ID   VTS1_CANGA              Reviewed;         549 AA.
AC   Q6FM94;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=RNA-binding protein VTS1;
GN   Name=VTS1; OrderedLocusNames=CAGL0K09922g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: RNA-binding protein involved in post-transcriptional
CC       regulation through transcript degradation.
CC       {ECO:0000250|UniProtKB:Q08831}.
CC   -!- SUBUNIT: Monomer. Binds to RNA. {ECO:0000250|UniProtKB:Q08831}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:Q08831}. Cytoplasm, P-body
CC       {ECO:0000250|UniProtKB:J9VVN9}.
CC   -!- SIMILARITY: Belongs to the VTS1 family. {ECO:0000305}.
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DR   EMBL; CR380957; CAG61613.1; -; Genomic_DNA.
DR   RefSeq; XP_448650.1; XM_448650.1.
DR   AlphaFoldDB; Q6FM94; -.
DR   SMR; Q6FM94; -.
DR   STRING; 5478.XP_448650.1; -.
DR   EnsemblFungi; CAG61613; CAG61613; CAGL0K09922g.
DR   GeneID; 2890206; -.
DR   KEGG; cgr:CAGL0K09922g; -.
DR   CGD; CAL0134917; CAGL0K09922g.
DR   VEuPathDB; FungiDB:CAGL0K09922g; -.
DR   eggNOG; KOG3791; Eukaryota.
DR   HOGENOM; CLU_595905_0_0_1; -.
DR   InParanoid; Q6FM94; -.
DR   OMA; QQNTVMD; -.
DR   Proteomes; UP000002428; Chromosome K.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0000932; C:P-body; IEA:UniProtKB-SubCell.
DR   GO; GO:0003729; F:mRNA binding; IEA:InterPro.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0043488; P:regulation of mRNA stability; IEA:InterPro.
DR   CDD; cd09556; SAM_VTS1_fungal; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR037635; VTS1_SAM.
DR   Pfam; PF07647; SAM_2; 1.
DR   SMART; SM00454; SAM; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS50105; SAM_DOMAIN; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleotide-binding; Protein transport; Reference proteome;
KW   RNA-binding; Transport.
FT   CHAIN           1..549
FT                   /note="RNA-binding protein VTS1"
FT                   /id="PRO_0000081449"
FT   DOMAIN          473..534
FT                   /note="SAM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00184"
FT   REGION          1..57
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          113..155
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          181..206
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          256..293
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          371..422
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          435..470
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        18..56
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   549 AA;  59830 MW;  912583744BC73D53 CRC64;
     MLANKFDEMH HPVPDSSMNG NPLCNSSANV GQGNRNSNPI QSRGTGHSSS PIYNNPLRTA
     HPGAVLLSPQ SSSLNIIDTT VGNAMSPTVP SSAASSIFFN DFGLDSSTNL NKSAMNANSN
     RPMTTIPLSS NSTSQSYTLS FQQENKKTNS NSTLNNVNNG LVTAGSVSNS HNNIFLDSFL
     SHDNTMQPNN SSNNNNNNNQ NANNSLNFNT DVNQLCTWMS MLTANQQSVV MDNIISVLNE
     STLNYTKMKL DTMFGTTSSS PTSAEAMQNL GQPKESGNQN SNQNNIASPI PSTLDSVFAN
     NSMKYLQSQS TSGSNHFHQA FNSKGSSMNW SSQASNIQNP AYDYLNDYRQ RPKSAEPPLS
     HQTHYQPSNL SISQFKPQNS NGNSSNTNTN RNLNNSNNSN NNSTANNNNI GSNNTKRMND
     ITNSADVPVT SSFQNLTLNN QNGSTTTSSN NGNSSSGASS NSSMNPKSLT DPKLLNNIPI
     WLKTLRLHKY SDILNDLSWE KLIYLEDEDL LKRGVLALGA RRKLLKAFTI VRDYKNRDLI
     DNSAYLNIK