ID   VTS1_KLULA              Reviewed;         459 AA.
AC   Q6CY29;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=RNA-binding protein VTS1;
GN   Name=VTS1; OrderedLocusNames=KLLA0A03641g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: RNA-binding protein involved in post-transcriptional
CC       regulation through transcript degradation.
CC       {ECO:0000250|UniProtKB:Q08831}.
CC   -!- SUBUNIT: Monomer. Binds to RNA. {ECO:0000250|UniProtKB:Q08831}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:Q08831}. Cytoplasm, P-body
CC       {ECO:0000250|UniProtKB:J9VVN9}.
CC   -!- SIMILARITY: Belongs to the VTS1 family. {ECO:0000305}.
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DR   EMBL; CR382121; CAH02748.1; -; Genomic_DNA.
DR   RefSeq; XP_451160.1; XM_451160.1.
DR   AlphaFoldDB; Q6CY29; -.
DR   SMR; Q6CY29; -.
DR   STRING; 28985.XP_451160.1; -.
DR   EnsemblFungi; CAH02748; CAH02748; KLLA0_A03641g.
DR   GeneID; 2896691; -.
DR   KEGG; kla:KLLA0_A03641g; -.
DR   eggNOG; KOG3791; Eukaryota.
DR   HOGENOM; CLU_595905_0_0_1; -.
DR   InParanoid; Q6CY29; -.
DR   OMA; QQNTVMD; -.
DR   Proteomes; UP000000598; Chromosome A.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:EnsemblFungi.
DR   GO; GO:0000932; C:P-body; IEA:UniProtKB-SubCell.
DR   GO; GO:0070336; F:flap-structured DNA binding; IEA:EnsemblFungi.
DR   GO; GO:0003729; F:mRNA binding; IEA:InterPro.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0000289; P:nuclear-transcribed mRNA poly(A) tail shortening; IEA:EnsemblFungi.
DR   GO; GO:0032079; P:positive regulation of endodeoxyribonuclease activity; IEA:EnsemblFungi.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   CDD; cd09556; SAM_VTS1_fungal; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR037635; VTS1_SAM.
DR   Pfam; PF07647; SAM_2; 1.
DR   SMART; SM00454; SAM; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS50105; SAM_DOMAIN; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleotide-binding; Protein transport; Reference proteome;
KW   RNA-binding; Transport.
FT   CHAIN           1..459
FT                   /note="RNA-binding protein VTS1"
FT                   /id="PRO_0000081453"
FT   DOMAIN          387..448
FT                   /note="SAM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00184"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          259..336
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..16
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        268..336
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   459 AA;  49749 MW;  4668478A4F7C8530 CRC64;
     MSSQNMLSSL PGRTQSPVNL PRGAHPGAVL LSPKGSSANL QALGTNPTSP SQQPLFLNDL
     LNQQQFSLDS QLHLRDDLGR PSNMVSPLSN SAMNPTASNG STFLDTFSRP TSSMAINHQP
     LPLQHSNSNA NVMVNFTNDV NQLCNWISML TPSQQNTVMD NLLSSLNEEV LHSTKLKLDS
     LVHSGYISPQ LGPIASPIPN KVQSQVHQAE NPQPLNLDSV LNGDNIYRQW SPLPQNTASP
     MQQPMYDYLA DIPRPRSADP YNAFKKGGLS SGNANNNSNN GNAISNLNSS NPFGTNTVSS
     TNMSNSNSSS SATGRKNMNQ NQHQNQYLNR PQSPTNIKAN VFNKTSLATS SSNSGNALTT
     VNSASSTTSN FNCTNNSMNA KGLCDPKLLK NVPAWLKSLR LHKYSEALGS KPWFELIYLD
     DEALENMGVS ALGARRKLLK AFSIVREYKA NDMIDSSAF