ID   VTM2B_HUMAN             Reviewed;         285 AA.
AC   A6NLU5;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 2.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=V-set and transmembrane domain-containing protein 2B;
DE   Flags: Precursor;
GN   Name=VSTM2B;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
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DR   EMBL; AC011474; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS46034.1; -.
DR   RefSeq; NP_001139811.1; NM_001146339.1.
DR   RefSeq; XP_011525204.1; XM_011526902.2.
DR   AlphaFoldDB; A6NLU5; -.
DR   BioGRID; 131201; 1.
DR   IntAct; A6NLU5; 1.
DR   STRING; 9606.ENSP00000335038; -.
DR   iPTMnet; A6NLU5; -.
DR   PhosphoSitePlus; A6NLU5; -.
DR   BioMuta; VSTM2B; -.
DR   MassIVE; A6NLU5; -.
DR   PaxDb; A6NLU5; -.
DR   PeptideAtlas; A6NLU5; -.
DR   PRIDE; A6NLU5; -.
DR   ProteomicsDB; 1493; -.
DR   Antibodypedia; 76668; 6 antibodies from 2 providers.
DR   DNASU; 342865; -.
DR   Ensembl; ENST00000335523.8; ENSP00000335038.6; ENSG00000187135.8.
DR   GeneID; 342865; -.
DR   KEGG; hsa:342865; -.
DR   MANE-Select; ENST00000335523.8; ENSP00000335038.6; NM_001146339.2; NP_001139811.1.
DR   UCSC; uc010xrl.2; human.
DR   CTD; 342865; -.
DR   GeneCards; VSTM2B; -.
DR   HGNC; HGNC:33595; VSTM2B.
DR   HPA; ENSG00000187135; Tissue enriched (brain).
DR   neXtProt; NX_A6NLU5; -.
DR   OpenTargets; ENSG00000187135; -.
DR   PharmGKB; PA162408890; -.
DR   VEuPathDB; HostDB:ENSG00000187135; -.
DR   eggNOG; ENOG502QSS5; Eukaryota.
DR   GeneTree; ENSGT00940000161356; -.
DR   HOGENOM; CLU_081009_0_0_1; -.
DR   InParanoid; A6NLU5; -.
DR   OMA; NRAKVAH; -.
DR   OrthoDB; 1216208at2759; -.
DR   PhylomeDB; A6NLU5; -.
DR   TreeFam; TF331739; -.
DR   PathwayCommons; A6NLU5; -.
DR   SignaLink; A6NLU5; -.
DR   BioGRID-ORCS; 342865; 13 hits in 1058 CRISPR screens.
DR   GenomeRNAi; 342865; -.
DR   Pharos; A6NLU5; Tdark.
DR   PRO; PR:A6NLU5; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; A6NLU5; protein.
DR   Bgee; ENSG00000187135; Expressed in Brodmann (1909) area 9 and 53 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Immunoglobulin domain; Membrane; Reference proteome;
KW   Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..285
FT                   /note="V-set and transmembrane domain-containing protein
FT                   2B"
FT                   /id="PRO_0000319943"
FT   TOPO_DOM        29..263
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        264..284
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        285
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          29..143
FT                   /note="Ig-like V-type"
FT   REGION          161..226
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        182..196
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        49..127
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   285 AA;  30297 MW;  B21B2FF41E3DC320 CRC64;
     MEQRNRLGAL GYLPPLLLHA LLLFVADAAF TEVPKDVTVR EGDDIEMPCA FRASGATSYS
     LEIQWWYLKE PPRELLHELA LSVPGARSKV TNKDATKIST VRVQGNDISH RLRLSAVRLQ
     DEGVYECRVS DYSDDDTQEH KAQAMLRVLS RFAPPNMQAA EAVSHIQSSG PRRHGPASAA
     NANNAGAASR TTSEPGRGDK SPPPGSPPAA IDPAVPEAAA ASAAHTPTTT VAAAAAASSA
     SPPSGQAVLL RQRHGSGTGR SYTTDPLLSL LLLALHKFLR LLLGH