VUP1_ARATH
ID VUP1_ARATH Reviewed; 211 AA.
AC Q9LSZ3; Q8GRY6;
DT 25-OCT-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Vascular-related unknown protein 1 {ECO:0000303|PubMed:24567189};
GN Name=VUP1 {ECO:0000303|PubMed:24567189};
GN OrderedLocusNames=At3g21710 {ECO:0000312|Araport:AT3G21710};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:131-135(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=24567189; DOI=10.1104/pp.114.236406;
RA Grienenberger E., Douglas C.J.;
RT "Arabidopsis VASCULAR-RELATED UNKNOWN PROTEIN1 regulates xylem development
RT and growth by a conserved mechanism that modulates hormone signaling.";
RL Plant Physiol. 164:1991-2010(2014).
CC -!- FUNCTION: Involved in the regulation of xylem development and growth.
CC May regulate secondary wall formation during vascular development by
CC modulation of brassinosteroid, gibberellin and auxin hormone signaling
CC pathways. {ECO:0000269|PubMed:24567189}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24567189}. Nucleus
CC {ECO:0000269|PubMed:24567189}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9LSZ3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9LSZ3-2; Sequence=VSP_059134, VSP_059135;
CC -!- TISSUE SPECIFICITY: Expressed in vascular tissues of cotyledons,
CC rosette leaves, sepals, petals, anther filaments. Expressed in roots,
CC inflorescence stems and developing seeds.
CC {ECO:0000269|PubMed:24567189}.
CC -!- DISRUPTION PHENOTYPE: Collapsed xylem vessels in the inflorescence
CC stems. {ECO:0000269|PubMed:24567189}.
CC -!- MISCELLANEOUS: Plants overexpressing VUP1 exhibit severe dwarfism with
CC extreme short and round shaped organs, and display extreme longevity
CC before senescence. {ECO:0000269|PubMed:24567189}.
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DR EMBL; AB025634; BAB02833.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE76542.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE76543.1; -; Genomic_DNA.
DR EMBL; BT000445; AAN17422.1; -; mRNA.
DR EMBL; BT001217; AAN65104.1; -; mRNA.
DR RefSeq; NP_188808.2; NM_113066.3. [Q9LSZ3-2]
DR RefSeq; NP_974350.1; NM_202621.3. [Q9LSZ3-1]
DR AlphaFoldDB; Q9LSZ3; -.
DR STRING; 3702.AT3G21710.2; -.
DR iPTMnet; Q9LSZ3; -.
DR PaxDb; Q9LSZ3; -.
DR PRIDE; Q9LSZ3; -.
DR ProteomicsDB; 242711; -. [Q9LSZ3-1]
DR EnsemblPlants; AT3G21710.1; AT3G21710.1; AT3G21710. [Q9LSZ3-2]
DR EnsemblPlants; AT3G21710.2; AT3G21710.2; AT3G21710. [Q9LSZ3-1]
DR GeneID; 821725; -.
DR Gramene; AT3G21710.1; AT3G21710.1; AT3G21710. [Q9LSZ3-2]
DR Gramene; AT3G21710.2; AT3G21710.2; AT3G21710. [Q9LSZ3-1]
DR KEGG; ath:AT3G21710; -.
DR Araport; AT3G21710; -.
DR TAIR; locus:2093039; AT3G21710.
DR eggNOG; ENOG502S5I4; Eukaryota.
DR HOGENOM; CLU_092975_0_0_1; -.
DR InParanoid; Q9LSZ3; -.
DR OMA; CVHENSS; -.
DR OrthoDB; 1614924at2759; -.
DR PhylomeDB; Q9LSZ3; -.
DR PRO; PR:Q9LSZ3; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LSZ3; baseline and differential.
DR GO; GO:0005829; C:cytosol; IDA:TAIR.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0010089; P:xylem development; IMP:TAIR.
DR InterPro; IPR039280; VUP.
DR PANTHER; PTHR33974; PTHR33974; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..211
FT /note="Vascular-related unknown protein 1"
FT /id="PRO_0000441921"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 151..175
FT /note="GNIRGMGDHQIQIQEGGEQKVTLMR -> VISLTLFSIQIISLSILFAIEFI
FT NN (in isoform 2)"
FT /id="VSP_059134"
FT VAR_SEQ 176..211
FT /note="Missing (in isoform 2)"
FT /id="VSP_059135"
SQ SEQUENCE 211 AA; 23691 MW; 015F3F0D427AFF62 CRC64;
MMDTFSCNSY EQNHPHDDDI DIDAHDHDSH GGDHQEESGW TTYLDDFSNQ YRTTHHEEND
HQDKSSYSLL ATSTSLVSDA ATHAFSGKSF PVNFPAKLKF GRGRTKKICE DDSLEDTASS
PVNSPKVSHF EHIQTPPRKI EDYVSSSFVM GNIRGMGDHQ IQIQEGGEQK VTLMRNLIDG
NNNNNNNNMD LRSRGLCVVP ISMLANFNGR C