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VTM2L_HUMAN
ID   VTM2L_HUMAN             Reviewed;         204 AA.
AC   Q96N03; E1P5V7; Q5JWZ4; Q5JWZ5; Q8ND45; Q9BR37;
DT   13-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 160.
DE   RecName: Full=V-set and transmembrane domain-containing protein 2-like protein;
DE   Flags: Precursor;
GN   Name=VSTM2L; Synonyms=C20orf102;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Brain;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11780052; DOI=10.1038/414865a;
RA   Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA   Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA   Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA   Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA   Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA   Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA   Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA   Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA   Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA   Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA   Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA   Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA   Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA   Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA   Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA   Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA   Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA   Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA   Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA   Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA   Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 20.";
RL   Nature 414:865-871(2001).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q96N03; P54253: ATXN1; NbExp=9; IntAct=EBI-948213, EBI-930964;
CC       Q96N03; Q9BSQ5: CCM2; NbExp=3; IntAct=EBI-948213, EBI-1573056;
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q96N03-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q96N03-2; Sequence=VSP_013380, VSP_026514;
CC       Name=3;
CC         IsoId=Q96N03-3; Sequence=VSP_026512, VSP_026513;
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DR   EMBL; AK056177; BAB71113.1; -; mRNA.
DR   EMBL; AL834410; CAD39072.2; -; mRNA.
DR   EMBL; AL109964; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471077; EAW76051.1; -; Genomic_DNA.
DR   EMBL; CH471077; EAW76053.1; -; Genomic_DNA.
DR   EMBL; BC033818; AAH33818.1; -; mRNA.
DR   CCDS; CCDS13299.1; -. [Q96N03-1]
DR   RefSeq; NP_542174.1; NM_080607.2. [Q96N03-1]
DR   AlphaFoldDB; Q96N03; -.
DR   BioGRID; 126121; 5.
DR   IntAct; Q96N03; 2.
DR   STRING; 9606.ENSP00000362560; -.
DR   iPTMnet; Q96N03; -.
DR   PhosphoSitePlus; Q96N03; -.
DR   BioMuta; VSTM2L; -.
DR   DMDM; 27151481; -.
DR   EPD; Q96N03; -.
DR   jPOST; Q96N03; -.
DR   MassIVE; Q96N03; -.
DR   MaxQB; Q96N03; -.
DR   PaxDb; Q96N03; -.
DR   PeptideAtlas; Q96N03; -.
DR   PRIDE; Q96N03; -.
DR   ProteomicsDB; 77436; -. [Q96N03-1]
DR   ProteomicsDB; 77437; -. [Q96N03-2]
DR   Antibodypedia; 26791; 50 antibodies from 17 providers.
DR   DNASU; 128434; -.
DR   Ensembl; ENST00000373459.4; ENSP00000362558.4; ENSG00000132821.12. [Q96N03-3]
DR   Ensembl; ENST00000373461.9; ENSP00000362560.4; ENSG00000132821.12. [Q96N03-1]
DR   Ensembl; ENST00000448944.1; ENSP00000406537.1; ENSG00000132821.12. [Q96N03-2]
DR   GeneID; 128434; -.
DR   KEGG; hsa:128434; -.
DR   MANE-Select; ENST00000373461.9; ENSP00000362560.4; NM_080607.3; NP_542174.1.
DR   UCSC; uc002xhk.5; human. [Q96N03-1]
DR   CTD; 128434; -.
DR   DisGeNET; 128434; -.
DR   GeneCards; VSTM2L; -.
DR   HGNC; HGNC:16096; VSTM2L.
DR   HPA; ENSG00000132821; Tissue enhanced (brain, heart muscle).
DR   neXtProt; NX_Q96N03; -.
DR   OpenTargets; ENSG00000132821; -.
DR   PharmGKB; PA162408904; -.
DR   VEuPathDB; HostDB:ENSG00000132821; -.
DR   eggNOG; ENOG502RY0S; Eukaryota.
DR   GeneTree; ENSGT00940000159381; -.
DR   HOGENOM; CLU_1916373_0_0_1; -.
DR   InParanoid; Q96N03; -.
DR   OMA; NDCSNEP; -.
DR   OrthoDB; 1216208at2759; -.
DR   PhylomeDB; Q96N03; -.
DR   TreeFam; TF331739; -.
DR   PathwayCommons; Q96N03; -.
DR   SignaLink; Q96N03; -.
DR   BioGRID-ORCS; 128434; 16 hits in 1069 CRISPR screens.
DR   ChiTaRS; VSTM2L; human.
DR   GenomeRNAi; 128434; -.
DR   Pharos; Q96N03; Tdark.
DR   PRO; PR:Q96N03; -.
DR   Proteomes; UP000005640; Chromosome 20.
DR   RNAct; Q96N03; protein.
DR   Bgee; ENSG00000132821; Expressed in right atrium auricular region and 132 other tissues.
DR   Genevisible; Q96N03; HS.
DR   GO; GO:0030424; C:axon; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0098632; F:cell-cell adhesion mediator activity; IBA:GO_Central.
DR   GO; GO:0007411; P:axon guidance; IBA:GO_Central.
DR   GO; GO:0070593; P:dendrite self-avoidance; IBA:GO_Central.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IBA:GO_Central.
DR   GO; GO:0043524; P:negative regulation of neuron apoptotic process; IDA:UniProtKB.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   InterPro; IPR027115; VSTM2L.
DR   PANTHER; PTHR12207:SF29; PTHR12207:SF29; 1.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Disulfide bond; Immunoglobulin domain;
KW   Reference proteome; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..204
FT                   /note="V-set and transmembrane domain-containing protein 2-
FT                   like protein"
FT                   /id="PRO_0000015164"
FT   DOMAIN          41..158
FT                   /note="Ig-like"
FT   REGION          168..204
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        62..142
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   VAR_SEQ         41..132
FT                   /note="ALFTETPHDMTARTGEDVEMACSFRGSGSPSYSLEIQWWYVRSHRDWTDKQA
FT                   WASNQLKASQQEDAGKEATKISVVKVVGSNISHKLRLSRV -> GGQGGGQQHLPQAAP
FT                   VPGEAHGRRHLRVPRHRLQRRQGPAPQGQGLPAGAARGELRPASARSPSRRARPAAPQA
FT                   RQGAEEALGGPGGLQPLD (in isoform 3)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_026512"
FT   VAR_SEQ         98..114
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_013380"
FT   VAR_SEQ         133..204
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_026513"
FT   VAR_SEQ         167..204
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_026514"
FT   CONFLICT        139
FT                   /note="T -> S (in Ref. 5; AAH33818)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   204 AA;  22349 MW;  79917025B4C8425E CRC64;
     MGAPLAVALG ALHYLALFLQ LGGATRPAGH APWDNHVSGH ALFTETPHDM TARTGEDVEM
     ACSFRGSGSP SYSLEIQWWY VRSHRDWTDK QAWASNQLKA SQQEDAGKEA TKISVVKVVG
     SNISHKLRLS RVKPTDEGTY ECRVIDFSDG KARHHKVKAY LRVQPGENSV LHLPEAPPAA
     PAPPPPKPGK ELRKRSVDQE ACSL
 
 
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