ID   VU51_HHV6Z              Reviewed;         301 AA.
AC   P52542;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   23-FEB-2022, entry version 83.
DE   RecName: Full=G-protein coupled receptor homolog U51;
GN   Name=U51; Synonyms=KA12R;
OS   Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic
OS   virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=36351;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7983761; DOI=10.1128/jvi.69.1.589-596.1995;
RA   Stamey F.R., Dominguez G., Black J.B., Dambaugh T.R., Pellett P.E.;
RT   "Intragenomic linear amplification of human herpesvirus 6B oriLyt suggests
RT   acquisition of oriLyt by transposition.";
RL   J. Virol. 69:589-596(1995).
CC   -!- SUBCELLULAR LOCATION: Host cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AF157706; AAB06349.1; -; Genomic_DNA.
DR   PIR; T44011; T44011.
DR   RefSeq; NP_050232.1; NC_000898.1.
DR   SMR; P52542; -.
DR   PRIDE; P52542; -.
DR   DNASU; 1497053; -.
DR   GeneID; 1497053; -.
DR   KEGG; vg:1497053; -.
DR   Proteomes; UP000006930; Genome.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   G-protein coupled receptor; Glycoprotein; Host cell membrane;
KW   Host membrane; Membrane; Receptor; Reference proteome; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..301
FT                   /note="G-protein coupled receptor homolog U51"
FT                   /id="PRO_0000070257"
FT   TOPO_DOM        1..15
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        16..36
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        37..48
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        49..69
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        70..82
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        83..103
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        104..122
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        123..143
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        144..168
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        169..189
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        190..199
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        200..220
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        221..238
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        260..301
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        153
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   301 AA;  34482 MW;  2C31A5E483AE6F2E CRC64;
     MEKETKSLAW PATAEFYGWV FIFSSIQLCT VVFLTVRFNG FKVGREYAVF TFAGMSFNCF
     LLPIKMGLLS GHWTLPRDFC AILLYIDDFS AYFSSWSLVF MAIERINYFC YSTPLLNENS
     KALAKVCFPI VWVVSGVQAL QMLNNYKATA LQNETGQCFL AFLRSGHDMW LMLVYSVVIP
     VMLVFFYLYS KNFMLLKDEL SSVTTYLCIY LLLGTIAHLP KAALSEIESD KIFYGLRDIF
     MALPVLKVYY ISAMAYCMAC DDHTVPVRLC SIWLVNLCKK CFSCTRREKG SDLEVGIKML
     K