ID   VWA1_RAT                Reviewed;         415 AA.
AC   Q642A6;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=von Willebrand factor A domain-containing protein 1;
DE   Flags: Precursor;
GN   Name=Vwa1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Promotes matrix assembly (By similarity). Involved in the
CC       organization of skeletal muscles and in the formation of neuromuscular
CC       junctions (By similarity). {ECO:0000250|UniProtKB:E7FF10,
CC       ECO:0000250|UniProtKB:Q8R2Z5}.
CC   -!- SUBUNIT: Homodimer or homomultimer; disulfide-linked. Interacts with
CC       HSPG2. {ECO:0000250|UniProtKB:Q8R2Z5}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix, basement membrane {ECO:0000250|UniProtKB:Q8R2Z5}.
CC   -!- PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q8R2Z5}.
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DR   EMBL; BC081983; AAH81983.1; -; mRNA.
DR   RefSeq; NP_001013960.1; NM_001013938.1.
DR   AlphaFoldDB; Q642A6; -.
DR   SMR; Q642A6; -.
DR   STRING; 10116.ENSRNOP00000024897; -.
DR   GlyGen; Q642A6; 1 site.
DR   PaxDb; Q642A6; -.
DR   PRIDE; Q642A6; -.
DR   Ensembl; ENSRNOT00000024897; ENSRNOP00000024897; ENSRNOG00000018338.
DR   GeneID; 298683; -.
DR   KEGG; rno:298683; -.
DR   CTD; 64856; -.
DR   RGD; 1311476; Vwa1.
DR   eggNOG; KOG1217; Eukaryota.
DR   eggNOG; KOG3544; Eukaryota.
DR   GeneTree; ENSGT00940000160734; -.
DR   HOGENOM; CLU_042926_0_0_1; -.
DR   InParanoid; Q642A6; -.
DR   OMA; PEGVLNC; -.
DR   OrthoDB; 67372at2759; -.
DR   PhylomeDB; Q642A6; -.
DR   PRO; PR:Q642A6; -.
DR   Proteomes; UP000002494; Chromosome 5.
DR   Bgee; ENSRNOG00000018338; Expressed in jejunum and 19 other tissues.
DR   Genevisible; Q642A6; RN.
DR   GO; GO:0005604; C:basement membrane; ISO:RGD.
DR   GO; GO:0031012; C:extracellular matrix; ISO:RGD.
DR   GO; GO:0005576; C:extracellular region; ISO:RGD.
DR   GO; GO:0005614; C:interstitial matrix; ISO:RGD.
DR   GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR   GO; GO:0048266; P:behavioral response to pain; ISO:RGD.
DR   GO; GO:0030198; P:extracellular matrix organization; ISO:RGD.
DR   CDD; cd00063; FN3; 2.
DR   Gene3D; 2.60.40.10; -; 2.
DR   Gene3D; 3.40.50.410; -; 1.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR030758; Vwa1.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR24020:SF51; PTHR24020:SF51; 1.
DR   Pfam; PF00041; fn3; 2.
DR   Pfam; PF00092; VWA; 1.
DR   SMART; SM00060; FN3; 2.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF49265; SSF49265; 1.
DR   SUPFAM; SSF53300; SSF53300; 1.
DR   PROSITE; PS50853; FN3; 2.
DR   PROSITE; PS50234; VWFA; 1.
PE   2: Evidence at transcript level;
KW   Basement membrane; Disulfide bond; Extracellular matrix; Glycoprotein;
KW   Phosphoprotein; Reference proteome; Repeat; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..415
FT                   /note="von Willebrand factor A domain-containing protein 1"
FT                   /id="PRO_0000307158"
FT   DOMAIN          34..213
FT                   /note="VWFA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
FT   DOMAIN          214..305
FT                   /note="Fibronectin type-III 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT   DOMAIN          307..405
FT                   /note="Fibronectin type-III 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT   MOD_RES         74
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6PCB0"
FT   MOD_RES         80
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6PCB0"
FT   MOD_RES         93
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6PCB0"
FT   CARBOHYD        264
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        369..393
FT                   /evidence="ECO:0000250|UniProtKB:Q8R2Z5"
SQ   SEQUENCE   415 AA;  44832 MW;  B3A0A0268DB06D4E CRC64;
     MLFWTVLSMA LSLRLALAQS GIERGPTASA PQGDLLFLLD SSASVSHYEF SRVREFVGQL
     VATMPFGPGA LRASLVHVGS RPHTEFTFDQ YSSGQAIQDA VRVAPQRMGD TNTGLALAYA
     KEQLFAEEAG ARLGVPKVLV WVTDGASSDS VGPPMQELKD LGVTIFIVST GRGNLLELLA
     AASAPAEKHL HFVDVDDLPI IARELRGAII DAMQPHQLHA SEILSNGFRL SWPPLLTADS
     GYYVLELVPS GKLAATRRQQ LPGNATSWTW TDLNPDTDYE VSLLPESNVR LLRPQHLRVR
     TLQEEAGPER IVISHTRPRS LRVSWAPALG PDSTLGYLVQ LGPLQGGSLE HVEVPAGQNS
     TTIQGLTPCT TYLVTVTAAF RSGRQRALSA KACTASGERI RVPQAMRPEA GLREP