ID   VWA2_XENLA              Reviewed;         790 AA.
AC   Q6DCQ6;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=von Willebrand factor A domain-containing protein 2;
DE   AltName: Full=A domain-containing protein similar to matrilin and collagen;
DE            Short=AMACO;
DE   Flags: Precursor;
GN   Name=vwa2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Forms monomers and multimers. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
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DR   EMBL; BC077945; AAH77945.1; -; mRNA.
DR   RefSeq; NP_001087052.1; NM_001093583.1.
DR   AlphaFoldDB; Q6DCQ6; -.
DR   SMR; Q6DCQ6; -.
DR   DNASU; 446887; -.
DR   GeneID; 446887; -.
DR   KEGG; xla:446887; -.
DR   CTD; 446887; -.
DR   Xenbase; XB-GENE-6255089; vwa2.S.
DR   OrthoDB; 350336at2759; -.
DR   Proteomes; UP000186698; Chromosome 7S.
DR   Bgee; 446887; Expressed in internal ear and 10 other tissues.
DR   GO; GO:0005604; C:basement membrane; IEA:InterPro.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   Gene3D; 3.40.50.410; -; 3.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR030755; VWA2.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR24020:SF37; PTHR24020:SF37; 1.
DR   Pfam; PF00008; EGF; 2.
DR   Pfam; PF00092; VWA; 3.
DR   SMART; SM00181; EGF; 2.
DR   SMART; SM00179; EGF_CA; 2.
DR   SMART; SM00327; VWA; 3.
DR   SUPFAM; SSF53300; SSF53300; 3.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS50026; EGF_3; 2.
DR   PROSITE; PS50234; VWFA; 3.
PE   2: Evidence at transcript level;
KW   Disulfide bond; EGF-like domain; Reference proteome; Repeat; Secreted;
KW   Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..790
FT                   /note="von Willebrand factor A domain-containing protein 2"
FT                   /id="PRO_0000307363"
FT   DOMAIN          50..221
FT                   /note="VWFA 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
FT   DOMAIN          295..332
FT                   /note="EGF-like 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          342..518
FT                   /note="VWFA 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
FT   DOMAIN          532..702
FT                   /note="VWFA 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
FT   DOMAIN          713..748
FT                   /note="EGF-like 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   REGION          758..790
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        764..790
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        298..309
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        303..319
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        321..331
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        717..728
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        722..737
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        739..747
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
SQ   SEQUENCE   790 AA;  86480 MW;  43461DA436955A7F CRC64;
     MRLPWVNGIL AFLSSQVLQC LCVQELHVNA ETANKISAAG RRMRCSSPLD ILILLDGSNS
     IGRGSFERSK HFASKLCDAL DIGSDLIRVG AMQYSGAPQV EFRLDSSFSK AAIKEKIKSI
     VFKGGPTETG LALKYIVWKG FPGGRPASVP KILIIVSDGK SQGNIKLPAA QIKGEDIEVF
     TVGVKFPRWE ELHALSSEPQ EAHVLFAEHV DDAVNGLATS LTNSSLCSSV PHGCSVQSFP
     CTRKTLETVK ELTGNYMCWK GSARPGTVFP GHCPFYSWRR FYNKHQAQCH RTVCPDPCDS
     QPCKNGGTCI AEGQDKYHCV CPAGFGGDTE CAPQLSLECN IDLLFLVDSS DTTSLEAFMQ
     HKSFLKRFIQ ASLSDESPLN VGVAQYSNEV QMVVKIGEYQ SMAELLKHID NMRFMGGGLF
     TGKALRYVTQ YGFKSTPVFS DVRDDLPRLV VLLTGSKSQD SVTGPATYAR DQEVFLIGVT
     SDSNKGEMAE IVGNPLNLVT YSNPQQLFNQ LPQLQKRICS IDVQGCQAQP LDLAFVLDAS
     TAVGQEKFNR LKNFVTMVSL QFDINRDVTQ IGLVTYSSRP ETVFGLDTHD SGSSLLQGIG
     RASYMGGSAS TGSALLRVYN DVMTVQKGAR PGVNKAVVVI TDGRGAEDAA VPAQKLRDNG
     IMVYVIGIGN IQRNSLLRLA GSEKFLISVP SYESLGHYED SVVQRVCEDA KSPVNLCKPN
     PCMNDGVCIL RQGSYRCDCR GWDGPHCETR ILRGDSHWPQ GLHSRSRQQR HSRKRRLKSV
     SGSRSSRKKP