VW5B1_MOUSE
ID VW5B1_MOUSE Reviewed; 1215 AA.
AC A9Z1V5; Q6PFX4; Q9CUE8;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=von Willebrand factor A domain-containing protein 5B1;
DE Flags: Precursor;
GN Name=Vwa5b1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1209.
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR EMBL; BC057376; AAH57376.1; -; mRNA.
DR EMBL; BC132477; AAI32478.2; -; mRNA.
DR EMBL; AK016425; BAB30227.1; -; mRNA.
DR CCDS; CCDS51336.1; -.
DR RefSeq; NP_083677.1; NM_029401.1.
DR RefSeq; XP_006539306.1; XM_006539243.3.
DR RefSeq; XP_006539307.1; XM_006539244.2.
DR RefSeq; XP_011248651.1; XM_011250349.1.
DR RefSeq; XP_017175922.1; XM_017320433.1.
DR AlphaFoldDB; A9Z1V5; -.
DR BioGRID; 217690; 1.
DR STRING; 10090.ENSMUSP00000030533; -.
DR GlyGen; A9Z1V5; 1 site.
DR iPTMnet; A9Z1V5; -.
DR PhosphoSitePlus; A9Z1V5; -.
DR PaxDb; A9Z1V5; -.
DR PRIDE; A9Z1V5; -.
DR ProteomicsDB; 299958; -.
DR Antibodypedia; 29787; 14 antibodies from 8 providers.
DR DNASU; 75718; -.
DR Ensembl; ENSMUST00000030533; ENSMUSP00000030533; ENSMUSG00000028753.
DR GeneID; 75718; -.
DR KEGG; mmu:75718; -.
DR UCSC; uc008vla.2; mouse.
DR CTD; 127731; -.
DR MGI; MGI:1922968; Vwa5b1.
DR VEuPathDB; HostDB:ENSMUSG00000028753; -.
DR eggNOG; ENOG502QVJP; Eukaryota.
DR GeneTree; ENSGT00940000158938; -.
DR HOGENOM; CLU_005270_0_0_1; -.
DR InParanoid; A9Z1V5; -.
DR OMA; PPMETVH; -.
DR OrthoDB; 955432at2759; -.
DR PhylomeDB; A9Z1V5; -.
DR TreeFam; TF329720; -.
DR BioGRID-ORCS; 75718; 2 hits in 71 CRISPR screens.
DR PRO; PR:A9Z1V5; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; A9Z1V5; protein.
DR Bgee; ENSMUSG00000028753; Expressed in hypothalamus and 27 other tissues.
DR ExpressionAtlas; A9Z1V5; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR Gene3D; 3.40.50.410; -; 1.
DR InterPro; IPR013694; VIT.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR Pfam; PF13757; VIT_2; 1.
DR Pfam; PF13768; VWA_3; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; SSF53300; 1.
DR PROSITE; PS51468; VIT; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Phosphoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..1215
FT /note="von Willebrand factor A domain-containing protein
FT 5B1"
FT /id="PRO_0000326174"
FT DOMAIN 19..141
FT /note="VIT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00801"
FT DOMAIN 353..532
FT /note="VWFA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
FT REGION 595..674
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 934..953
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 964..999
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1100..1121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 595..627
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 643..668
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 879
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:Q5TIE3"
FT CARBOHYD 132
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 538
FT /note="F -> L (in Ref. 2; BAB30227)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1215 AA; 133972 MW; 60DA7146EB08FDD6 CRC64;
MPGLLNCLTG AALPLMESDV TSYVSGYALG LTASLTYGNL EAQPFQGLFV YPIDEYSTVV
GFEAVIADRV VTIQLRDKAK LDRSHLDIQP ATVTGNFPEE ESPIAPGKVT LDEDLERVLF
VVNLGTIAPM ENVTVFISTS SELPTLPSGA VRVLLPAICA PTVPPSCTHR FGSSSPQPQG
KDPHCFGTQT KDSYNRLCLA TLLDTKVTNP MEYEFKFQLE IRGPCLLAGV ESPTHEIRAD
AAPSAHSAKS IIITLAKKHT FDRPVEILLH PSEPHMPHVL VEKGDMTLGE YDQHLKGKAD
FIRGTKKDNS AERKTEVIRK RLHKDIPHHS VIMLNFCPDL QSVQPNPRKA HGEFIFLIDR
SNSMSKTNIQ CIKEAMLVAL KSLMPACFFN IIGFGSTFKA VFASSRIYNE ENLTMACDCI
QRMQADMGGT NMLSPLKWVL RQPLRRGHPR LLFLITDGSV NNTGKVLELV RNHASSTRCY
SFGIGPTVCY RLVKGLASVS KGSAEFLMEG ERLQPKMVKS LKKAMAPVLS DVTVEWVFPE
TTEALISPVS TSSLFPGERL MGYGIVCDAS LYISNSRSDK RRKYGMLHTQ ESSSSVFYPS
QDEGLSPGSG NCAKNVNQGQ TKDAHPCNGD SPTHHGLDVS RRRRAYSTNQ ISSHKTCPRA
TTASDPTGTA RRYPLRKAKV QDLASESDWE SQKWQTDLQT LLNEGHNLSQ GPKLHGPGAR
RPSLLPQGCQ LMRFFDQKPQ AWGPVRELDC GASRTSAPNS QSSEDLAIEP AHCPSTFERE
TSLDLEPMAE SEEQANPCRT ATPSPVVGKA LVKGLCANQR MQWEVSFELE PPALKRGDTQ
NADMWSETFH HLAARAIIRE FEHLAEREDE IELGSNRRYQ VNAVHTSKAC SVISKYTAFV
PVDINKRQYL PTVVKYPNSG AMLSFRNLTR QWGGSSAGLG RPQSMLREHS SAAGDSKFQT
LALQDSPTST FNKTPSPGHE KQTTAEGPPQ NLSASAPSSM KATETLFGSK LNLNKSRLLT
RATKGFLSKS LPKASEATPG SQSSDYIPLV SLQLASGAFL LNEAFCTTIQ IPMEKLKWTS
PFSCLRMSLV TRRQDLKTQS PQDCTSLSSS PPSCDGISLK SEESSDQESN AMLEHMGKLW
ATVVALAWLE HSSANYIIEW ELVAAKASSW VEKQKVPEGR TLSTLKNTAR QLFVLLRHWD
EKLEFNMLCY NPNYV
