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VUP1_ARATH
ID   VUP1_ARATH              Reviewed;         211 AA.
AC   Q9LSZ3; Q8GRY6;
DT   25-OCT-2017, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Vascular-related unknown protein 1 {ECO:0000303|PubMed:24567189};
GN   Name=VUP1 {ECO:0000303|PubMed:24567189};
GN   OrderedLocusNames=At3g21710 {ECO:0000312|Araport:AT3G21710};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA   Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT   features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT   clones.";
RL   DNA Res. 7:131-135(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DISRUPTION
RP   PHENOTYPE.
RX   PubMed=24567189; DOI=10.1104/pp.114.236406;
RA   Grienenberger E., Douglas C.J.;
RT   "Arabidopsis VASCULAR-RELATED UNKNOWN PROTEIN1 regulates xylem development
RT   and growth by a conserved mechanism that modulates hormone signaling.";
RL   Plant Physiol. 164:1991-2010(2014).
CC   -!- FUNCTION: Involved in the regulation of xylem development and growth.
CC       May regulate secondary wall formation during vascular development by
CC       modulation of brassinosteroid, gibberellin and auxin hormone signaling
CC       pathways. {ECO:0000269|PubMed:24567189}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24567189}. Nucleus
CC       {ECO:0000269|PubMed:24567189}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9LSZ3-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9LSZ3-2; Sequence=VSP_059134, VSP_059135;
CC   -!- TISSUE SPECIFICITY: Expressed in vascular tissues of cotyledons,
CC       rosette leaves, sepals, petals, anther filaments. Expressed in roots,
CC       inflorescence stems and developing seeds.
CC       {ECO:0000269|PubMed:24567189}.
CC   -!- DISRUPTION PHENOTYPE: Collapsed xylem vessels in the inflorescence
CC       stems. {ECO:0000269|PubMed:24567189}.
CC   -!- MISCELLANEOUS: Plants overexpressing VUP1 exhibit severe dwarfism with
CC       extreme short and round shaped organs, and display extreme longevity
CC       before senescence. {ECO:0000269|PubMed:24567189}.
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DR   EMBL; AB025634; BAB02833.1; -; Genomic_DNA.
DR   EMBL; CP002686; AEE76542.1; -; Genomic_DNA.
DR   EMBL; CP002686; AEE76543.1; -; Genomic_DNA.
DR   EMBL; BT000445; AAN17422.1; -; mRNA.
DR   EMBL; BT001217; AAN65104.1; -; mRNA.
DR   RefSeq; NP_188808.2; NM_113066.3. [Q9LSZ3-2]
DR   RefSeq; NP_974350.1; NM_202621.3. [Q9LSZ3-1]
DR   AlphaFoldDB; Q9LSZ3; -.
DR   STRING; 3702.AT3G21710.2; -.
DR   iPTMnet; Q9LSZ3; -.
DR   PaxDb; Q9LSZ3; -.
DR   PRIDE; Q9LSZ3; -.
DR   ProteomicsDB; 242711; -. [Q9LSZ3-1]
DR   EnsemblPlants; AT3G21710.1; AT3G21710.1; AT3G21710. [Q9LSZ3-2]
DR   EnsemblPlants; AT3G21710.2; AT3G21710.2; AT3G21710. [Q9LSZ3-1]
DR   GeneID; 821725; -.
DR   Gramene; AT3G21710.1; AT3G21710.1; AT3G21710. [Q9LSZ3-2]
DR   Gramene; AT3G21710.2; AT3G21710.2; AT3G21710. [Q9LSZ3-1]
DR   KEGG; ath:AT3G21710; -.
DR   Araport; AT3G21710; -.
DR   TAIR; locus:2093039; AT3G21710.
DR   eggNOG; ENOG502S5I4; Eukaryota.
DR   HOGENOM; CLU_092975_0_0_1; -.
DR   InParanoid; Q9LSZ3; -.
DR   OMA; CVHENSS; -.
DR   OrthoDB; 1614924at2759; -.
DR   PhylomeDB; Q9LSZ3; -.
DR   PRO; PR:Q9LSZ3; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q9LSZ3; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IDA:TAIR.
DR   GO; GO:0005634; C:nucleus; IDA:TAIR.
DR   GO; GO:0010089; P:xylem development; IMP:TAIR.
DR   InterPro; IPR039280; VUP.
DR   PANTHER; PTHR33974; PTHR33974; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cytoplasm; Nucleus; Reference proteome.
FT   CHAIN           1..211
FT                   /note="Vascular-related unknown protein 1"
FT                   /id="PRO_0000441921"
FT   REGION          1..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        12..35
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         151..175
FT                   /note="GNIRGMGDHQIQIQEGGEQKVTLMR -> VISLTLFSIQIISLSILFAIEFI
FT                   NN (in isoform 2)"
FT                   /id="VSP_059134"
FT   VAR_SEQ         176..211
FT                   /note="Missing (in isoform 2)"
FT                   /id="VSP_059135"
SQ   SEQUENCE   211 AA;  23691 MW;  015F3F0D427AFF62 CRC64;
     MMDTFSCNSY EQNHPHDDDI DIDAHDHDSH GGDHQEESGW TTYLDDFSNQ YRTTHHEEND
     HQDKSSYSLL ATSTSLVSDA ATHAFSGKSF PVNFPAKLKF GRGRTKKICE DDSLEDTASS
     PVNSPKVSHF EHIQTPPRKI EDYVSSSFVM GNIRGMGDHQ IQIQEGGEQK VTLMRNLIDG
     NNNNNNNNMD LRSRGLCVVP ISMLANFNGR C
 
 
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