VTU2_DROME
ID VTU2_DROME Reviewed; 168 AA.
AC P13238; A4UM08; Q9VMK6;
DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 2.
DT 03-AUG-2022, entry version 160.
DE RecName: Full=Vitelline membrane protein Vm26Ab;
DE AltName: Full=Protein SV23;
DE AltName: Full=Protein TU-4;
DE Flags: Precursor;
GN Name=Vm26Ab; ORFNames=CG9046;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RX PubMed=3132408; DOI=10.1016/0012-1606(88)90312-0;
RA Popodi E., Minoo P., Burke T., Waring G.L.;
RT "Organization and expression of a second chromosome follicle cell gene
RT cluster in Drosophila.";
RL Dev. Biol. 127:248-256(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=17244601; DOI=10.1093/molbev/msm009;
RA Jagadeeshan S., Singh R.S.;
RT "Rapid evolution of outer egg membrane proteins in the Drosophila
RT melanogaster subgroup: a case of ecologically driven evolution of female
RT reproductive traits.";
RL Mol. Biol. Evol. 24:929-938(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
CC -!- FUNCTION: Major early eggshell protein. {ECO:0000269|PubMed:3132408}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Follicle cells. {ECO:0000269|PubMed:3132408}.
CC -!- DEVELOPMENTAL STAGE: Expressed during vitelline membrane biosynthesis.
CC {ECO:0000269|PubMed:3132408}.
CC -!- DOMAIN: The tetrapeptide (A-A-P-[AV]) repeats found throughout the
CC protein are also present in many proteins constituting the protective
CC envelope of other species.
CC -!- SIMILARITY: Belongs to the vitelline membrane protein family.
CC {ECO:0000305}.
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DR EMBL; M20936; AAA28984.1; -; Genomic_DNA.
DR EMBL; EF441676; ABO71717.1; -; Genomic_DNA.
DR EMBL; AE014134; AAF52308.1; -; Genomic_DNA.
DR PIR; A45943; A45943.
DR RefSeq; NP_001285648.1; NM_001298719.1.
DR RefSeq; NP_476784.1; NM_057436.2.
DR AlphaFoldDB; P13238; -.
DR BioGRID; 59992; 24.
DR DIP; DIP-19185N; -.
DR IntAct; P13238; 19.
DR STRING; 7227.FBpp0078802; -.
DR PaxDb; P13238; -.
DR DNASU; 33827; -.
DR EnsemblMetazoa; FBtr0079171; FBpp0078802; FBgn0003980.
DR EnsemblMetazoa; FBtr0345439; FBpp0311564; FBgn0003980.
DR GeneID; 33827; -.
DR KEGG; dme:Dmel_CG9046; -.
DR CTD; 33827; -.
DR FlyBase; FBgn0003980; Vm26Ab.
DR VEuPathDB; VectorBase:FBgn0003980; -.
DR eggNOG; ENOG502TB8D; Eukaryota.
DR HOGENOM; CLU_1671188_0_0_1; -.
DR InParanoid; P13238; -.
DR OMA; FNIGHIF; -.
DR OrthoDB; 1581258at2759; -.
DR PhylomeDB; P13238; -.
DR SignaLink; P13238; -.
DR BioGRID-ORCS; 33827; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 33827; -.
DR PRO; PR:P13238; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0003980; Expressed in adult abdomen and 14 other tissues.
DR ExpressionAtlas; P13238; baseline and differential.
DR Genevisible; P13238; DM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0060388; C:vitelline envelope; IDA:FlyBase.
DR GO; GO:0007304; P:chorion-containing eggshell formation; HMP:FlyBase.
DR GO; GO:0007343; P:egg activation; IMP:FlyBase.
DR GO; GO:0009617; P:response to bacterium; HEP:FlyBase.
DR GO; GO:0007305; P:vitelline membrane formation involved in chorion-containing eggshell formation; IMP:FlyBase.
DR InterPro; IPR013135; Vitelline_membr_Cys-rich-dom.
DR Pfam; PF10542; Vitelline_membr; 1.
DR PROSITE; PS51137; VM; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..168
FT /note="Vitelline membrane protein Vm26Ab"
FT /id="PRO_0000022676"
FT REPEAT 52..60
FT /note="1; approximate"
FT REPEAT 61..68
FT /note="2"
FT REPEAT 72..79
FT /note="3"
FT REPEAT 80..87
FT /note="4"
FT REPEAT 88..95
FT /note="5"
FT REPEAT 96..103
FT /note="6"
FT REPEAT 104..111
FT /note="7"
FT REPEAT 112..119
FT /note="8; approximate"
FT DOMAIN 117..154
FT /note="VM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00483"
FT REGION 52..119
FT /note="8 X 8 AA approximate repeats of Y-S-A-P-A-A-P-A"
FT CONFLICT 140
FT /note="C -> L (in Ref. 1; AAA28984)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 168 AA; 16771 MW; FA6B6DF4F7AB9E2F CRC64;
MAFNFGHLLI AGLVALSAVS SETIQLQPTQ GILIPAPLAE NIRVSRAAYG GYGAAPAAPS
YSAPAAPAAQ AYSAPAAPAY SAPAAPAYSA PAAPAYSAPA APAYSAPAAP AYSAPASIPS
PPCPKNYLFS CQPSLQPVPC SAPAQSYGSA GAYSQYVPQY AVPFVREL
