VTS1_CANAL
ID VTS1_CANAL Reviewed; 679 AA.
AC Q5AI80; A0A1D8PCW8; O94033;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2017, sequence version 2.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=RNA-binding protein VTS1;
GN Name=VTS1; OrderedLocusNames=CAALFM_C102850WA;
GN ORFNames=Ca49C10.19, CaO19.10490, CaO19.2973;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1161;
RA Oliver K., Harris D., Barrell B.G., Rajandream M.A.;
RT "Candida albicans strain 1161 genome pilot sequencing project.";
RL Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- FUNCTION: RNA-binding protein involved in post-transcriptional
CC regulation through transcript degradation.
CC {ECO:0000250|UniProtKB:Q08831}.
CC -!- SUBUNIT: Monomer. Binds to RNA. {ECO:0000250|UniProtKB:Q08831}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000250|UniProtKB:Q08831}. Cytoplasm, P-body
CC {ECO:0000250|UniProtKB:J9VVN9}.
CC -!- SIMILARITY: Belongs to the VTS1 family. {ECO:0000305}.
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DR EMBL; AL033497; CAA21983.1; -; Genomic_DNA.
DR EMBL; CP017623; AOW25966.1; -; Genomic_DNA.
DR PIR; T52163; T52163.
DR RefSeq; XP_721472.2; XM_716379.2.
DR AlphaFoldDB; Q5AI80; -.
DR SMR; Q5AI80; -.
DR STRING; 237561.Q5AI80; -.
DR PRIDE; Q5AI80; -.
DR GeneID; 3636862; -.
DR KEGG; cal:CAALFM_C102850WA; -.
DR CGD; CAL0000193097; orf19.10490.
DR VEuPathDB; FungiDB:C1_02850W_A; -.
DR eggNOG; KOG3791; Eukaryota.
DR HOGENOM; CLU_443421_0_0_1; -.
DR InParanoid; Q5AI80; -.
DR OrthoDB; 1068685at2759; -.
DR PRO; PR:Q5AI80; -.
DR Proteomes; UP000000559; Chromosome 1.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0000932; C:P-body; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0030371; F:translation repressor activity; IBA:GO_Central.
DR GO; GO:0000289; P:nuclear-transcribed mRNA poly(A) tail shortening; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd09556; SAM_VTS1_fungal; 1.
DR Gene3D; 1.10.150.50; -; 1.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR037635; VTS1_SAM.
DR Pfam; PF07647; SAM_2; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF47769; SSF47769; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleotide-binding; Protein transport; Reference proteome;
KW RNA-binding; Transport.
FT CHAIN 1..679
FT /note="RNA-binding protein VTS1"
FT /id="PRO_0000081448"
FT DOMAIN 614..675
FT /note="SAM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00184"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 79..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 179..239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 469..502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 516..604
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..50
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 474..502
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 178
FT /note="S -> G (in Ref. 1; CAA21983)"
FT /evidence="ECO:0000305"
FT CONFLICT 384
FT /note="Y -> H (in Ref. 1; CAA21983)"
FT /evidence="ECO:0000305"
FT CONFLICT 549
FT /note="I -> V (in Ref. 1; CAA21983)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 679 AA; 74745 MW; 46E20948F294BE34 CRC64;
MEQSQGNIAN SPPTSEIPQR PIILSPPPLD QNSLNQSFNN LPTSVPQGHA NRQQSVGYNL
QHEFETLTAN LDLDLNSSTR NITQSAPPNQ QQQQQSQLQA TDSQLLTTTA DLNTKPAHSV
KPTLAAPAAS RYGSHLGSDL LGKSTSSLLG DNNPVSPIQK FSSINTQLDS LLNNNISSAK
SKTGTNSPFL SNAGLSNRPQ SVNDFSNIFN RQDQQQQQQS QTFSSFTTQQ QSQNQNQNQN
QSNFYSDLIV FSNWIENLNP QDNLTMIDYL CSNLPLDILL TFKSKLDLHL QGGSAQNQQS
QQSQLLPQFV MSPYSQYDQQ LYNDMDKLNI QDDSFKSKHG NSSFRSNHLA NLIDKVERPK
SADPFVNNTK YGQYQQQSYN QHSYQQQHPL VDRAKSPTSH LYEKTNFLQL AAANSNNTGG
NYNQYMPSLS STSSSLGQAN SNNTSTRDDM DLKLGALATI NSRVALDSNR KHPHVATPGS
TWNNQTHTHS HISPPHHNQM HSGVRNVSNF EESINRSLNS SSVPASMHKS NYSNSHGNNS
NNNSGNTNIN SNQNKGTHKK KINSPTSAVS MQQNSTSVNS TTSGNGGANA NVNTTATTSS
SSSSSMPIEV SSLELLNNIP AWLKLLRLHK YTECLKDVPW KELIELDNDQ LESKGVAALG
ARRKLLKAFD VVKNNLPVV
