ID   VUP2_ARATH              Reviewed;         196 AA.
AC   Q9C6I7;
DT   25-OCT-2017, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Vascular-related unknown protein 2 {ECO:0000303|PubMed:24567189};
GN   Name=VUP2 {ECO:0000303|PubMed:24567189};
GN   OrderedLocusNames=At1g50930 {ECO:0000312|Araport:AT1G50930};
GN   ORFNames=F8A12.15 {ECO:0000312|EMBL:AAG50938.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W.,
RA   Redman J.C., Wu H.C., Utterback T., Town C.D.;
RT   "Reconstruction of cDNA sequences for hypothetical genes in Arabidopsis
RT   thaliana from 5' and 3' RACE products.";
RL   Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   FUNCTION.
RX   PubMed=24567189; DOI=10.1104/pp.114.236406;
RA   Grienenberger E., Douglas C.J.;
RT   "Arabidopsis VASCULAR-RELATED UNKNOWN PROTEIN1 regulates xylem development
RT   and growth by a conserved mechanism that modulates hormone signaling.";
RL   Plant Physiol. 164:1991-2010(2014).
CC   -!- FUNCTION: Involved in the regulation of plant growth.
CC       {ECO:0000269|PubMed:24567189}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=1;
CC         Comment=A number of isoforms are produced. According to EST
CC         sequences. {ECO:0000305};
CC       Name=1;
CC         IsoId=Q9C6I7-1; Sequence=Displayed;
CC   -!- MISCELLANEOUS: Plants overexpressing VUP2 exhibit severe dwarfism.
CC       {ECO:0000269|PubMed:24567189}.
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DR   EMBL; AC079284; AAG50938.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE32602.1; -; Genomic_DNA.
DR   EMBL; AY630765; AAT67564.1; -; mRNA.
DR   EMBL; AY924707; AAX23782.1; -; mRNA.
DR   PIR; D96546; D96546.
DR   RefSeq; NP_175506.1; NM_103973.3. [Q9C6I7-1]
DR   AlphaFoldDB; Q9C6I7; -.
DR   SMR; Q9C6I7; -.
DR   PaxDb; Q9C6I7; -.
DR   PRIDE; Q9C6I7; -.
DR   EnsemblPlants; AT1G50930.1; AT1G50930.1; AT1G50930. [Q9C6I7-1]
DR   GeneID; 841515; -.
DR   Gramene; AT1G50930.1; AT1G50930.1; AT1G50930. [Q9C6I7-1]
DR   KEGG; ath:AT1G50930; -.
DR   Araport; AT1G50930; -.
DR   TAIR; locus:2036457; AT1G50930.
DR   eggNOG; ENOG502R1GZ; Eukaryota.
DR   HOGENOM; CLU_092975_0_0_1; -.
DR   InParanoid; Q9C6I7; -.
DR   OMA; EIGCITE; -.
DR   PhylomeDB; Q9C6I7; -.
DR   PRO; PR:Q9C6I7; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q9C6I7; baseline and differential.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009825; P:multidimensional cell growth; IMP:UniProtKB.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0010089; P:xylem development; IEA:InterPro.
DR   InterPro; IPR039280; VUP.
DR   PANTHER; PTHR33974; PTHR33974; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Kinase; Reference proteome; Transferase.
FT   CHAIN           1..196
FT                   /note="Vascular-related unknown protein 2"
FT                   /id="PRO_0000441922"
FT   REGION          84..130
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        107..121
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   196 AA;  22697 MW;  46B3A715163D6352 CRC64;
     MENSVNNCVR QRVFSNHQIR MIHEEEDHEE SSWIVYFEDI DHDDEMVETE GEMTHYYDND
     SSMISDAASP VHTTKINNVV RRKANNINTN PKKRRIIHQH KEEEEEELQK GEEEEEDEED
     TASSPSNKTK IFSVLDHAND NTRYGKTMDN VTSEEIGCIT ETGSKIKEIM NEEFSAELKK
     RGLCVVPLSM LSNFIA