VTU3_DROME
ID VTU3_DROME Reviewed; 119 AA.
AC Q06521; A0JQ51; A0JQ52; A4UM24; Q9VJY2;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2005, sequence version 2.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Vitelline membrane protein Vm34Ca;
DE Flags: Precursor;
GN Name=Vm34Ca; Synonyms=VM34C.1; ORFNames=CG9271;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=8293994; DOI=10.1016/0378-1119(93)90455-c;
RA Scherer L.J., Harris D.H., White M.K., Steel L.S., Jin J., Petri W.H.;
RT "Comparative analysis of the sequence and structure of two Drosophila
RT melanogaster genes encoding vitelline membrane proteins.";
RL Gene 136:121-127(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=17244601; DOI=10.1093/molbev/msm009;
RA Jagadeeshan S., Singh R.S.;
RT "Rapid evolution of outer egg membrane proteins in the Drosophila
RT melanogaster subgroup: a case of ecologically driven evolution of female
RT reproductive traits.";
RL Mol. Biol. Evol. 24:929-938(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Kapadia B.,
RA Pacleb J.M., Park S., Wan K.H., Yu C., Celniker S.E.;
RL Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-96.
RC STRAIN=Daekwanryeong;
RX PubMed=3926479; DOI=10.1002/j.1460-2075.1985.tb02329.x;
RA Mindrinos M.N., Scherer L.J., Garcini F.J., Kwan H., Jacobs K.A.,
RA Petri W.H.;
RT "Isolation and chromosomal location of putative vitelline membrane genes in
RT Drosophila melanogaster.";
RL EMBO J. 4:147-153(1985).
RN [7]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-106.
RC STRAIN=Oregon-R; TISSUE=Embryo;
RX PubMed=3143615; DOI=10.1016/0012-1606(88)90367-3;
RA Scherer L.J., Harris D.H., Petri W.H.;
RT "Drosophila vitelline membrane genes contain a 114 base pair region of
RT highly conserved coding sequence.";
RL Dev. Biol. 130:786-788(1988).
CC -!- FUNCTION: Major early eggshell protein.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Follicle cells.
CC -!- DEVELOPMENTAL STAGE: Expressed during vitelline membrane biosynthesis.
CC -!- SIMILARITY: Belongs to the vitelline membrane protein family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABK57078.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=ABK57079.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; L08852; AAC37200.1; -; Unassigned_DNA.
DR EMBL; EF441692; ABO71733.1; -; Genomic_DNA.
DR EMBL; AE014134; AAF53303.1; -; Genomic_DNA.
DR EMBL; BT023245; AAY55661.1; -; mRNA.
DR EMBL; BT029421; ABK57078.1; ALT_INIT; mRNA.
DR EMBL; BT029422; ABK57079.1; ALT_INIT; mRNA.
DR EMBL; X01802; CAA25933.1; -; mRNA.
DR EMBL; M22700; AAA29018.1; -; Genomic_DNA.
DR RefSeq; NP_476785.1; NM_057437.4.
DR AlphaFoldDB; Q06521; -.
DR BioGRID; 60793; 4.
DR IntAct; Q06521; 1.
DR STRING; 7227.FBpp0080099; -.
DR PaxDb; Q06521; -.
DR DNASU; 34758; -.
DR EnsemblMetazoa; FBtr0080521; FBpp0080099; FBgn0003983.
DR GeneID; 34758; -.
DR KEGG; dme:Dmel_CG9271; -.
DR CTD; 34758; -.
DR FlyBase; FBgn0003983; Vm34Ca.
DR VEuPathDB; VectorBase:FBgn0003983; -.
DR eggNOG; ENOG502T8PE; Eukaryota.
DR GeneTree; ENSGT00540000073505; -.
DR HOGENOM; CLU_2040499_0_0_1; -.
DR InParanoid; Q06521; -.
DR OMA; SQYAPVY; -.
DR PhylomeDB; Q06521; -.
DR SignaLink; Q06521; -.
DR BioGRID-ORCS; 34758; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 34758; -.
DR PRO; PR:Q06521; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0003983; Expressed in adult abdomen and 15 other tissues.
DR ExpressionAtlas; Q06521; baseline and differential.
DR Genevisible; Q06521; DM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0060388; C:vitelline envelope; ISS:FlyBase.
DR InterPro; IPR013135; Vitelline_membr_Cys-rich-dom.
DR Pfam; PF10542; Vitelline_membr; 1.
DR PROSITE; PS51137; VM; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..119
FT /note="Vitelline membrane protein Vm34Ca"
FT /id="PRO_0000022677"
FT DOMAIN 69..106
FT /note="VM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00483"
FT CONFLICT 52..56
FT /note="PQAYA -> SPGLR (in Ref. 1; AAC37200 and 6;
FT CAA25933)"
FT /evidence="ECO:0000305"
FT CONFLICT 96
FT /note="A -> R (in Ref. 6; CAA25933)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 119 AA; 11954 MW; 85BFE4488904488D CRC64;
MKCIAIVSTI CLLAAFVAAD KEDKMLGSSY GGGYGKPAAA PAPSYSAPAA APQAYAAPAA
PSYAAAPVSI PAPPCPKNYL FSCQPNLAPV PCSAPAPSYG SAGAYSQYAP VYAPQPIQW
