VTM2B_MOUSE
ID VTM2B_MOUSE Reviewed; 285 AA.
AC Q9JME9; Q8CEK5;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=V-set and transmembrane domain-containing protein 2B;
DE Flags: Precursor;
GN Name=Vstm2b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=10679242; DOI=10.1006/bbrc.2000.2170;
RA Inoue S., Sano H., Ohta M.;
RT "Growth suppression of Escherichia coli by induction of expression of
RT mammalian genes with transmembrane or ATPase domains.";
RL Biochem. Biophys. Res. Commun. 268:553-561(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 165-285.
RC STRAIN=C57BL/6J; TISSUE=Diencephalon;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
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DR EMBL; AB030198; BAA92761.1; -; mRNA.
DR EMBL; AK020370; BAC25628.1; -; mRNA.
DR CCDS; CCDS21160.1; -.
DR RefSeq; NP_067362.1; NM_021387.3.
DR AlphaFoldDB; Q9JME9; -.
DR SMR; Q9JME9; -.
DR STRING; 10090.ENSMUSP00000044002; -.
DR PhosphoSitePlus; Q9JME9; -.
DR PaxDb; Q9JME9; -.
DR PeptideAtlas; Q9JME9; -.
DR PRIDE; Q9JME9; -.
DR ProteomicsDB; 297828; -.
DR Antibodypedia; 76668; 6 antibodies from 2 providers.
DR DNASU; 58188; -.
DR Ensembl; ENSMUST00000044705; ENSMUSP00000044002; ENSMUSG00000039257.
DR Ensembl; ENSMUST00000205845; ENSMUSP00000146231; ENSMUSG00000039257.
DR GeneID; 58188; -.
DR KEGG; mmu:58188; -.
DR UCSC; uc009glh.1; mouse.
DR CTD; 342865; -.
DR MGI; MGI:1914525; Vstm2b.
DR VEuPathDB; HostDB:ENSMUSG00000039257; -.
DR eggNOG; ENOG502QSS5; Eukaryota.
DR GeneTree; ENSGT00940000161356; -.
DR HOGENOM; CLU_081009_0_0_1; -.
DR InParanoid; Q9JME9; -.
DR OMA; NRAKVAH; -.
DR OrthoDB; 1216208at2759; -.
DR PhylomeDB; Q9JME9; -.
DR TreeFam; TF331739; -.
DR BioGRID-ORCS; 58188; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Vstm2b; mouse.
DR PRO; PR:Q9JME9; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q9JME9; protein.
DR Bgee; ENSMUSG00000039257; Expressed in pyloric antrum and 146 other tissues.
DR ExpressionAtlas; Q9JME9; baseline and differential.
DR Genevisible; Q9JME9; MM.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Immunoglobulin domain; Membrane; Reference proteome;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..28
FT /evidence="ECO:0000255"
FT CHAIN 29..285
FT /note="V-set and transmembrane domain-containing protein
FT 2B"
FT /id="PRO_0000319944"
FT TOPO_DOM 29..263
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 264..284
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 285
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 29..143
FT /note="Ig-like V-type"
FT REGION 160..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..192
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 49..127
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT CONFLICT 165
FT /note="H -> D (in Ref. 2; BAC25628)"
FT /evidence="ECO:0000305"
FT CONFLICT 267
FT /note="L -> Q (in Ref. 2; BAC25628)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 285 AA; 30160 MW; 1CED2C02E2C83BF1 CRC64;
MEQRNRLGAL GYLLPLLLHS LLLFVADATF TEVPKDVTVR EGDDIEMPCA FRASGATSYS
LEIQWWYLKE PPRELLHELA LSVPGARSKV TNKDATKIST VRVQGNDISH RLRLSAVRLQ
DEGVYECRVS DYSDDDTQEH KAQALLRVLS RFAPPNMQAA EAVSHIQSSG PRRHGASSAV
SSNNAGAAVR TTSETSHDDK NPPPGSPPAG SGVPEAAAAA ASATHTATTT AAAAAASSSA
SPPSGQAVLL RQRHGSGTGP GYSADPLLSL LLLALHKFLH PLLGH
