ID   VTM2B_XENTR             Reviewed;         251 AA.
AC   Q0IJ12;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=V-set and transmembrane domain-containing protein 2B;
DE   Flags: Precursor;
GN   Name=vstm2b;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
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DR   EMBL; BC121271; AAI21272.1; -; mRNA.
DR   RefSeq; NP_001072789.1; NM_001079321.1.
DR   AlphaFoldDB; Q0IJ12; -.
DR   SMR; Q0IJ12; -.
DR   STRING; 8364.ENSXETP00000062844; -.
DR   PaxDb; Q0IJ12; -.
DR   PRIDE; Q0IJ12; -.
DR   DNASU; 780250; -.
DR   GeneID; 780250; -.
DR   KEGG; xtr:780250; -.
DR   CTD; 342865; -.
DR   Xenbase; XB-GENE-947810; vstm2b.
DR   eggNOG; ENOG502QSS5; Eukaryota.
DR   HOGENOM; CLU_081009_0_0_1; -.
DR   InParanoid; Q0IJ12; -.
DR   OMA; NRAKVAH; -.
DR   OrthoDB; 1216208at2759; -.
DR   TreeFam; TF331739; -.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Immunoglobulin domain; Membrane; Reference proteome;
KW   Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..251
FT                   /note="V-set and transmembrane domain-containing protein
FT                   2B"
FT                   /id="PRO_0000319945"
FT   TOPO_DOM        26..226
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        227..247
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        248..251
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          26..142
FT                   /note="Ig-like V-type"
FT   REGION          157..213
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        160..180
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        46..125
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   251 AA;  27548 MW;  E7542E85ACC6AAF3 CRC64;
     MEKQGLFSAL CYLMLNTPLL FSVNATFTEV PKDVTIREGE DIEMPCAFRA SGSTSFSLEI
     QWWYLKEATR EMAQELAISA PGNRNKVTTS KDATKISTVR VQGNDISHRL RLSNVKKQDE
     GVYECRVSDF GDDETQEHKA QAMLRVISRF SPPDMQAAEA VSHIQSSGPR RNNPSSRATP
     EPGNKRAVPP AENLAPSLST AASSSASPAP GKAAILRQQH GSGTGPIFAN DPALYMFLLI
     FHQLVYLLLN H