VWA3A_MOUSE
ID VWA3A_MOUSE Reviewed; 1148 AA.
AC Q3UVV9; Q8C349;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=von Willebrand factor A domain-containing protein 3A;
GN Name=Vwa3a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Diencephalon, and Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC39770.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC39770.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK086942; BAC39770.1; ALT_FRAME; mRNA.
DR EMBL; AK136898; BAE23160.1; -; mRNA.
DR CCDS; CCDS40112.1; -.
DR RefSeq; NP_808365.2; NM_177697.3.
DR RefSeq; XP_006507758.1; XM_006507695.3.
DR RefSeq; XP_006507759.1; XM_006507696.3.
DR AlphaFoldDB; Q3UVV9; -.
DR SMR; Q3UVV9; -.
DR STRING; 10090.ENSMUSP00000033180; -.
DR iPTMnet; Q3UVV9; -.
DR PhosphoSitePlus; Q3UVV9; -.
DR MaxQB; Q3UVV9; -.
DR PaxDb; Q3UVV9; -.
DR PeptideAtlas; Q3UVV9; -.
DR PRIDE; Q3UVV9; -.
DR ProteomicsDB; 297620; -.
DR Antibodypedia; 51004; 33 antibodies from 10 providers.
DR DNASU; 233813; -.
DR Ensembl; ENSMUST00000033180; ENSMUSP00000033180; ENSMUSG00000030889.
DR Ensembl; ENSMUST00000166668; ENSMUSP00000129136; ENSMUSG00000030889.
DR Ensembl; ENSMUST00000167213; ENSMUSP00000133029; ENSMUSG00000030889.
DR GeneID; 233813; -.
DR KEGG; mmu:233813; -.
DR UCSC; uc009jna.1; mouse.
DR CTD; 146177; -.
DR MGI; MGI:3041229; Vwa3a.
DR VEuPathDB; HostDB:ENSMUSG00000030889; -.
DR eggNOG; ENOG502QTDG; Eukaryota.
DR GeneTree; ENSGT00940000159290; -.
DR HOGENOM; CLU_008839_0_0_1; -.
DR InParanoid; Q3UVV9; -.
DR OMA; ISRCMGP; -.
DR OrthoDB; 580729at2759; -.
DR PhylomeDB; Q3UVV9; -.
DR TreeFam; TF328978; -.
DR BioGRID-ORCS; 233813; 4 hits in 73 CRISPR screens.
DR ChiTaRS; Vwa3a; mouse.
DR PRO; PR:Q3UVV9; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q3UVV9; protein.
DR Bgee; ENSMUSG00000030889; Expressed in seminiferous tubule of testis and 52 other tissues.
DR ExpressionAtlas; Q3UVV9; baseline and differential.
DR Gene3D; 3.40.50.410; -; 2.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR Pfam; PF13768; VWA_3; 3.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; SSF53300; 2.
DR PROSITE; PS50234; VWFA; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat.
FT CHAIN 1..1148
FT /note="von Willebrand factor A domain-containing protein
FT 3A"
FT /id="PRO_0000324625"
FT DOMAIN 484..681
FT /note="VWFA 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
FT DOMAIN 923..1094
FT /note="VWFA 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 701..734
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 701..717
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 1132
FT /note="R -> T (in Ref. 1; BAC39770)"
FT /evidence="ECO:0000305"
FT CONFLICT 1139
FT /note="N -> T (in Ref. 1; BAC39770)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1148 AA; 130106 MW; 10C57533AD0A4D8C CRC64;
MKKCRWSMDR NTDRDPQKQE NKKTMNDLAQ TSQDGLLVTH VNQTQDLLQL QGRETQTSAL
EDSEDWLAMH SLKFEKLTLA DLISQGTVEL EDCNNAVPKV HFTTQTIHHF KSRLSDTIEL
YQQRMRWLTE NSKKAFGLIK GSRVGLLIDS SQVSSGSQTK EFQNDLTGLI DEQLSLKEKL
YVLSFGVTIN PLWPDPMEVS TSTLQELKLW VKTLQPEGSS NLLQALKKVF AHKELNSLVI
ILRSCPDQPS EFLSDFIQQS TLGRSVFIHV TTYKCDDHVP SAVLKNLTDA LGGYYHCYSP
ESELYTSRDV VELQVETHKA QGLLSQVQAL CHNNPCEELS CMIKEISIEI AKGPFTSLLP
KPPKHEAPLT IKFPDLDKTS AEWLKINGLK AKKLSLYQVL APNAFNPVEE FVPILQKTVA
ATIHEKAMVQ FEWHDGTVKN IHVDPPVLFE YQKQLGKAVQ IYEHRLQWLS LTSRRIWGTV
CQRRVVILLD VSVTNSMYII HIQHSLRLLL EEQLSNKDYF NIIAFGSTIE SWRPEMVAVS
HDNLQRAWRW ALGLQCQGSR NVLGALRKAI EVDFKDKNKH ESQGIYLFTG GIPDQDVHIL
SAYVAEAYGG CDLQLNVCLF YVGEPQMDTT PPACYASRTD TATAYKEITQ AARGRFHWFG
ETGIYESDDI NAIVSEIEKA LNYSQKCAFL VASLKNHSEK ELQSGALEKD KPRTLKQSQP
KKHYPPKPTA PSVARMSIKD GLDGETSSRL KALKCHPVNA AAQPEKEGTV EQRMKTKPRT
RPKLFLFYTE AGNSVGSVYK RYTQGKSIRR INSSIQLPRK DTVCSSQEWT ATCRLKRLKL
ELSKCLGPNC RYQKSVRGPA LAEHCTLFPS IEINGVVRHI QWTLWEMETY ITCMEKVTRC
YVQRLHWLLS GSRRLFGTIL ERNVCILLDT SGSMGPHLQW IKTELVLLIW EQLRKHCARF
NLLSFAEDLQ LWQDTLVEST EAACHKAMQW VAHLQAQGST SVLAALTKAF SFQDVQGLYL
LTDGKPDTSC SLILNTVQSF QKERGVKVHT ISLTSADRTA TEFLRELASL SGGRYHCPVS
DKALSGIQGL LTRGFIKERD PKLPLFEGDD LRLLAEEFTR ARNLLKQAQV FRSQLLKKNN
MKSKVTSC
