi-Network.
DR PRO; PR:P78768; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; IBA:GO_Central.
DR GO; GO:0000324; C:fungal-type vacuole; HDA:PomBase.
DR GO; GO:0005794; C:Golgi apparatus; HDA:PomBase.
DR GO; GO:0030173; C:integral component of Golgi membrane; ISO:PomBase.
DR GO; GO:0031902; C:late endosome membrane; IBA:GO_Central.
DR GO; GO:0031201; C:SNARE complex; IBA:GO_Central.
DR GO; GO:0005774; C:vacuolar membrane; IDA:PomBase.
DR GO; GO:0005484; F:SNAP receptor activity; ISO:PomBase.
DR GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR GO; GO:0006896; P:Golgi to vacuole transport; ISO:PomBase.
DR GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; ISO:PomBase.
DR GO; GO:0006886; P:intracellular protein transport; NAS:PomBase.
DR GO; GO:0045324; P:late endosome to vacuole transport; ISO:PomBase.
DR GO; GO:0016236; P:macroautophagy; IBA:GO_Central.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IBA:GO_Central.
DR GO; GO:0048278; P:vesicle docking; IC:PomBase.
DR GO; GO:0006906; P:vesicle fusion; IBA:GO_Central.
DR GO; GO:0048280; P:vesicle fusion with Golgi apparatus; IBA:GO_Central.
DR Gene3D; 1.20.58.400; -; 1.
DR InterPro; IPR010989; SNARE.
DR InterPro; IPR000727; T_SNARE_dom.
DR InterPro; IPR038407; v-SNARE_N_sf.
DR InterPro; IPR007705; Vesicle_trsprt_v-SNARE_N.
DR Pfam; PF05008; V-SNARE; 1.
DR SMART; SM00397; t_SNARE; 1.
DR SUPFAM; SSF47661; SSF47661; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Membrane; Protein transport; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..214
FT /note="Vesicle transport v-SNARE protein vti1"
FT /id="PRO_0000218231"
FT TOPO_DOM 1..191
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 192..212
FT /note="Helical; Anchor for type IV membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 213..214
FT /note="Vesicular"
FT /evidence="ECO:0000255"
FT CONFLICT 135
FT /note="Q -> H (in Ref. 1; BAA13778)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 214 AA; 24743 MW; 641A57E4D7E52A6F CRC64;
METYEQEYRL LRADIEEKLN DLSKSGENSV IQSCQRLLNE IDEVIGQMEI EITGIPTSER
GLVNGRIRSY RSTLEEWRRH LKEEIGKSDR KALFGNRDET SGDYIASDQD YDQRTRLLQG
TNRLEQSSQR LLESQRIANE TEGIGASILR DLHGQRNQLE HSLEMLGDTS GHLDRSLRTL
KTMARRLAMN RFFTTAIIAI LVILILLVLY SKFR
