VTS1_SCHPO
ID VTS1_SCHPO Reviewed; 713 AA.
AC Q9P6R7;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 106.
DE RecName: Full=RNA-binding protein vts1;
GN ORFNames=SPBC13E7.03c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-673, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- FUNCTION: RNA-binding protein involved in post-transcriptional
CC regulation through transcript degradation.
CC {ECO:0000250|UniProtKB:Q08831}.
CC -!- SUBUNIT: Monomer. Binds to RNA. {ECO:0000250|UniProtKB:Q08831}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000250|UniProtKB:Q08831}. Cytoplasm, P-body
CC {ECO:0000250|UniProtKB:J9VVN9}.
CC -!- SIMILARITY: Belongs to the VTS1 family. {ECO:0000305}.
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DR EMBL; CU329671; CAB89878.1; -; Genomic_DNA.
DR RefSeq; NP_596258.1; NM_001022178.2.
DR AlphaFoldDB; Q9P6R7; -.
DR SMR; Q9P6R7; -.
DR BioGRID; 276696; 64.
DR STRING; 4896.SPBC13E7.03c.1; -.
DR iPTMnet; Q9P6R7; -.
DR MaxQB; Q9P6R7; -.
DR PaxDb; Q9P6R7; -.
DR PRIDE; Q9P6R7; -.
DR EnsemblFungi; SPBC13E7.03c.1; SPBC13E7.03c.1:pep; SPBC13E7.03c.
DR GeneID; 2540161; -.
DR KEGG; spo:SPBC13E7.03c; -.
DR PomBase; SPBC13E7.03c; -.
DR VEuPathDB; FungiDB:SPBC13E7.03c; -.
DR eggNOG; KOG3791; Eukaryota.
DR HOGENOM; CLU_383178_0_0_1; -.
DR InParanoid; Q9P6R7; -.
DR OMA; PQDIPSW; -.
DR PRO; PR:Q9P6R7; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0000932; C:P-body; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0030371; F:translation repressor activity; IBA:GO_Central.
DR GO; GO:0000289; P:nuclear-transcribed mRNA poly(A) tail shortening; ISO:PomBase.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd09556; SAM_VTS1_fungal; 1.
DR Gene3D; 1.10.150.50; -; 1.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR037635; VTS1_SAM.
DR Pfam; PF07647; SAM_2; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF47769; SSF47769; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Nucleotide-binding; Phosphoprotein; Protein transport;
KW Reference proteome; RNA-binding; Transport.
FT CHAIN 1..713
FT /note="RNA-binding protein vts1"
FT /id="PRO_0000081455"
FT DOMAIN 595..656
FT /note="SAM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00184"
FT REGION 154..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 254..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 356..389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 554..596
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 667..713
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 254..327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 367..382
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 554..572
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 673
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 713 AA; 77869 MW; CE58C775C17ED351 CRC64;
MEVVEGRRKT CLDVVDSPSS RQKQTIAVSL VDGKNYPTRF LNSRTIDKLK QELNTSNLST
GEMSTNETLK NAQEVAGKLL SEENEDSISE HFDEYLGADK PGISFLTRLK TLESWFQSLS
LQDRLTTLRT LLHHLPSQEI STLLSSSLTS SPSNSGLSLD KSLPSSPKGD SPSLSSSLPS
LTTKSNLSGN LNMVTPASTQ GPAFSSKHGF SNALSTASPI PVRTSSVSST YLTQDREASS
KNCLSKALAF SSIEPPASSA STSPRNTPTP SNNGTSINAN VTSSLTSNST GKTSKTTDLL
IAASKKSLPS NSTPSKPNTS FFETPHNNIW DSRDRGAFSA PPAPFFPLGF SPHLNDESSR
SRWSNISYSP PPPPPPPELL NHSPKSRPLG DKPYLFYRNN QIGPRTRTEG RSSITEGKPF
LSSSLRFEHV PSANDLNSVV NARVEKSTGQ PSTPLNRQHY FNELPHSTTP VTLPSLIHGS
EIDRRRSGFC LNNFNSTPPF QPYHYEIGSG LPQQMHATNT ILTNPIDPNS NISTPVGMHL
CTLPYTYQPF SSVEKIETPP NNSKNQTYRR SSRGSNKTRK SISHSKNTDK HVGNELPQDI
PSWLRSLRLH KYTNNLKDTD WDALVSLSDL DLQNRGIMAL GARRKLLKSF QEVAPLVSSK
KMNENLKAAK NQSSESLTSF KGHTDSEDLP SGSMSNEISS NSTKQDVSSS SMD
