VTS1_NEUCR
ID VTS1_NEUCR Reviewed; 620 AA.
AC Q7RZQ3; U9W515;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 19-FEB-2014, sequence version 3.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=RNA-binding protein VTS1;
GN Name=vts1; ORFNames=NCU00311;
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- FUNCTION: RNA-binding protein involved in post-transcriptional
CC regulation through transcript degradation.
CC {ECO:0000250|UniProtKB:Q08831}.
CC -!- SUBUNIT: Monomer. Binds to RNA. {ECO:0000250|UniProtKB:Q08831}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000250|UniProtKB:Q08831}. Cytoplasm, P-body
CC {ECO:0000250|UniProtKB:J9VVN9}.
CC -!- SIMILARITY: Belongs to the VTS1 family. {ECO:0000305}.
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DR EMBL; CM002238; ESA43334.1; -; Genomic_DNA.
DR EMBL; CM002238; ESA43335.1; -; Genomic_DNA.
DR RefSeq; XP_011393809.1; XM_011395507.1.
DR RefSeq; XP_011393810.1; XM_011395508.1.
DR AlphaFoldDB; Q7RZQ3; -.
DR SMR; Q7RZQ3; -.
DR STRING; 5141.EFNCRP00000000389; -.
DR EnsemblFungi; ESA43334; ESA43334; NCU00311.
DR EnsemblFungi; ESA43335; ESA43335; NCU00311.
DR GeneID; 3873920; -.
DR KEGG; ncr:NCU00311; -.
DR VEuPathDB; FungiDB:NCU00311; -.
DR HOGENOM; CLU_017632_0_0_1; -.
DR InParanoid; Q7RZQ3; -.
DR Proteomes; UP000001805; Chromosome 3, Linkage Group III.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0000932; C:P-body; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0030371; F:translation repressor activity; IBA:GO_Central.
DR GO; GO:0000289; P:nuclear-transcribed mRNA poly(A) tail shortening; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd09556; SAM_VTS1_fungal; 1.
DR Gene3D; 1.10.150.50; -; 1.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR037635; VTS1_SAM.
DR Pfam; PF07647; SAM_2; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF47769; SSF47769; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleotide-binding; Protein transport; Reference proteome;
KW RNA-binding; Transport.
FT CHAIN 1..620
FT /note="RNA-binding protein VTS1"
FT /id="PRO_0000081454"
FT DOMAIN 553..614
FT /note="SAM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00184"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 189..211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 231..317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 398..423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 527..555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..29
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 231..296
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 404..423
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 527..546
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 620 AA; 66842 MW; A642BC5C1E3670ED CRC64;
MLNMSNIMSN RNSTPEASNV SSLRPPSSRA IGSNHGLRAS ADVAALTGAQ AAASRIRPSS
DFYGQPQSGQ VQGNAELDPQ DKLAQQWIAD IDQYETTLEE MAAATLDQDF KDELSAIEQW
FRVLSEAERT AALYALLQQT TQVQIRFFIQ VLQQMGKNHP MSGVLSPANF DKDPMSSRLS
DAMGKLEVGS ARNSLARPSG GANKRHSGLD QTTINTMFPD AVAAIATEKA KFTQQTGNPP
PSNRNSLVDN RNSLAAPTVS GPKDDINGQN PASPWGPSDT SRPKSSTGQT PMGQFVQPPP
SAGGLRSPRP PQLSSNTNIQ STTLTAAEPQ LTELPLLSPY TSSGNWASMV NTPMVPTFGQ
TQGNNADMVA NATAMKLAAL STVNNRFALD DARRYRRARS NDGAPGQSHA QHPLSPGPQG
IPSTNVVMIN EHGQVLSHDH VLALQQQQQQ GLQQGLGGFG GHRSRPTSPG IAMPNYGSAL
QFTSPQNNGF LSAYDGGAPG LINNGLVPMM GQFNLGGHHA EGYLSDHSEI NRGRSPRGRR
GSSKPPEDPT DPTLLQDIPS WLRSLRLHKY TDNLKDMKWT DLIELDDKQL EERGVNALGA
RRKMLKVFEQ VKEAKKEGKI
