ID   VTS1_ASHGO              Reviewed;         490 AA.
AC   Q758Y4;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2013, sequence version 2.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=RNA-binding protein VTS1;
GN   Name=VTS1; OrderedLocusNames=ADR394W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION, AND SEQUENCE REVISION TO 207.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: RNA-binding protein involved in post-transcriptional
CC       regulation through transcript degradation.
CC       {ECO:0000250|UniProtKB:Q08831}.
CC   -!- SUBUNIT: Monomer. Binds to RNA. {ECO:0000250|UniProtKB:Q08831}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:Q08831}. Cytoplasm, P-body
CC       {ECO:0000250|UniProtKB:J9VVN9}.
CC   -!- SIMILARITY: Belongs to the VTS1 family. {ECO:0000305}.
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DR   EMBL; AE016817; AAS52313.2; -; Genomic_DNA.
DR   RefSeq; NP_984489.2; NM_209842.2.
DR   AlphaFoldDB; Q758Y4; -.
DR   SMR; Q758Y4; -.
DR   STRING; 33169.AAS52313; -.
DR   EnsemblFungi; AAS52313; AAS52313; AGOS_ADR394W.
DR   GeneID; 4620654; -.
DR   KEGG; ago:AGOS_ADR394W; -.
DR   eggNOG; KOG3791; Eukaryota.
DR   HOGENOM; CLU_595905_0_0_1; -.
DR   InParanoid; Q758Y4; -.
DR   OMA; QQNTVMD; -.
DR   Proteomes; UP000000591; Chromosome IV.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:EnsemblFungi.
DR   GO; GO:0000932; C:P-body; IBA:GO_Central.
DR   GO; GO:0070336; F:flap-structured DNA binding; IEA:EnsemblFungi.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0030371; F:translation repressor activity; IBA:GO_Central.
DR   GO; GO:0000289; P:nuclear-transcribed mRNA poly(A) tail shortening; IBA:GO_Central.
DR   GO; GO:0032079; P:positive regulation of endodeoxyribonuclease activity; IEA:EnsemblFungi.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   CDD; cd09556; SAM_VTS1_fungal; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR037635; VTS1_SAM.
DR   Pfam; PF07647; SAM_2; 1.
DR   SMART; SM00454; SAM; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS50105; SAM_DOMAIN; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleotide-binding; Protein transport; Reference proteome;
KW   RNA-binding; Transport.
FT   CHAIN           1..490
FT                   /note="RNA-binding protein VTS1"
FT                   /id="PRO_0000081446"
FT   DOMAIN          418..479
FT                   /note="SAM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00184"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          71..90
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          305..410
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..19
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        321..410
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   490 AA;  51513 MW;  3F7660EA3038139C CRC64;
     MMSGYNGDGV SSLPTRTQSP LARGAHPGAV LLSPKRTALG TLGGGAGGSS AQLMSPSQHS
     LSLNDILDQQ AHPSRVDSSS AMSLDASIHQ QQHTSGVGML SPLLQPQASS ISVKTAFLDS
     FGSRPSSAIG LQHGQGQGPD GPQSATGMSL NNSNIMVNFT NDVNQLCTWM SMLTSAQQNT
     VMDNLLSSLN EEVLQHTKLK LESLTNSGYL SPSLRPIASP IPSRVATLET STQSASSAQL
     PGSLMLDSIL SDSAAAGAGS TNSNNTNMAS HSLAVNSMYR QWSPSPQMNS AQPMFDYLND
     ITRPRSAEPS RLRNGHTSHH QNGSHHIAMN SGNGAPPNSH SSTGHQVSSQ AGGRFSNIKP
     QRPHSPTSLT KSTSSSSNFS EAQSPAAQPT SPGPSTPNAA SNVSSSSNMN PKSLCDPKLL
     KNIPAWLKSL RLHKYSASLN GKSWQELIDL DDAILEDMGV SALGARRKLL KAFAIVKECK
     ERGLVDESAY