VVP1_BOTMO
ID VVP1_BOTMO Reviewed; 12 AA.
AC P84747;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 1.
DT 26-FEB-2020, entry version 27.
DE RecName: Full=1370.6 Da venom vasodilator peptide;
OS Bothrops moojeni (Lance-headed viper) (Caissaca).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Viperidae; Crotalinae; Bothrops.
OX NCBI_TaxID=98334;
RN [1] {ECO:0000305}
RP PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS
RP SPECTROMETRY, AND METHYLATION AT LYS-2.
RC TISSUE=Venom;
RA Guedes H.L.M., Correa-Neto C., De Simone S.G.;
RL Submitted (NOV-2005) to UniProtKB.
CC -!- FUNCTION: Toxin. Induces vasodilation in mice and rabbits.
CC {ECO:0000269|Ref.1}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.1}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|Ref.1}.
CC -!- PTM: Occurs in two forms. In form 1384.7 Da venom vasodilator peptide
CC Lys-2 is methylated. In form 1370.6 Da venom vasodilator peptide Lys-2
CC is not methylated. {ECO:0000269|Ref.1}.
CC -!- MASS SPECTROMETRY: Mass=1370.6719; Mass_error=1; Method=MALDI;
CC Note=Form 1370.6 Da venom vasodilator peptide.;
CC Evidence={ECO:0000269|Ref.1};
CC -!- MASS SPECTROMETRY: Mass=1384.72; Mass_error=1; Method=MALDI; Note=Form
CC 1384.7 Da venom vasodilator peptide.; Evidence={ECO:0000269|Ref.1};
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DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Methylation; Secreted; Toxin.
FT PEPTIDE 1..12
FT /note="1370.6 Da venom vasodilator peptide"
FT /id="PRO_0000045325"
FT MOD_RES 2
FT /note="N6-methyllysine; partial"
FT /evidence="ECO:0000269|Ref.1"
SQ SEQUENCE 12 AA; 1371 MW; 31EAB6A567736417 CRC64;
PKVSPRWPPI PP